Bifurcation Configuration Is an Independent Risk Factor for Aneurysm Rupture Irrespective of Location
Background: Bifurcation and sidewall aneurysms have different rupture risks, but whether this difference comes from the location of the aneurysm is not clear. The objective of this study is to illustrate the rationality of ranking bifurcation configuration as an independent risk factor for aneurysm...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-08-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2019.00844/full |
| _version_ | 1811282362249510912 |
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| author | Qinglin Liu Qinglin Liu Peng Jiang Yuhua Jiang Yuhua Jiang Shaolin Li Huijian Ge Huijian Ge Hengwei Jin Hengwei Jin Youxiang Li Youxiang Li |
| author_facet | Qinglin Liu Qinglin Liu Peng Jiang Yuhua Jiang Yuhua Jiang Shaolin Li Huijian Ge Huijian Ge Hengwei Jin Hengwei Jin Youxiang Li Youxiang Li |
| author_sort | Qinglin Liu |
| collection | DOAJ |
| description | Background: Bifurcation and sidewall aneurysms have different rupture risks, but whether this difference comes from the location of the aneurysm is not clear. The objective of this study is to illustrate the rationality of ranking bifurcation configuration as an independent risk factor for aneurysm rupture.Methods: Morphological features of 719 aneurysms (216 ruptured) were automatically extracted from a consecutive cohort of patients via PyRadiomics. Rupture risks and morphological features were compared between bifurcation and sidewall aneurysms, and lasso regression was applied to explore the morphological determinants for rupture in bifurcation and sidewall aneurysms. Rupture risks and morphological features of bifurcation aneurysms in different locations were analyzed. Multivariate regression was performed to explore the risk factors for aneurysm rupture.Results: Twelve morphological features were automatically extracted from PyRadiomics implemented in Python. The rupture risks were higher in bifurcation aneurysms (P < 0.01), and morphological features Elongation and Flatness were much lower in ruptured bifurcation than sidewall aneurysms (P = 0.036, 0.011, respectively). Elongation and Flatness were the morphological determinants for rupture in bifurcation aneurysms, whereas Elongation and SphericalDisproportion were determinants for sidewall aneurysms. Different rupture risks and morphological features were found between sidewall and bifurcation aneurysms of the same location, and among bifurcation aneurysms of different locations. In multivariate regression, bifurcation configuration was an independent risk factor for aneurysm rupture (OR 3.007, 95% CI 1.752–5.248, P < 0.001).Conclusions: Sidewall and bifurcation aneurysms and bifurcation aneurysms of different locations have different rupture risks and morphological features. Bifurcation configuration is an independent risk factor for aneurysm rupture irrespective of location. |
| first_indexed | 2024-04-13T01:50:10Z |
| format | Article |
| id | doaj.art-f511ca27870d44848d7817b6da951b29 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-13T01:50:10Z |
| publishDate | 2019-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-f511ca27870d44848d7817b6da951b292022-12-22T03:07:54ZengFrontiers Media S.A.Frontiers in Neurology1664-22952019-08-011010.3389/fneur.2019.00844466684Bifurcation Configuration Is an Independent Risk Factor for Aneurysm Rupture Irrespective of LocationQinglin Liu0Qinglin Liu1Peng Jiang2Yuhua Jiang3Yuhua Jiang4Shaolin Li5Huijian Ge6Huijian Ge7Hengwei Jin8Hengwei Jin9Youxiang Li10Youxiang Li11Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaBeijing Neurointerventional Engineering Center, Beijing, ChinaDepartment of Interventional Neuroradiology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Interventional Neuroradiology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaBeijing Neurointerventional Engineering Center, Beijing, ChinaDepartment of Interventional Neuroradiology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Interventional Neuroradiology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaBeijing Neurointerventional Engineering Center, Beijing, ChinaDepartment of Interventional Neuroradiology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaBeijing Neurointerventional Engineering Center, Beijing, ChinaDepartment of Interventional Neuroradiology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaBeijing Neurointerventional Engineering Center, Beijing, ChinaBackground: Bifurcation and sidewall aneurysms have different rupture risks, but whether this difference comes from the location of the aneurysm is not clear. The objective of this study is to illustrate the rationality of ranking bifurcation configuration as an independent risk factor for aneurysm rupture.Methods: Morphological features of 719 aneurysms (216 ruptured) were automatically extracted from a consecutive cohort of patients via PyRadiomics. Rupture risks and morphological features were compared between bifurcation and sidewall aneurysms, and lasso regression was applied to explore the morphological determinants for rupture in bifurcation and sidewall aneurysms. Rupture risks and morphological features of bifurcation aneurysms in different locations were analyzed. Multivariate regression was performed to explore the risk factors for aneurysm rupture.Results: Twelve morphological features were automatically extracted from PyRadiomics implemented in Python. The rupture risks were higher in bifurcation aneurysms (P < 0.01), and morphological features Elongation and Flatness were much lower in ruptured bifurcation than sidewall aneurysms (P = 0.036, 0.011, respectively). Elongation and Flatness were the morphological determinants for rupture in bifurcation aneurysms, whereas Elongation and SphericalDisproportion were determinants for sidewall aneurysms. Different rupture risks and morphological features were found between sidewall and bifurcation aneurysms of the same location, and among bifurcation aneurysms of different locations. In multivariate regression, bifurcation configuration was an independent risk factor for aneurysm rupture (OR 3.007, 95% CI 1.752–5.248, P < 0.001).Conclusions: Sidewall and bifurcation aneurysms and bifurcation aneurysms of different locations have different rupture risks and morphological features. Bifurcation configuration is an independent risk factor for aneurysm rupture irrespective of location.https://www.frontiersin.org/article/10.3389/fneur.2019.00844/fullintracranial aneurysmsrisk assessmentbifurcationsidewallmorphology |
| spellingShingle | Qinglin Liu Qinglin Liu Peng Jiang Yuhua Jiang Yuhua Jiang Shaolin Li Huijian Ge Huijian Ge Hengwei Jin Hengwei Jin Youxiang Li Youxiang Li Bifurcation Configuration Is an Independent Risk Factor for Aneurysm Rupture Irrespective of Location Frontiers in Neurology intracranial aneurysms risk assessment bifurcation sidewall morphology |
| title | Bifurcation Configuration Is an Independent Risk Factor for Aneurysm Rupture Irrespective of Location |
| title_full | Bifurcation Configuration Is an Independent Risk Factor for Aneurysm Rupture Irrespective of Location |
| title_fullStr | Bifurcation Configuration Is an Independent Risk Factor for Aneurysm Rupture Irrespective of Location |
| title_full_unstemmed | Bifurcation Configuration Is an Independent Risk Factor for Aneurysm Rupture Irrespective of Location |
| title_short | Bifurcation Configuration Is an Independent Risk Factor for Aneurysm Rupture Irrespective of Location |
| title_sort | bifurcation configuration is an independent risk factor for aneurysm rupture irrespective of location |
| topic | intracranial aneurysms risk assessment bifurcation sidewall morphology |
| url | https://www.frontiersin.org/article/10.3389/fneur.2019.00844/full |
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