Expression of Monocarboxylate Transporter 1 in Immunosuppressive Macrophages Is Associated With the Poor Prognosis in Breast Cancer
Monocarboxylate transporter 1 (MCT1) participates in the transport of lactate to facilitate metabolic reprogramming during tumor progression. Tumor-associated macrophages (TAMs) are also involved in the inflammatory adaptation of the tumor microenvironment (TME). This study aimed to determine the co...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.574787/full |
| _version_ | 1819266572999458816 |
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| author | Bei Li Bei Li Qian Yang Zhiyu Li Zhiliang Xu Si Sun Qi Wu Shengrong Sun |
| author_facet | Bei Li Bei Li Qian Yang Zhiyu Li Zhiliang Xu Si Sun Qi Wu Shengrong Sun |
| author_sort | Bei Li |
| collection | DOAJ |
| description | Monocarboxylate transporter 1 (MCT1) participates in the transport of lactate to facilitate metabolic reprogramming during tumor progression. Tumor-associated macrophages (TAMs) are also involved in the inflammatory adaptation of the tumor microenvironment (TME). This study aimed to determine the correlation between metabolite changes and the polarization of macrophages in the TME. We demonstrated that the expression of CD163 on macrophages was significantly higher in breast cancer tissues than in normal tissues, especially in the HER2 subtype, although it was not statistically associated with recurrence-free survival (RFS). The presence of MCT1+ and CD163+ macrophages in the invasive margin was significantly correlated with decreased RFS. A significant correlation existed between MCT1 and CD163 expression in the margin, and high infiltration of MCT1+CD163+ macrophages into the margin predicted rapid progression and poor survival outcomes for breast cancer patients. These data suggested that MCT1 at least partially promoted the alternative polarization of macrophages to inhibit antitumor immunity, and blocking this interaction may be a promising method for breast cancer therapy. |
| first_indexed | 2024-12-23T21:03:25Z |
| format | Article |
| id | doaj.art-f5206798a1bd4aa199cdfbc59af12dc2 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-23T21:03:25Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Oncology |
| spelling | doaj.art-f5206798a1bd4aa199cdfbc59af12dc22022-12-21T17:31:19ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-10-011010.3389/fonc.2020.574787574787Expression of Monocarboxylate Transporter 1 in Immunosuppressive Macrophages Is Associated With the Poor Prognosis in Breast CancerBei Li0Bei Li1Qian Yang2Zhiyu Li3Zhiliang Xu4Si Sun5Qi Wu6Shengrong Sun7Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaMonocarboxylate transporter 1 (MCT1) participates in the transport of lactate to facilitate metabolic reprogramming during tumor progression. Tumor-associated macrophages (TAMs) are also involved in the inflammatory adaptation of the tumor microenvironment (TME). This study aimed to determine the correlation between metabolite changes and the polarization of macrophages in the TME. We demonstrated that the expression of CD163 on macrophages was significantly higher in breast cancer tissues than in normal tissues, especially in the HER2 subtype, although it was not statistically associated with recurrence-free survival (RFS). The presence of MCT1+ and CD163+ macrophages in the invasive margin was significantly correlated with decreased RFS. A significant correlation existed between MCT1 and CD163 expression in the margin, and high infiltration of MCT1+CD163+ macrophages into the margin predicted rapid progression and poor survival outcomes for breast cancer patients. These data suggested that MCT1 at least partially promoted the alternative polarization of macrophages to inhibit antitumor immunity, and blocking this interaction may be a promising method for breast cancer therapy.https://www.frontiersin.org/article/10.3389/fonc.2020.574787/fullbreast cancertumor-associated macrophageMCT1CD163recurrence-free survival |
| spellingShingle | Bei Li Bei Li Qian Yang Zhiyu Li Zhiliang Xu Si Sun Qi Wu Shengrong Sun Expression of Monocarboxylate Transporter 1 in Immunosuppressive Macrophages Is Associated With the Poor Prognosis in Breast Cancer Frontiers in Oncology breast cancer tumor-associated macrophage MCT1 CD163 recurrence-free survival |
| title | Expression of Monocarboxylate Transporter 1 in Immunosuppressive Macrophages Is Associated With the Poor Prognosis in Breast Cancer |
| title_full | Expression of Monocarboxylate Transporter 1 in Immunosuppressive Macrophages Is Associated With the Poor Prognosis in Breast Cancer |
| title_fullStr | Expression of Monocarboxylate Transporter 1 in Immunosuppressive Macrophages Is Associated With the Poor Prognosis in Breast Cancer |
| title_full_unstemmed | Expression of Monocarboxylate Transporter 1 in Immunosuppressive Macrophages Is Associated With the Poor Prognosis in Breast Cancer |
| title_short | Expression of Monocarboxylate Transporter 1 in Immunosuppressive Macrophages Is Associated With the Poor Prognosis in Breast Cancer |
| title_sort | expression of monocarboxylate transporter 1 in immunosuppressive macrophages is associated with the poor prognosis in breast cancer |
| topic | breast cancer tumor-associated macrophage MCT1 CD163 recurrence-free survival |
| url | https://www.frontiersin.org/article/10.3389/fonc.2020.574787/full |
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