Serum BPI as a novel biomarker in asthma
Abstract Background Neutrophils, eosinophils and inflammatory cells contribute to asthmatic inflammation. The anti-bactericidal/permeability-increasing protein (BPI), produced by neutrophils, peripheral blood monocytes or epithelial cells, can neutralize lipopolysaccharide activity and enhance phago...
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| Format: | Article |
| Language: | English |
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BMC
2020-06-01
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| Series: | Allergy, Asthma & Clinical Immunology |
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| Online Access: | http://link.springer.com/article/10.1186/s13223-020-00450-0 |
| _version_ | 1818970778229538816 |
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| author | Chen Xingyuan Qiu Chen |
| author_facet | Chen Xingyuan Qiu Chen |
| author_sort | Chen Xingyuan |
| collection | DOAJ |
| description | Abstract Background Neutrophils, eosinophils and inflammatory cells contribute to asthmatic inflammation. The anti-bactericidal/permeability-increasing protein (BPI), produced by neutrophils, peripheral blood monocytes or epithelial cells, can neutralize lipopolysaccharide activity and enhance phagocytosis regulation function. This study aimed to assess the clinical significance of BPI in asthmatic patients. Methods We recruited 18 controlled asthma, 39 uncontrolled asthma and 35 healthy controls individuals. Clinical characteristics (age, gender, allergy history, body mass index (BMI) and smoking history), clinical indicators [whole blood count, forced expiratory volume in one second as percentage of predicted volume (FEV1% predicted), IgE level, high sensitivity C-reactive protein (hs-CRP) and fractional expiratory nitric oxide (FeNO)] and serum BPI levels were measured to compare among each group. We then evaluated the correlation between BPI, clinical characteristics and clinical indicators. Finally, linear regression analysis was performed to exclude the influence of other factors and to find the independent influencing factors of BPI. Results Our results showed that the serum BPI levels increased by twofold in the controlled asthma group (12.83 ± 6.04 ng/mL) and threefold in the uncontrolled asthma group (18.10 ± 13.48 ng/mL), compared to the healthy control group (6.00 ± 2.58 ng/mL) (p < 0.001). We further found that serum BPI levels were positively correlated with the hs-CRP (p = 0.002). There was no significant association among BPI, age, gender, BMI, allergy, blood eosinophils, blood neutrophils, IgE, FeNO or FEV1% predicted. Conclusion BPI levels were increased in asthma and positively correlated with hs-CRP. BPI as a potential asthma biomarker that still needs further research. |
| first_indexed | 2024-12-20T14:41:53Z |
| format | Article |
| id | doaj.art-f522f8bfc4b2491095e58dd1b5178bf9 |
| institution | Directory Open Access Journal |
| issn | 1710-1492 |
| language | English |
| last_indexed | 2024-12-20T14:41:53Z |
| publishDate | 2020-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Allergy, Asthma & Clinical Immunology |
| spelling | doaj.art-f522f8bfc4b2491095e58dd1b5178bf92022-12-21T19:37:15ZengBMCAllergy, Asthma & Clinical Immunology1710-14922020-06-011611710.1186/s13223-020-00450-0Serum BPI as a novel biomarker in asthmaChen Xingyuan0Qiu Chen1Department of Respiratory and Critical Care Medicine, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University), Shenzhen Institute of Respiratory DiseasesDepartment of Respiratory and Critical Care Medicine, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University), Shenzhen Institute of Respiratory DiseasesAbstract Background Neutrophils, eosinophils and inflammatory cells contribute to asthmatic inflammation. The anti-bactericidal/permeability-increasing protein (BPI), produced by neutrophils, peripheral blood monocytes or epithelial cells, can neutralize lipopolysaccharide activity and enhance phagocytosis regulation function. This study aimed to assess the clinical significance of BPI in asthmatic patients. Methods We recruited 18 controlled asthma, 39 uncontrolled asthma and 35 healthy controls individuals. Clinical characteristics (age, gender, allergy history, body mass index (BMI) and smoking history), clinical indicators [whole blood count, forced expiratory volume in one second as percentage of predicted volume (FEV1% predicted), IgE level, high sensitivity C-reactive protein (hs-CRP) and fractional expiratory nitric oxide (FeNO)] and serum BPI levels were measured to compare among each group. We then evaluated the correlation between BPI, clinical characteristics and clinical indicators. Finally, linear regression analysis was performed to exclude the influence of other factors and to find the independent influencing factors of BPI. Results Our results showed that the serum BPI levels increased by twofold in the controlled asthma group (12.83 ± 6.04 ng/mL) and threefold in the uncontrolled asthma group (18.10 ± 13.48 ng/mL), compared to the healthy control group (6.00 ± 2.58 ng/mL) (p < 0.001). We further found that serum BPI levels were positively correlated with the hs-CRP (p = 0.002). There was no significant association among BPI, age, gender, BMI, allergy, blood eosinophils, blood neutrophils, IgE, FeNO or FEV1% predicted. Conclusion BPI levels were increased in asthma and positively correlated with hs-CRP. BPI as a potential asthma biomarker that still needs further research.http://link.springer.com/article/10.1186/s13223-020-00450-0AsthmaBiomarkerBPI |
| spellingShingle | Chen Xingyuan Qiu Chen Serum BPI as a novel biomarker in asthma Allergy, Asthma & Clinical Immunology Asthma Biomarker BPI |
| title | Serum BPI as a novel biomarker in asthma |
| title_full | Serum BPI as a novel biomarker in asthma |
| title_fullStr | Serum BPI as a novel biomarker in asthma |
| title_full_unstemmed | Serum BPI as a novel biomarker in asthma |
| title_short | Serum BPI as a novel biomarker in asthma |
| title_sort | serum bpi as a novel biomarker in asthma |
| topic | Asthma Biomarker BPI |
| url | http://link.springer.com/article/10.1186/s13223-020-00450-0 |
| work_keys_str_mv | AT chenxingyuan serumbpiasanovelbiomarkerinasthma AT qiuchen serumbpiasanovelbiomarkerinasthma |