Systematic Literature Review of Herpes Zoster Disease Burden in Southeast Asia
Abstract Introduction Herpes zoster (HZ; i.e., shingles) is caused by the reactivation of varicella zoster virus leading to a painful dermatomal rash. An increasing trend in cases of HZ is evident worldwide; however, there is a lack of comprehensive reviews for Southeast Asian countries. Methods We...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2023-06-01
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| Series: | Infectious Diseases and Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s40121-023-00822-0 |
| _version_ | 1827916819379257344 |
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| author | Peter San Martin Kobkul Aunhachoke Maria Christina Filomena Batac Kris Lodrono-Lim Chanida Kwanthitinan Dicky Santoso Thanabalan Fonseka Minh Nguyen Adriana Guzman-Holst |
| author_facet | Peter San Martin Kobkul Aunhachoke Maria Christina Filomena Batac Kris Lodrono-Lim Chanida Kwanthitinan Dicky Santoso Thanabalan Fonseka Minh Nguyen Adriana Guzman-Holst |
| author_sort | Peter San Martin |
| collection | DOAJ |
| description | Abstract Introduction Herpes zoster (HZ; i.e., shingles) is caused by the reactivation of varicella zoster virus leading to a painful dermatomal rash. An increasing trend in cases of HZ is evident worldwide; however, there is a lack of comprehensive reviews for Southeast Asian countries. Methods We performed a systematic literature review of articles published until May 2022 that reported HZ epidemiology, clinical management, and health economic data in six Southeast Asian countries: Indonesia, Malaysia, the Philippines, Singapore, Thailand, and Vietnam. Literature searches were conducted in Medline, Scopus, Embase, and gray literature. Articles written in English or local languages were considered for inclusion. Results In total, 72 publications were included in the study; 22 were case studies and over 60% originated in Singapore and Thailand. Only two studies (data from Thailand) reported incidence of HZ. The proportion of patients reported with HZ was 0.68–0.7% among dermatology clinics, 0.14% at one emergency department (5.3% of dermatology cases) in Singapore, and 3% of admissions at another hospital in Singapore. Pain was the most common symptom associated with HZ, reported in 74.21–100% of patients. HZ complications were reported in 10.2–21.2% of patients, and the proportions with postherpetic neuralgia and HZ ophthalmicus were 6.3–50% and 4.98–28.57%, respectively. Additionally, there is a lack of comprehensive, up-to-date HZ economic data, with only six studies identified for the Philippines, Singapore, and Thailand. Conclusions Overall, there are limited data reporting incidence and prevalence of HZ in Southeast Asia at a national level. High rates of complications, symptoms, and abundance of case reports suggest substantial healthcare resource utilization for patients with HZ and highlight the need for further research in Southeast Asia assessing the societal impact. |
| first_indexed | 2024-03-13T03:20:44Z |
| format | Article |
| id | doaj.art-f5225dafd9344dafaed3d4c92a887359 |
| institution | Directory Open Access Journal |
| issn | 2193-8229 2193-6382 |
| language | English |
| last_indexed | 2024-03-13T03:20:44Z |
| publishDate | 2023-06-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Infectious Diseases and Therapy |
| spelling | doaj.art-f5225dafd9344dafaed3d4c92a8873592023-06-25T11:23:33ZengAdis, Springer HealthcareInfectious Diseases and Therapy2193-82292193-63822023-06-011261553157810.1007/s40121-023-00822-0Systematic Literature Review of Herpes Zoster Disease Burden in Southeast AsiaPeter San Martin0Kobkul Aunhachoke1Maria Christina Filomena Batac2Kris Lodrono-Lim3Chanida Kwanthitinan4Dicky Santoso5Thanabalan Fonseka6Minh Nguyen7Adriana Guzman-Holst8GSK VaccinesPhramongkutklao HospitalUniversity of the Philippines ManilaGSKGSKGSKGSKGSKGSKAbstract Introduction Herpes zoster (HZ; i.e., shingles) is caused by the reactivation of varicella zoster virus leading to a painful dermatomal rash. An increasing trend in cases of HZ is evident worldwide; however, there is a lack of comprehensive reviews for Southeast Asian countries. Methods We performed a systematic literature review of articles published until May 2022 that reported HZ epidemiology, clinical management, and health economic data in six Southeast Asian countries: Indonesia, Malaysia, the Philippines, Singapore, Thailand, and Vietnam. Literature searches were conducted in Medline, Scopus, Embase, and gray literature. Articles written in English or local languages were considered for inclusion. Results In total, 72 publications were included in the study; 22 were case studies and over 60% originated in Singapore and Thailand. Only two studies (data from Thailand) reported incidence of HZ. The proportion of patients reported with HZ was 0.68–0.7% among dermatology clinics, 0.14% at one emergency department (5.3% of dermatology cases) in Singapore, and 3% of admissions at another hospital in Singapore. Pain was the most common symptom associated with HZ, reported in 74.21–100% of patients. HZ complications were reported in 10.2–21.2% of patients, and the proportions with postherpetic neuralgia and HZ ophthalmicus were 6.3–50% and 4.98–28.57%, respectively. Additionally, there is a lack of comprehensive, up-to-date HZ economic data, with only six studies identified for the Philippines, Singapore, and Thailand. Conclusions Overall, there are limited data reporting incidence and prevalence of HZ in Southeast Asia at a national level. High rates of complications, symptoms, and abundance of case reports suggest substantial healthcare resource utilization for patients with HZ and highlight the need for further research in Southeast Asia assessing the societal impact.https://doi.org/10.1007/s40121-023-00822-0Herpes zosterIndonesiaMalaysiaPhilippinesShinglesSingapore |
| spellingShingle | Peter San Martin Kobkul Aunhachoke Maria Christina Filomena Batac Kris Lodrono-Lim Chanida Kwanthitinan Dicky Santoso Thanabalan Fonseka Minh Nguyen Adriana Guzman-Holst Systematic Literature Review of Herpes Zoster Disease Burden in Southeast Asia Infectious Diseases and Therapy Herpes zoster Indonesia Malaysia Philippines Shingles Singapore |
| title | Systematic Literature Review of Herpes Zoster Disease Burden in Southeast Asia |
| title_full | Systematic Literature Review of Herpes Zoster Disease Burden in Southeast Asia |
| title_fullStr | Systematic Literature Review of Herpes Zoster Disease Burden in Southeast Asia |
| title_full_unstemmed | Systematic Literature Review of Herpes Zoster Disease Burden in Southeast Asia |
| title_short | Systematic Literature Review of Herpes Zoster Disease Burden in Southeast Asia |
| title_sort | systematic literature review of herpes zoster disease burden in southeast asia |
| topic | Herpes zoster Indonesia Malaysia Philippines Shingles Singapore |
| url | https://doi.org/10.1007/s40121-023-00822-0 |
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