Nomogram based on albumin-bilirubin grade to predict outcome of the patients with hepatitis C virus-related hepatocellular carcinoma after microwave ablation
ObjectiveTo construct a nomogram based on the albumin-bilirubin (ALBI) grade to provide prognostic value for hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) patients who underwent ultrasound-guided percutaneous microwave ablation (US-PMWA).MethodsFrom April 2005 to January 2018, 183 t...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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China Anti-Cancer Association
2019-12-01
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| Series: | Cancer Biology & Medicine |
| Subjects: | |
| Online Access: | http://www.cancerbiomed.org/index.php/cocr/article/view/1501 |
| _version_ | 1818368454651019264 |
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| author | Chao An Xin Li Xiaoling Yu Zhigang Cheng Zhiyu Han Fangyi Liu Jie Yu Ping Liang |
| author_facet | Chao An Xin Li Xiaoling Yu Zhigang Cheng Zhiyu Han Fangyi Liu Jie Yu Ping Liang |
| author_sort | Chao An |
| collection | DOAJ |
| description | ObjectiveTo construct a nomogram based on the albumin-bilirubin (ALBI) grade to provide prognostic value for hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) patients who underwent ultrasound-guided percutaneous microwave ablation (US-PMWA).MethodsFrom April 2005 to January 2018, 183 treatment-naïve patients with 251 HCV-related HCCs according to the Milan criteria received US-PMWA subsequently. The overall survival (OS) and recurrence-free survival (RFS) were compared between groups classified by ALBI grade. Cox proportional hazard regression model based on risk factors for survival and recurrence was used to construct the nomogram.ResultsThe cumulative OS rates at 1-, 3-, 5- and 10-year were 97.7%, 73.6%, 54.5% and 34.5%, respectively. Stratified according to ALBI grade, the 1-, 3-, and 5-year OS in the ALBI grade 1 group and grade 2 group were 99.2%, 92.4%, 77.9% and 97.7%, 52.3%, 38.6%, respectively, with significant statistical difference (P < 0.001). No significant statistical difference was detected in the 1-, 3-, and 5-year RFS rates in the ALBI grade 1 group and grade 2 group (P = 0.220). The major complication rate was 1.6%. Multivariate analysis results showed age, α-fetoprotein level, tumor number, platelet count, location, Child-Turcotte-Pugh (CTP) and ALBI grade were associated with OS, which generated the nomograms. Internal validation with 1000 bootstrapped sample sets had good concordance index of 0.769 (95%CI 0.699-0.839) in OS.ConclusionsThis nomogram based on ALBI grade was a visualization risk model, which could provide personalized prediction of long-term outcomes for HCV-related HCC patients after US-PMWA. |
| first_indexed | 2024-12-13T23:08:12Z |
| format | Article |
| id | doaj.art-f5130c895dc94092a39ef4bac35bc017 |
| institution | Directory Open Access Journal |
| issn | 2095-3941 2095-3941 |
| language | English |
| last_indexed | 2024-12-13T23:08:12Z |
| publishDate | 2019-12-01 |
| publisher | China Anti-Cancer Association |
| record_format | Article |
| series | Cancer Biology & Medicine |
| spelling | doaj.art-f5130c895dc94092a39ef4bac35bc0172022-12-21T23:28:12ZengChina Anti-Cancer AssociationCancer Biology & Medicine2095-39412095-39412019-12-0116479781010.20892/j.issn.2095-3941.2018.0486CBM-2018-0486Nomogram based on albumin-bilirubin grade to predict outcome of the patients with hepatitis C virus-related hepatocellular carcinoma after microwave ablationChao AnXin LiXiaoling Yu0Zhigang Cheng1Zhiyu Han2Fangyi Liu3Jie Yu4Ping Liang5Department of Interventional Ultrasound, State Key Laboratory of Kidney Disease, The Chinese PLA General Hospital, Beijing 100853, ChinaDepartment of Interventional Ultrasound, State Key Laboratory of Kidney Disease, The Chinese PLA General Hospital, Beijing 100853, ChinaDepartment of Interventional Ultrasound, State Key