Effects of neuropeptide Y on electrical activity and myocardial contractility
Neuropeptide Y (NPY) and agonist Leu(31)Pro(34)NPY were used to determine the type of NPY receptors involved in electrical activity and myocardial contraction. The experiments on the electrical activity of the right atrium showed that NPY and the selective agonist had negative inotropic and chronotr...
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| Format: | Article |
| Language: | English |
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Kazan Federal University
2018-12-01
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| Series: | Učënye Zapiski Kazanskogo Universiteta. Seriâ Estestvennye Nauki |
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| Online Access: | https://kpfu.ru/effects-of-neuropeptide-y-on-electrical-activity_382284.html |
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| author | A.A. Zverev T.A. Anikina N.G. Iskakov A.V. Krulova P.M. Masliukov J.P. Timmermans T.L. Zefirov |
| author_facet | A.A. Zverev T.A. Anikina N.G. Iskakov A.V. Krulova P.M. Masliukov J.P. Timmermans T.L. Zefirov |
| author_sort | A.A. Zverev |
| collection | DOAJ |
| description | Neuropeptide Y (NPY) and agonist Leu(31)Pro(34)NPY were used to determine the type of NPY receptors involved in electrical activity and myocardial contraction. The experiments on the electrical activity of the right atrium showed that NPY and the selective agonist had negative inotropic and chronotropic actions through the activation of NPY1 receptor. The activation of NPY-receptors of right atrial cardiomyocytes with NPY leads to a change of the membrane potential and the amplitude-time parameters of the action potential. The experiments with the myocardial strips showed that NPY and the agonist produced the most potent effect at a concentration of 10–7 M. At this concentration, Leu(31)Pro(34)NPY showed the greatest positive inotropic effect on the contraction of the atria and ventricles. |
| first_indexed | 2024-03-13T07:14:30Z |
| format | Article |
| id | doaj.art-f512eff021bd46b88f85d2f4b55bef9c |
| institution | Directory Open Access Journal |
| issn | 2542-064X 2500-218X |
| language | English |
| last_indexed | 2024-03-13T07:14:30Z |
| publishDate | 2018-12-01 |
| publisher | Kazan Federal University |
| record_format | Article |
| series | Učënye Zapiski Kazanskogo Universiteta. Seriâ Estestvennye Nauki |
| spelling | doaj.art-f512eff021bd46b88f85d2f4b55bef9c2023-06-05T12:55:17ZengKazan Federal UniversityUčënye Zapiski Kazanskogo Universiteta. Seriâ Estestvennye Nauki2542-064X2500-218X2018-12-011604601612Effects of neuropeptide Y on electrical activity and myocardial contractilityA.A. Zverev0T.A. Anikina1N.G. Iskakov2A.V. Krulova3P.M. Masliukov4J.P. Timmermans5T.L. Zefirov6Kazan Federal University, Kazan, 420008 RussiaKazan Federal University, Kazan, 420008 RussiaKazan Federal University, Kazan, 420008 RussiaKazan Federal University, Kazan, 420008 RussiaYaroslavl State Medical University, Yaroslavl, 150000 RussiaUniversity of Antwerp, Antwerp, 2000, BelgiumKazan Federal University, Kazan, 420008 RussiaNeuropeptide Y (NPY) and agonist Leu(31)Pro(34)NPY were used to determine the type of NPY receptors involved in electrical activity and myocardial contraction. The experiments on the electrical activity of the right atrium showed that NPY and the selective agonist had negative inotropic and chronotropic actions through the activation of NPY1 receptor. The activation of NPY-receptors of right atrial cardiomyocytes with NPY leads to a change of the membrane potential and the amplitude-time parameters of the action potential. The experiments with the myocardial strips showed that NPY and the agonist produced the most potent effect at a concentration of 10–7 M. At this concentration, Leu(31)Pro(34)NPY showed the greatest positive inotropic effect on the contraction of the atria and ventricles.https://kpfu.ru/effects-of-neuropeptide-y-on-electrical-activity_382284.htmlneuropeptide yaction potentialcontractilityrats |
| spellingShingle | A.A. Zverev T.A. Anikina N.G. Iskakov A.V. Krulova P.M. Masliukov J.P. Timmermans T.L. Zefirov Effects of neuropeptide Y on electrical activity and myocardial contractility Učënye Zapiski Kazanskogo Universiteta. Seriâ Estestvennye Nauki neuropeptide y action potential contractility rats |
| title | Effects of neuropeptide Y on electrical activity and myocardial contractility |
| title_full | Effects of neuropeptide Y on electrical activity and myocardial contractility |
| title_fullStr | Effects of neuropeptide Y on electrical activity and myocardial contractility |
| title_full_unstemmed | Effects of neuropeptide Y on electrical activity and myocardial contractility |
| title_short | Effects of neuropeptide Y on electrical activity and myocardial contractility |
| title_sort | effects of neuropeptide y on electrical activity and myocardial contractility |
| topic | neuropeptide y action potential contractility rats |
| url | https://kpfu.ru/effects-of-neuropeptide-y-on-electrical-activity_382284.html |
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