MMP-8 deficiency increases TLR/RAGE ligands S100A8 and S100A9 and exacerbates lung inflammation during endotoxemia.

MMP-8 deficiency increases TLR/RAGE ligands S100A8 and S100A9 and exacerbates lung inflammation during endotoxemia.

Matrix metalloproteinase-8, released mainly from neutrophils, is a critical regulator of the inflammatory response by its ability to cleave multiple mediators. Herein, we report the results of a model of endotoxemia after intraperitoneal LPS injection in mice lacking MMP-8 and their wildtype counter...

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Bibliographic Details
Main Authors: Adrián González-López, Alina Aguirre, Inés López-Alonso, Laura Amado, Aurora Astudillo, María Soledad Fernández-García, María F Suárez, Estefanía Batalla-Solís, Enrique Colado, Guillermo M Albaiceta
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3386945?pdf=render

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http://europepmc.org/articles/PMC3386945?pdf=render

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