Laboratory of Kidney Disease, The Chinese PLA General Hospital, Beijing 100853, ChinaDepartment of Interventional Ultrasound, State Key Laboratory of Kidney Disease, The Chinese PLA General Hospital, Beijing 100853, ChinaDepartment of Interventional Ultrasound, State Key Laboratory of Kidney Disease, The Chinese PLA General Hospital, Beijing 100853, ChinaDepartment of Interventional Ultrasound, State Key Laboratory of Kidney Disease, The Chinese PLA General Hospital, Beijing 100853, ChinaObjectiveTo construct a nomogram based on the albumin-bilirubin (ALBI) grade to provide prognostic value for hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) patients who underwent ultrasound-guided percutaneous microwave ablation (US-PMWA).MethodsFrom April 2005 to January 2018, 183 treatment-naïve patients with 251 HCV-related HCCs according to the Milan criteria received US-PMWA subsequently. The overall survival (OS) and recurrence-free survival (RFS) were compared between groups classified by ALBI grade. Cox proportional hazard regression model based on risk factors for survival and recurrence was used to construct the nomogram.ResultsThe cumulative OS rates at 1-, 3-, 5- and 10-year were 97.7%, 73.6%, 54.5% and 34.5%, respectively. Stratified according to ALBI grade, the 1-, 3-, and 5-year OS in the ALBI grade 1 group and grade 2 group were 99.2%, 92.4%, 77.9% and 97.7%, 52.3%, 38.6%, respectively, with significant statistical difference (P < 0.001). No significant statistical difference was detected in the 1-, 3-, and 5-year RFS rates in the ALBI grade 1 group and grade 2 group (P = 0.220). The major complication rate was 1.6%. Multivariate analysis results showed age, α-fetoprotein level, tumor number, platelet count, location, Child-Turcotte-Pugh (CTP) and ALBI grade were associated with OS, which generated the nomograms. Internal validation with 1000 bootstrapped sample sets had good concordance index of 0.769 (95%CI 0.699-0.839) in OS.ConclusionsThis nomogram based on ALBI grade was a visualization risk model, which could provide personalized prediction of long-term outcomes for HCV-related HCC patients after US-PMWA.http://www.cancerbiomed.org/index.php/cocr/article/view/1501nomogramalbumin-bilirubin gradehepatitis c virushepatocellular carcinomamicrowave ablation |
| spellingShingle | Chao An Xin Li Xiaoling Yu Zhigang Cheng Zhiyu Han Fangyi Liu Jie Yu Ping Liang Nomogram based on albumin-bilirubin grade to predict outcome of the patients with hepatitis C virus-related hepatocellular carcinoma after microwave ablation Cancer Biology & Medicine nomogram albumin-bilirubin grade hepatitis c virus hepatocellular carcinoma microwave ablation |
| title | Nomogram based on albumin-bilirubin grade to predict outcome of the patients with hepatitis C virus-related hepatocellular carcinoma after microwave ablation |
| title_full | Nomogram based on albumin-bilirubin grade to predict outcome of the patients with hepatitis C virus-related hepatocellular carcinoma after microwave ablation |
| title_fullStr | Nomogram based on albumin-bilirubin grade to predict outcome of the patients with hepatitis C virus-related hepatocellular carcinoma after microwave ablation |
| title_full_unstemmed | Nomogram based on albumin-bilirubin grade to predict outcome of the patients with hepatitis C virus-related hepatocellular carcinoma after microwave ablation |
| title_short | Nomogram based on albumin-bilirubin grade to predict outcome of the patients with hepatitis C virus-related hepatocellular carcinoma after microwave ablation |
| title_sort | nomogram based on albumin bilirubin grade to predict outcome of the patients with hepatitis c virus related hepatocellular carcinoma after microwave ablation |
| topic | nomogram albumin-bilirubin grade hepatitis c virus hepatocellular carcinoma microwave ablation |
| url | http://www.cancerbiomed.org/index.php/cocr/article/view/1501 |
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