The role of Leu260Phe polymorphism of the receptor gene to GLP-1 incretin in the pathogenesis of diabetes type 2 diabetes with obesity

The role of Leu260Phe polymorphism of the receptor gene to GLP-1 incretin in the pathogenesis of diabetes type 2 diabetes with obesity

BACKGROUND: Glucagon-like peptide-1 (GLP-1) stimulates the proliferation of β-cells, enhances their resistance to apoptosis and increases glucose-dependent insulin secretion. AIMS: Study of the relationship of Leu260Phe polymorphism (rs1042044) of the GLP-1R gene with postprandial hormone p...

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Bibliographic Details
Main Authors: Daria A. Skuratovskaia, Maria A. Vulf, Elena V. Kirienkova, Natalia I. Myronyuk, Pavel A. Zatolokin, Larisa S. Litvinova
Format: Article
Language:English
Published: Endocrinology Research Centre 2019-08-01
Series:Сахарный диабет
Subjects:
type 2 diabetes
obesity
polymorphism
glp-1r
insulin
ghrelin
Online Access:https://www.dia-endojournals.ru/jour/article/view/9974

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