Evaluation of Serum IgA level in nontreated and treated oral squamous cell carcinoma patients
Introduction: Research in early cancer detection has led to discovery of many immunological tumor markers that contribute considerably to supplement the method of diagnosis. High serum immunoglobulin A (IgA) values in patients with cancer have been used as tumor markers. Aims and Objectives: To eval...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Journal of Indian Academy of Oral Medicine and Radiology |
| Subjects: | |
| Online Access: | http://www.jiaomr.in/article.asp?issn=0972-1363;year=2018;volume=30;issue=1;spage=10;epage=13;aulast=Mishra |
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| author | Richa Mishra Thimmarasa V Bhovi Prashant P Jaju Manas Gupta Kriti Shrivastava Ritu Mishra |
| author_facet | Richa Mishra Thimmarasa V Bhovi Prashant P Jaju Manas Gupta Kriti Shrivastava Ritu Mishra |
| author_sort | Richa Mishra |
| collection | DOAJ |
| description | Introduction: Research in early cancer detection has led to discovery of many immunological tumor markers that contribute considerably to supplement the method of diagnosis. High serum immunoglobulin A (IgA) values in patients with cancer have been used as tumor markers. Aims and Objectives: To evaluate and compare the serum IgA levels in nontreated, treated oral squamous cell carcinoma (SCC) patients, and control group. Materials and Methods: A total of 60 patients were included in the study. 20 biopsy confirmed oral SCC patients, who have received no medical treatment, 20 oral SCC patients treated with surgery and/or radiotherapy and 20 normal healthy individuals. Venous blood samples were collected from anterior cubital vein and were delivered to the biochemistry laboratory for the estimation of serum IgA level by nephelometry method. Statistical Analysis Used: Statistical method employed were the Pearson's Chi-square test and One-way analysis of variance (Welch) followed by Games-Howell post-hoc test. Results: We observed significant difference for serum IgA between study subjects in control, nontreated and treated oral SCC patients (P < 0.001). Serum IgA level in nontreated group was significantly higher than treated group and there was an approximately two-fold increase in serum IgA level in nontreated oral SCC patients when compared to that of the normal healthy individuals. Conclusion: Serum level of IgA might be employed as diagnostic and prognostic indicators in oral cancer. |
| first_indexed | 2024-12-16T17:16:37Z |
| format | Article |
| id | doaj.art-f5244dcf8bfc471ea8fb354f74a5c196 |
| institution | Directory Open Access Journal |
| issn | 0972-1363 |
| language | English |
| last_indexed | 2024-12-16T17:16:37Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Indian Academy of Oral Medicine and Radiology |
| spelling | doaj.art-f5244dcf8bfc471ea8fb354f74a5c1962022-12-21T22:23:17ZengWolters Kluwer Medknow PublicationsJournal of Indian Academy of Oral Medicine and Radiology0972-13632018-01-01301101310.4103/jiaomr.jiaomr_120_17Evaluation of Serum IgA level in nontreated and treated oral squamous cell carcinoma patientsRicha MishraThimmarasa V BhoviPrashant P JajuManas GuptaKriti ShrivastavaRitu MishraIntroduction: Research in early cancer detection has led to discovery of many immunological tumor markers that contribute considerably to supplement the method of diagnosis. High serum immunoglobulin A (IgA) values in patients with cancer have been used as tumor markers. Aims and Objectives: To evaluate and compare the serum IgA levels in nontreated, treated oral squamous cell carcinoma (SCC) patients, and control group. Materials and Methods: A total of 60 patients were included in the study. 20 biopsy confirmed oral SCC patients, who have received no medical treatment, 20 oral SCC patients treated with surgery and/or radiotherapy and 20 normal healthy individuals. Venous blood samples were collected from anterior cubital vein and were delivered to the biochemistry laboratory for the estimation of serum IgA level by nephelometry method. Statistical Analysis Used: Statistical method employed were the Pearson's Chi-square test and One-way analysis of variance (Welch) followed by Games-Howell post-hoc test. Results: We observed significant difference for serum IgA between study subjects in control, nontreated and treated oral SCC patients (P < 0.001). Serum IgA level in nontreated group was significantly higher than treated group and there was an approximately two-fold increase in serum IgA level in nontreated oral SCC patients when compared to that of the normal healthy individuals. Conclusion: Serum level of IgA might be employed as diagnostic and prognostic indicators in oral cancer.http://www.jiaomr.in/article.asp?issn=0972-1363;year=2018;volume=30;issue=1;spage=10;epage=13;aulast=MishraOral squamous cell carcinomaserum IgAserum immunoglobulins |
| spellingShingle | Richa Mishra Thimmarasa V Bhovi Prashant P Jaju Manas Gupta Kriti Shrivastava Ritu Mishra Evaluation of Serum IgA level in nontreated and treated oral squamous cell carcinoma patients Journal of Indian Academy of Oral Medicine and Radiology Oral squamous cell carcinoma serum IgA serum immunoglobulins |
| title | Evaluation of Serum IgA level in nontreated and treated oral squamous cell carcinoma patients |
| title_full | Evaluation of Serum IgA level in nontreated and treated oral squamous cell carcinoma patients |
| title_fullStr | Evaluation of Serum IgA level in nontreated and treated oral squamous cell carcinoma patients |
| title_full_unstemmed | Evaluation of Serum IgA level in nontreated and treated oral squamous cell carcinoma patients |
| title_short | Evaluation of Serum IgA level in nontreated and treated oral squamous cell carcinoma patients |
| title_sort | evaluation of serum iga level in nontreated and treated oral squamous cell carcinoma patients |
| topic | Oral squamous cell carcinoma serum IgA serum immunoglobulins |
| url | http://www.jiaomr.in/article.asp?issn=0972-1363;year=2018;volume=30;issue=1;spage=10;epage=13;aulast=Mishra |
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