Carnosic Acid Attenuates Cadmium Induced Nephrotoxicity by Inhibiting Oxidative Stress, Promoting Nrf2/HO-1 Signalling and Impairing TGF-β1/Smad/Collagen IV Signalling

Carnosic Acid Attenuates Cadmium Induced Nephrotoxicity by Inhibiting Oxidative Stress, Promoting Nrf2/HO-1 Signalling and Impairing TGF-β1/Smad/Collagen IV Signalling

Cadmium (Cd) imparts nephrotoxicity via triggering oxidative stress and pathological signal transductions in renal cells. The present study was performed to explore the protective mechanism of carnosic acid (CA), a naturally occurring antioxidant compound, against cadmium chloride (CdCl<sub>2&...

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Main Authors: Sonjit Das, Saikat Dewanjee, Tarun K. Dua, Swarnalata Joardar, Pratik Chakraborty, Shovonlal Bhowmick, Achintya Saha, Simanta Bhattacharjee, Vincenzo De Feo
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Molecules
Subjects:
antioxidant
cadmium chloride
carnosic acid
molecular docking
oxidative stress
Online Access:https://www.mdpi.com/1420-3049/24/22/4176

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