Impact of Infection Patterns on the Outcomes of Patients with Hematological Malignancies in Southwest China: A 10-Year Retrospective Case-Control Study
Yali Yang,1,* Junjie Li,2,* Shifeng Huang,1 Junnan Li,3 Shuangshuang Yang1 1Department of Laboratory Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Key Laboratory of Laboratory Medical Diagnostics, Ministry of Educatio...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2023-06-01
|
| Series: | Infection and Drug Resistance |
| Subjects: | |
| Online Access: | https://www.dovepress.com/impact-of-infection-patterns-on-the-outcomes-of-patients-with-hematolo-peer-reviewed-fulltext-article-IDR |
| _version_ | 1797789467300331520 |
|---|---|
| author | Yang Y Li J Huang S Li J Yang S |
| author_facet | Yang Y Li J Huang S Li J Yang S |
| author_sort | Yang Y |
| collection | DOAJ |
| description | Yali Yang,1,* Junjie Li,2,* Shifeng Huang,1 Junnan Li,3 Shuangshuang Yang1 1Department of Laboratory Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Key Laboratory of Laboratory Medical Diagnostics, Ministry of Education, Department of Laboratory Medicine, Chongqing Medical University, Chongqing, People’s Republic of China; 3Department of Hematology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shuangshuang Yang, Department of Laboratory Medicine, the First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, 400016, People’s Republic of China, Tel +86-23-8901-1841, Fax +86-23-8901-2513, Email yangss2019@hospital.cqmu.edu.cnBackground: This study aimed to assess the effect of infection patterns on the outcomes of patients with hematological malignancies (HM) and to identify the determinants of in-hospital mortality.Methods: A case-control study was retrospectively conducted in a tertiary teaching hospital in Chongqing, Southwest China from 2011 to 2020. Clinical characteristics, microbial findings, and outcomes of HM patients with infections were retrieved from the hospital information system. Chi-square or Fisher’s exact test was adopted to test the significance of mortality rate. Kaplan-Meier survival analysis and Log rank test were applied to evaluate and compare the 30-day survival rates of those groups. Binary logistic regression, Cox proportional hazards regression, and receiver operating characteristic curves were used to investigate the determinants of in-hospital mortality.Results: Of 1,570 enrolled participants, 43.63% suffered from acute myeloid leukemia, 69.62% received chemotherapy, and 25.73% had hematopoietic stem cell transplantation (HSCT). Microbial infection was documented in 83.38% of participants. Co-infection and septic shock were reported in 32.87% and 5.67% of participants, respectively. Patients with septic shock suffered a significantly lower 30-day survival rate, while those with distinct types of pathogens or co-infections had a comparable 30-day survival rate. The all-cause in-hospital mortality was 7.01% and higher mortality rate was observed in patients with allo-HSCT (7.20%), co-infection (9.88%), and septic shock (33.71%). Cox proportional hazards regression illustrated that elderly age, septic shock, and elevated procalcitonin (PCT) were independent predictors of in-hospital mortality. A PCT cut-off value of 0.24 ng/mL predicted in-hospital mortality with a sensitivity of 77.45% and a specificity of 59.80% (95% CI = 0.684– 0.779, P< 0.0001).Conclusion: Distinct infectious patterns of HM inpatients were previously unreported in Southwest China. It was the severity of infection, not co-infection, source of infection, or type of causative pathogen that positively related to poor outcome. PCT guided early recognition and treatment of septic shock were advocated.Keywords: early survival, hematological malignancies, in-hospital mortality, microbial co-infection, septic shock, determinants |
| first_indexed | 2024-03-13T01:51:04Z |
| format | Article |
| id | doaj.art-f50a079cea1a4cbdb3b7a401eca602e6 |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-03-13T01:51:04Z |
| publishDate | 2023-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-f50a079cea1a4cbdb3b7a401eca602e62023-07-02T19:49:16ZengDove Medical PressInfection and Drug Resistance1178-69732023-06-01Volume 163659366984313Impact of Infection Patterns on the Outcomes of Patients with Hematological Malignancies in Southwest China: A 10-Year Retrospective Case-Control StudyYang YLi JHuang SLi JYang SYali Yang,1,* Junjie Li,2,* Shifeng Huang,1 Junnan Li,3 Shuangshuang Yang1 1Department of Laboratory Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Key Laboratory of Laboratory Medical Diagnostics, Ministry of Education, Department of Laboratory Medicine, Chongqing Medical University, Chongqing, People’s Republic of China; 3Department of Hematology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shuangshuang Yang, Department of Laboratory Medicine, the First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, 400016, People’s Republic of China, Tel +86-23-8901-1841, Fax +86-23-8901-2513, Email yangss2019@hospital.cqmu.edu.cnBackground: This study aimed to assess the effect of infection patterns on the outcomes of patients with hematological malignancies (HM) and to identify the determinants of in-hospital mortality.Methods: A case-control study was retrospectively conducted in a tertiary teaching hospital in Chongqing, Southwest China from 2011 to 2020. Clinical characteristics, microbial findings, and outcomes of HM patients with infections were retrieved from the hospital information system. Chi-square or Fisher’s exact test was adopted to test the significance of mortality rate. Kaplan-Meier survival analysis and Log rank test were applied to evaluate and compare the 30-day survival rates of those groups. Binary logistic regression, Cox proportional hazards regression, and receiver operating characteristic curves were used to investigate the determinants of in-hospital mortality.Results: Of 1,570 enrolled participants, 43.63% suffered from acute myeloid leukemia, 69.62% received chemotherapy, and 25.73% had hematopoietic stem cell transplantation (HSCT). Microbial infection was documented in 83.38% of participants. Co-infection and septic shock were reported in 32.87% and 5.67% of participants, respectively. Patients with septic shock suffered a significantly lower 30-day survival rate, while those with distinct types of pathogens or co-infections had a comparable 30-day survival rate. The all-cause in-hospital mortality was 7.01% and higher mortality rate was observed in patients with allo-HSCT (7.20%), co-infection (9.88%), and septic shock (33.71%). Cox proportional hazards regression illustrated that elderly age, septic shock, and elevated procalcitonin (PCT) were independent predictors of in-hospital mortality. A PCT cut-off value of 0.24 ng/mL predicted in-hospital mortality with a sensitivity of 77.45% and a specificity of 59.80% (95% CI = 0.684– 0.779, P< 0.0001).Conclusion: Distinct infectious patterns of HM inpatients were previously unreported in Southwest China. It was the severity of infection, not co-infection, source of infection, or type of causative pathogen that positively related to poor outcome. PCT guided early recognition and treatment of septic shock were advocated.Keywords: early survival, hematological malignancies, in-hospital mortality, microbial co-infection, septic shock, determinantshttps://www.dovepress.com/impact-of-infection-patterns-on-the-outcomes-of-patients-with-hematolo-peer-reviewed-fulltext-article-IDRearly survivalhematological malignanciesin-hospital mortalitymicrobial co-infectionsepsis shockdeterminants. |
| spellingShingle | Yang Y Li J Huang S Li J Yang S Impact of Infection Patterns on the Outcomes of Patients with Hematological Malignancies in Southwest China: A 10-Year Retrospective Case-Control Study Infection and Drug Resistance early survival hematological malignancies in-hospital mortality microbial co-infection sepsis shock determinants. |
| title | Impact of Infection Patterns on the Outcomes of Patients with Hematological Malignancies in Southwest China: A 10-Year Retrospective Case-Control Study |
| title_full | Impact of Infection Patterns on the Outcomes of Patients with Hematological Malignancies in Southwest China: A 10-Year Retrospective Case-Control Study |
| title_fullStr | Impact of Infection Patterns on the Outcomes of Patients with Hematological Malignancies in Southwest China: A 10-Year Retrospective Case-Control Study |
| title_full_unstemmed | Impact of Infection Patterns on the Outcomes of Patients with Hematological Malignancies in Southwest China: A 10-Year Retrospective Case-Control Study |
| title_short | Impact of Infection Patterns on the Outcomes of Patients with Hematological Malignancies in Southwest China: A 10-Year Retrospective Case-Control Study |
| title_sort | impact of infection patterns on the outcomes of patients with hematological malignancies in southwest china a 10 year retrospective case control study |
| topic | early survival hematological malignancies in-hospital mortality microbial co-infection sepsis shock determinants. |
| url | https://www.dovepress.com/impact-of-infection-patterns-on-the-outcomes-of-patients-with-hematolo-peer-reviewed-fulltext-article-IDR |
| work_keys_str_mv | AT yangy impactofinfectionpatternsontheoutcomesofpatientswithhematologicalmalignanciesinsouthwestchinaa10yearretrospectivecasecontrolstudy AT lij impactofinfectionpatternsontheoutcomesofpatientswithhematologicalmalignanciesinsouthwestchinaa10yearretrospectivecasecontrolstudy AT huangs impactofinfectionpatternsontheoutcomesofpatientswithhematologicalmalignanciesinsouthwestchinaa10yearretrospectivecasecontrolstudy AT lij impactofinfectionpatternsontheoutcomesofpatientswithhematologicalmalignanciesinsouthwestchinaa10yearretrospectivecasecontrolstudy AT yangs impactofinfectionpatternsontheoutcomesofpatientswithhematologicalmalignanciesinsouthwestchinaa10yearretrospectivecasecontrolstudy |