Expression characteristics and their functional role of IGFBP gene family in pan-cancer
Abstract Background Insulin-like growth factor binding proteins (IGFBPs) are critical regulators of the biological activities of insulin-like growth factors. The IGFBP family plays diverse roles in different types of cancer, which we still lack comprehensive and pleiotropic understandings so far. Me...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-023-10832-3 |
| _version_ | 1797836453618647040 |
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| author | Yingnan Liu Shixuan Shen Ziwei Yan Lirong Yan Hanxi Ding Ang Wang Qian Xu Liping Sun Yuan Yuan |
| author_facet | Yingnan Liu Shixuan Shen Ziwei Yan Lirong Yan Hanxi Ding Ang Wang Qian Xu Liping Sun Yuan Yuan |
| author_sort | Yingnan Liu |
| collection | DOAJ |
| description | Abstract Background Insulin-like growth factor binding proteins (IGFBPs) are critical regulators of the biological activities of insulin-like growth factors. The IGFBP family plays diverse roles in different types of cancer, which we still lack comprehensive and pleiotropic understandings so far. Methods Multi-source and multi-dimensional data, extracted from The Cancer Genome Atlas (TCGA), Oncomine, Cancer Cell Line Encyclopedia (CCLE), and the Human Protein Atlas (HPA) was used for bioinformatics analysis by R language. Immunohistochemistry and qRT-PCR were performed to validate the results of the database analysis results. Bibliometrics and literature review were used for summarizing the research progress of IGFBPs in the field of tumor. Results The members of IGFBP gene family are differentially expressed in various cancer types. IGFBPs expression can affect prognosis of different cancers. The expression of IGFBPs expression is associated with multiple signal transduction pathways. The expression of IGFBPs is significantly correlated with tumor mutational burden, microsatellite instability, tumor stemness and tumor immune microenvironment. The qRT-PCR experiments verified the lower expression of IGFBP2 and IGFBP6 in gastric cancer and the lower expression of IGFBP6 in colorectal cancer. Immunohistochemistry validated a marked downregulation of IGFBP2 protein in gastric cancer tissues. The keywords co-occurrence analysis of IGFBP related publications in cancer showed relative research have been more concentrating on the potential of IGFBPs as tumor diagnostic and prognostic markers and developing cancer therapies. Conclusions These findings provide frontier trend of IGFBPs related research and new clues for identifying novel therapeutic targets for various cancers. |
| first_indexed | 2024-04-09T15:09:08Z |
| format | Article |
| id | doaj.art-f50964af5e8c420d99efed4a666a2f51 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-09T15:09:08Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-f50964af5e8c420d99efed4a666a2f512023-04-30T11:18:54ZengBMCBMC Cancer1471-24072023-04-0123113110.1186/s12885-023-10832-3Expression characteristics and their functional role of IGFBP gene family in pan-cancerYingnan Liu0Shixuan Shen1Ziwei Yan2Lirong Yan3Hanxi Ding4Ang Wang5Qian Xu6Liping Sun7Yuan Yuan8Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical UniversityTumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical UniversityTumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical UniversityTumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical UniversityTumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical UniversityTumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical UniversityTumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical UniversityTumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical UniversityTumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical UniversityAbstract Background Insulin-like growth factor binding proteins (IGFBPs) are critical regulators of the biological activities of insulin-like growth factors. The IGFBP family plays diverse roles in different types of cancer, which we still lack comprehensive and pleiotropic understandings so far. Methods Multi-source and multi-dimensional data, extracted from The Cancer Genome Atlas (TCGA), Oncomine, Cancer Cell Line Encyclopedia (CCLE), and the Human Protein Atlas (HPA) was used for bioinformatics analysis by R language. Immunohistochemistry and qRT-PCR were performed to validate the results of the database analysis results. Bibliometrics and literature review were used for summarizing the research progress of IGFBPs in the field of tumor. Results The members of IGFBP gene family are differentially expressed in various cancer types. IGFBPs expression can affect prognosis of different cancers. The expression of IGFBPs expression is associated with multiple signal transduction pathways. The expression of IGFBPs is significantly correlated with tumor mutational burden, microsatellite instability, tumor stemness and tumor immune microenvironment. The qRT-PCR experiments verified the lower expression of IGFBP2 and IGFBP6 in gastric cancer and the lower expression of IGFBP6 in colorectal cancer. Immunohistochemistry validated a marked downregulation of IGFBP2 protein in gastric cancer tissues. The keywords co-occurrence analysis of IGFBP related publications in cancer showed relative research have been more concentrating on the potential of IGFBPs as tumor diagnostic and prognostic markers and developing cancer therapies. Conclusions These findings provide frontier trend of IGFBPs related research and new clues for identifying novel therapeutic targets for various cancers.https://doi.org/10.1186/s12885-023-10832-3IGFBPPan-cancerExpressionPrognosisCancer-related pathwayTumor immune microenvironment |
| spellingShingle | Yingnan Liu Shixuan Shen Ziwei Yan Lirong Yan Hanxi Ding Ang Wang Qian Xu Liping Sun Yuan Yuan Expression characteristics and their functional role of IGFBP gene family in pan-cancer BMC Cancer IGFBP Pan-cancer Expression Prognosis Cancer-related pathway Tumor immune microenvironment |
| title | Expression characteristics and their functional role of IGFBP gene family in pan-cancer |
| title_full | Expression characteristics and their functional role of IGFBP gene family in pan-cancer |
| title_fullStr | Expression characteristics and their functional role of IGFBP gene family in pan-cancer |
| title_full_unstemmed | Expression characteristics and their functional role of IGFBP gene family in pan-cancer |
| title_short | Expression characteristics and their functional role of IGFBP gene family in pan-cancer |
| title_sort | expression characteristics and their functional role of igfbp gene family in pan cancer |
| topic | IGFBP Pan-cancer Expression Prognosis Cancer-related pathway Tumor immune microenvironment |
| url | https://doi.org/10.1186/s12885-023-10832-3 |
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