Evolving towards a human-cell based and multiscale approach to drug discovery for CNS disorders

Evolving towards a human-cell based and multiscale approach to drug discovery for CNS disorders

A disruptive approach to therapeutic discovery and development is required in order to significantly improve the success rate of drug discovery for central nervous system (CNS) disorders. In this review, we first assess the key factors contributing to the frequent clinical failures for novel drugs....

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Bibliographic Details
Main Authors:	Eric eSchadt, Sean eBuchanan, Kristen eBrennand, Kalpana eMerchant
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2014-12-01
Series:	Frontiers in Pharmacology
Subjects:	high throughput biology systems biology and network biology Drug Discovery Screening complex disease mechanism stem cell based screening
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00252/full

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