Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau.P301S mouse model of Alzheimer’s disease and frontotemporal dementia

Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau.P301S mouse model of Alzheimer’s disease and frontotemporal dementia

Abstract Background Truncated mis-disordered tau protein plays an important role in the pathogenesis of Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Tau294–305, an epitope in the truncated tau, is essential for pathological tau-tau interaction and aggregation. A tau294–305-targeted ap...

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Bibliographic Details
Main Authors: Mei Ji, Xi-xiu Xie, Dong-qun Liu, Xiao-lin Yu, Yue Zhang, Ling-Xiao Zhang, Shao-wei Wang, Ya-ru Huang, Rui-tian Liu
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Frontotemporal dementia
Hepatitis B core protein
Truncated tau
Neurofibrillary tangles
Virus-like particles (VLPs)
Online Access:http://link.springer.com/article/10.1186/s13195-018-0378-7

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