Polyhexamethylene guanidine phosphate increases stress granule formation in human 3D lung organoids under respiratory syncytial virus infection

Polyhexamethylene guanidine phosphate increases stress granule formation in human 3D lung organoids under respiratory syncytial virus infection

Polyhexamethylene guanidine phosphate (PHMG-p), a humidifier disinfectant, is known to cause lung toxicity, including inflammation and pulmonary fibrosis. In this study, we aimed to investigate the effect of PHMG-p on human lung tissue models (2D epithelial cells and 3D organoids) under conditions o...

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Bibliographic Details
Main Authors: Seri Choi, Sunkyung Choi, Yeongsoo Choi, Namjoon Cho, Seung-Yeon Kim, Chang Hyun Lee, Han-Jin Park, Won Keun Oh, Kee K. Kim, Eun-Mi Kim
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Ecotoxicology and Environmental Safety
Subjects:
DNA damage
eIF2α
Stress granules
Polyhexamethylene guanidine phosphate
Lung organoids
Pulmonary fibrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651321012069

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