Multiple Sclerosis and Pregnancy; Disease Activity and Disease Progression in Pregnancy and Postpartum Period
INTRODUCTION: In this study, it was aimed to investigate how pregnancy and postpartum processes affect the course of MS disease, the effects of breast feeding on the frequency of attacks, and the fetal development in pregnant patients using MS treatment (disease modifying treatment (DMT) METHODS: Ou...
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| Format: | Article |
| Language: | English |
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Van Yuzuncu Yil University, School of Medicine
2021-07-01
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| Series: | Van Tıp Dergisi |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=vtd&un=VTD-72558 |
| _version_ | 1797430294476750848 |
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| author | Vedat Çilingir |
| author_facet | Vedat Çilingir |
| author_sort | Vedat Çilingir |
| collection | DOAJ |
| description | INTRODUCTION: In this study, it was aimed to investigate how pregnancy and postpartum processes affect the course of MS disease, the effects of breast feeding on the frequency of attacks, and the fetal development in pregnant patients using MS treatment (disease modifying treatment (DMT) METHODS: Our pregnant relapsing remitting MS (RRMS) patients who were followed up in our MS outpatient clinic were included in the study. Our patients were followed up during pregnancy and postpartum 1 year. Annualized relapse rate (ARR) was calculated in the year preceding pregnancy, during pregnancy, and in the first year of postpartum. The duration of DMT use while pregnant, pregnancies resulting in miscarriage, low birth weight babies, preterm babies, and breastfeeding times were recorded and evaluated. RESULTS: The number of pregnancies followed was 102 pregnancies, including 89 deliveries and 13 abortions. Twenty nine patients used DMT in some part of their pregnancy due to unplanned pregnancy. The disability condition evaluated before and 12 months after pregnancy progressed in 12 patients. Interestingly, 70 patients remained stable, while seven patients regressed. No relation was found between the use of DMT during pregnancy and miscarriage, preterm baby, and low birth weight baby. Mothers who were not breastfeeding or breastfeeding for less than 3 months experienced more attacks than mothers who breastfed for 3 months or more. DISCUSSION AND CONCLUSION: Disease activity and disability status during pregnancy and the postpartum period did not change in RRMS patients compared to pre-pregnancy. DMTs used during pregnancy did not affect fetal development and abortion status. |
| first_indexed | 2024-03-09T09:26:34Z |
| format | Article |
| id | doaj.art-f50e8bcdf299486085af19012bc40e1d |
| institution | Directory Open Access Journal |
| issn | 2587-0351 |
| language | English |
| last_indexed | 2024-03-09T09:26:34Z |
| publishDate | 2021-07-01 |
| publisher | Van Yuzuncu Yil University, School of Medicine |
| record_format | Article |
| series | Van Tıp Dergisi |
| spelling | doaj.art-f50e8bcdf299486085af19012bc40e1d2023-12-02T06:03:43ZengVan Yuzuncu Yil University, School of MedicineVan Tıp Dergisi2587-03512021-07-0128345245810.5505/vtd.2021.72558VTD-72558Multiple Sclerosis and Pregnancy; Disease Activity and Disease Progression in Pregnancy and Postpartum PeriodVedat Çilingir0Van Yuzuncu Yil University Medicine Faculty Neurology DepartmentINTRODUCTION: In this study, it was aimed to investigate how pregnancy and postpartum processes affect the course of MS disease, the effects of breast feeding on the frequency of attacks, and the fetal development in pregnant patients using MS treatment (disease modifying treatment (DMT) METHODS: Our pregnant relapsing remitting MS (RRMS) patients who were followed up in our MS outpatient clinic were included in the study. Our patients were followed up during pregnancy and postpartum 1 year. Annualized relapse rate (ARR) was calculated in the year preceding pregnancy, during pregnancy, and in the first year of postpartum. The duration of DMT use while pregnant, pregnancies resulting in miscarriage, low birth weight babies, preterm babies, and breastfeeding times were recorded and evaluated. RESULTS: The number of pregnancies followed was 102 pregnancies, including 89 deliveries and 13 abortions. Twenty nine patients used DMT in some part of their pregnancy due to unplanned pregnancy. The disability condition evaluated before and 12 months after pregnancy progressed in 12 patients. Interestingly, 70 patients remained stable, while seven patients regressed. No relation was found between the use of DMT during pregnancy and miscarriage, preterm baby, and low birth weight baby. Mothers who were not breastfeeding or breastfeeding for less than 3 months experienced more attacks than mothers who breastfed for 3 months or more. DISCUSSION AND CONCLUSION: Disease activity and disability status during pregnancy and the postpartum period did not change in RRMS patients compared to pre-pregnancy. DMTs used during pregnancy did not affect fetal development and abortion status.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=vtd&un=VTD-72558pregnancymultiple sclerosisbreast feedingannualized relapse ratedisease progressionpostpartum period |
| spellingShingle | Vedat Çilingir Multiple Sclerosis and Pregnancy; Disease Activity and Disease Progression in Pregnancy and Postpartum Period Van Tıp Dergisi pregnancy multiple sclerosis breast feeding annualized relapse rate disease progression postpartum period |
| title | Multiple Sclerosis and Pregnancy; Disease Activity and Disease Progression in Pregnancy and Postpartum Period |
| title_full | Multiple Sclerosis and Pregnancy; Disease Activity and Disease Progression in Pregnancy and Postpartum Period |
| title_fullStr | Multiple Sclerosis and Pregnancy; Disease Activity and Disease Progression in Pregnancy and Postpartum Period |
| title_full_unstemmed | Multiple Sclerosis and Pregnancy; Disease Activity and Disease Progression in Pregnancy and Postpartum Period |
| title_short | Multiple Sclerosis and Pregnancy; Disease Activity and Disease Progression in Pregnancy and Postpartum Period |
| title_sort | multiple sclerosis and pregnancy disease activity and disease progression in pregnancy and postpartum period |
| topic | pregnancy multiple sclerosis breast feeding annualized relapse rate disease progression postpartum period |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=vtd&un=VTD-72558 |
| work_keys_str_mv | AT vedatcilingir multiplesclerosisandpregnancydiseaseactivityanddiseaseprogressioninpregnancyandpostpartumperiod |