Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems

Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems

Non-alcoholic fatty liver disease (NAFLD) is a health concern affecting 24% of the population worldwide. Although the pathophysiologic mechanisms underlying disease are not fully clarified, mitochondrial dysfunction and oxidative stress are key players in disease progression. Consequently, efforts t...

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Bibliographic Details
Main Authors: Ricardo Amorim, Inês C.M. Simões, José Teixeira, Fernando Cagide, Yaiza Potes, Pedro Soares, Adriana Carvalho, Ludgero C. Tavares, Sofia Benfeito, Susana P. Pereira, Rui F. Simões, Agnieszka Karkucinska-Wieckowska, Ivan Viegas, Sylwia Szymanska, Michał Dąbrowski, Justyna Janikiewicz, Teresa Cunha-Oliveira, Agnieszka Dobrzyń, John G. Jones, Fernanda Borges, Mariusz R. Wieckowski, Paulo J. Oliveira
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722001720

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