Soluble Factors and Receptors Involved in Skin Innate Immunity—What Do We Know So Far?
The pattern recognition receptors, complement system, inflammasomes, antimicrobial peptides, and cytokines are innate immunity soluble factors. They sense, either directly or indirectly, the potential threats and produce inflammation and cellular death. High interest in their modulation has emerged...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/12/1795 |
| _version_ | 1797506558646550528 |
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| author | Lucian G. Scurtu Olga Simionescu |
| author_facet | Lucian G. Scurtu Olga Simionescu |
| author_sort | Lucian G. Scurtu |
| collection | DOAJ |
| description | The pattern recognition receptors, complement system, inflammasomes, antimicrobial peptides, and cytokines are innate immunity soluble factors. They sense, either directly or indirectly, the potential threats and produce inflammation and cellular death. High interest in their modulation has emerged lately, acknowledging they are involved in many cutaneous inflammatory, infectious, and neoplastic disorders. We extensively reviewed the implication of soluble factors in skin innate immunity. Furthermore, we showed which molecules target these factors, how these molecules work, and how they have been used in dermatological practice. Cytokine inhibitors have paved the way to a new era in treating moderate to severe psoriasis and atopic dermatitis. |
| first_indexed | 2024-03-10T04:34:16Z |
| format | Article |
| id | doaj.art-f51fe49d2d0146a9a722b7614c906d08 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T04:34:16Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-f51fe49d2d0146a9a722b7614c906d082023-11-23T03:55:41ZengMDPI AGBiomedicines2227-90592021-11-01912179510.3390/biomedicines9121795Soluble Factors and Receptors Involved in Skin Innate Immunity—What Do We Know So Far?Lucian G. Scurtu0Olga Simionescu1Department of Dermatology, “Carol Davila” University of Medicine and Pharmacy, Colentina Hospital, 19-21 Stefan cel Mare Road, 020125 Bucharest, RomaniaDepartment of Dermatology, “Carol Davila” University of Medicine and Pharmacy, Colentina Hospital, 19-21 Stefan cel Mare Road, 020125 Bucharest, RomaniaThe pattern recognition receptors, complement system, inflammasomes, antimicrobial peptides, and cytokines are innate immunity soluble factors. They sense, either directly or indirectly, the potential threats and produce inflammation and cellular death. High interest in their modulation has emerged lately, acknowledging they are involved in many cutaneous inflammatory, infectious, and neoplastic disorders. We extensively reviewed the implication of soluble factors in skin innate immunity. Furthermore, we showed which molecules target these factors, how these molecules work, and how they have been used in dermatological practice. Cytokine inhibitors have paved the way to a new era in treating moderate to severe psoriasis and atopic dermatitis.https://www.mdpi.com/2227-9059/9/12/1795innate immunitypattern recognition receptorscytokinesinflammasomescomplementantimicrobial peptides |
| spellingShingle | Lucian G. Scurtu Olga Simionescu Soluble Factors and Receptors Involved in Skin Innate Immunity—What Do We Know So Far? Biomedicines innate immunity pattern recognition receptors cytokines inflammasomes complement antimicrobial peptides |
| title | Soluble Factors and Receptors Involved in Skin Innate Immunity—What Do We Know So Far? |
| title_full | Soluble Factors and Receptors Involved in Skin Innate Immunity—What Do We Know So Far? |
| title_fullStr | Soluble Factors and Receptors Involved in Skin Innate Immunity—What Do We Know So Far? |
| title_full_unstemmed | Soluble Factors and Receptors Involved in Skin Innate Immunity—What Do We Know So Far? |
| title_short | Soluble Factors and Receptors Involved in Skin Innate Immunity—What Do We Know So Far? |
| title_sort | soluble factors and receptors involved in skin innate immunity what do we know so far |
| topic | innate immunity pattern recognition receptors cytokines inflammasomes complement antimicrobial peptides |
| url | https://www.mdpi.com/2227-9059/9/12/1795 |
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