Anti-oxidative Effects of Butanol Seed Extract of Parkinsonia aculeata on Carbon Tetrachloride-Induced Liver Damage on Wistar Rats
Medicinal plants have protective effect because of the presence of several compounds which have different mechanism of action. This study sought to assess the anti-oxidative effects of butanol seed extract of Parkinsonia aculeata on carbon tetrachloride (CCl4)-induced liver damage on Wistar rats. Th...
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| Format: | Article |
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State Islamic University Sunan Kalijaga
2022-06-01
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| Series: | Biology, Medicine & Natural Product Chemistry |
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| Online Access: | https://sciencebiology.org/index.php/BIOMEDICH/article/view/193 |
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| author | Muhammad Bashiru AbdulRahman Yusuf Gumburawa Malami Sanusi Wara Hassan Mansur Lawal Waliu Temitope Adanlawo Mansur Mohammed Birnin Kebbi Kamaldeen Olalekan Sanusi |
| author_facet | Muhammad Bashiru AbdulRahman Yusuf Gumburawa Malami Sanusi Wara Hassan Mansur Lawal Waliu Temitope Adanlawo Mansur Mohammed Birnin Kebbi Kamaldeen Olalekan Sanusi |
| author_sort | Muhammad Bashiru AbdulRahman |
| collection | DOAJ |
| description | Medicinal plants have protective effect because of the presence of several compounds which have different mechanism of action. This study sought to assess the anti-oxidative effects of butanol seed extract of Parkinsonia aculeata on carbon tetrachloride (CCl4)-induced liver damage on Wistar rats. The Wistar rats were put into five groups, each with six rats: Group A received a daily dosage of liquid paraffin (1ml/kg); Group B received 1ml/kg body weight of CCl4 (30% in liquid paraffin intraperitoneal); Group C, D, and E received the seed extracts at 100, 120, and 160 mg/kg every day for two weeks. Induction of CCl4 was three times a week for two weeks simultaneously with the extract to the last day. After sacrificed, the liver was harvested and homogenized, and used for further analyses. There was a significant increase (p<0.05) in the levels of superoxide dismutase and catalase in all extract treated groups compared to positive control, except the catalase levels of group treated with 160mg/kg. Similar results was observed in vitamin C, vitamin E and glutathione in rats treated with 100 and 120mg/kg of the extract. The results of this study revealed that butanol seed extract from P. aculeata has antioxidant properties and can protect Wistar rats' livers from the damaging effects of CCl4. |
| first_indexed | 2024-12-10T21:15:32Z |
| format | Article |
| id | doaj.art-f513d776a76446668fb6a607173e6e75 |
| institution | Directory Open Access Journal |
| issn | 2089-6514 2540-9328 |
| language | English |
| last_indexed | 2024-12-10T21:15:32Z |
| publishDate | 2022-06-01 |
| publisher | State Islamic University Sunan Kalijaga |
| record_format | Article |
| series | Biology, Medicine & Natural Product Chemistry |
| spelling | doaj.art-f513d776a76446668fb6a607173e6e752022-12-22T01:33:20ZengState Islamic University Sunan KalijagaBiology, Medicine & Natural Product Chemistry2089-65142540-93282022-06-01111838710.14421/biomedich.2022.111.83-87133Anti-oxidative Effects of Butanol Seed Extract of Parkinsonia aculeata on Carbon Tetrachloride-Induced Liver Damage on Wistar RatsMuhammad Bashiru AbdulRahman0Yusuf Gumburawa Malami1Sanusi Wara Hassan2Mansur Lawal3Waliu Temitope Adanlawo4Mansur Mohammed Birnin Kebbi5Kamaldeen Olalekan Sanusi6Usmanu Danfodiyo University, SokotoUmaru Ali Shinkafi Polytechnic, SokotoUsmanu Danfodiyo University, SokotoUsmanu Danfodiyo University, SokotoUsmanu Danfodiyo University Teaching Hospital, SokotoUsmanu Danfodiyo University Teaching Hospital, SokotoUsmanu Danfodiyo University, Sokoto.Medicinal plants have protective effect because of the presence of several compounds which have different mechanism of action. This study sought to assess the anti-oxidative effects of butanol seed extract of Parkinsonia aculeata on carbon tetrachloride (CCl4)-induced liver damage on Wistar rats. The Wistar rats were put into five groups, each with six rats: Group A received a daily dosage of liquid paraffin (1ml/kg); Group B received 1ml/kg body weight of CCl4 (30% in liquid paraffin intraperitoneal); Group C, D, and E received the seed extracts at 100, 120, and 160 mg/kg every day for two weeks. Induction of CCl4 was three times a week for two weeks simultaneously with the extract to the last day. After sacrificed, the liver was harvested and homogenized, and used for further analyses. There was a significant increase (p<0.05) in the levels of superoxide dismutase and catalase in all extract treated groups compared to positive control, except the catalase levels of group treated with 160mg/kg. Similar results was observed in vitamin C, vitamin E and glutathione in rats treated with 100 and 120mg/kg of the extract. The results of this study revealed that butanol seed extract from P. aculeata has antioxidant properties and can protect Wistar rats' livers from the damaging effects of CCl4.https://sciencebiology.org/index.php/BIOMEDICH/article/view/193antioxidantcarbon tetrachlorideliver damageoxidative stressparkinsonia aculeata |
| spellingShingle | Muhammad Bashiru AbdulRahman Yusuf Gumburawa Malami Sanusi Wara Hassan Mansur Lawal Waliu Temitope Adanlawo Mansur Mohammed Birnin Kebbi Kamaldeen Olalekan Sanusi Anti-oxidative Effects of Butanol Seed Extract of Parkinsonia aculeata on Carbon Tetrachloride-Induced Liver Damage on Wistar Rats Biology, Medicine & Natural Product Chemistry antioxidant carbon tetrachloride liver damage oxidative stress parkinsonia aculeata |
| title | Anti-oxidative Effects of Butanol Seed Extract of Parkinsonia aculeata on Carbon Tetrachloride-Induced Liver Damage on Wistar Rats |
| title_full | Anti-oxidative Effects of Butanol Seed Extract of Parkinsonia aculeata on Carbon Tetrachloride-Induced Liver Damage on Wistar Rats |
| title_fullStr | Anti-oxidative Effects of Butanol Seed Extract of Parkinsonia aculeata on Carbon Tetrachloride-Induced Liver Damage on Wistar Rats |
| title_full_unstemmed | Anti-oxidative Effects of Butanol Seed Extract of Parkinsonia aculeata on Carbon Tetrachloride-Induced Liver Damage on Wistar Rats |
| title_short | Anti-oxidative Effects of Butanol Seed Extract of Parkinsonia aculeata on Carbon Tetrachloride-Induced Liver Damage on Wistar Rats |
| title_sort | anti oxidative effects of butanol seed extract of parkinsonia aculeata on carbon tetrachloride induced liver damage on wistar rats |
| topic | antioxidant carbon tetrachloride liver damage oxidative stress parkinsonia aculeata |
| url | https://sciencebiology.org/index.php/BIOMEDICH/article/view/193 |
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