Knockout of AMPKα2 Blocked the Protection of Sestrin2 Overexpression Against Cardiac Hypertrophy Induced by Pressure Overload

Knockout of AMPKα2 Blocked the Protection of Sestrin2 Overexpression Against Cardiac Hypertrophy Induced by Pressure Overload

Objectives: Sestrin2 (Sesn2) has been demonstrated to be a cysteine sulfinyl reductase and protects cells from multiple stress insults, including hypoxia, endoplasmic reticulum stress, and oxidative stress. However, the roles and mechanisms of Sesn2 in pressure overload-induced mouse cardiac hypertr...

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Bibliographic Details
Main Authors: Nan Zhang, Hai-Han Liao, Hong Feng, Shan-Qi Mou, Wen-Jing Li, Xiahenazi Aiyasiding, Zheng Lin, Wen Ding, Zi-Ying Zhou, Han Yan, Si Chen, Qi-Zhu Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Pharmacology
Subjects:
Sestrin2
cardiac hypertrophy
fibrosis
AMPKα
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.716884/full

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