Epigenetics underpinning the regulation of the CXC (ELR+) chemokines in non-small cell lung cancer.
BACKGROUND:Angiogenesis may play a role in the pathogenesis of Non-Small Cell Lung cancer (NSCLC). The CXC (ELR(+)) chemokine family are powerful promoters of the angiogenic response. METHODS:The expression of the CXC (ELR(+)) family members (CXCL1-3/GROα-γ, CXCL8/IL-8, CXCR1/2) was examined in a se...
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3029265?pdf=render |
| _version_ | 1818278020373282816 |
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| author | Anne-Marie Baird Steven G Gray Kenneth J O'Byrne |
| author_facet | Anne-Marie Baird Steven G Gray Kenneth J O'Byrne |
| author_sort | Anne-Marie Baird |
| collection | DOAJ |
| description | BACKGROUND:Angiogenesis may play a role in the pathogenesis of Non-Small Cell Lung cancer (NSCLC). The CXC (ELR(+)) chemokine family are powerful promoters of the angiogenic response. METHODS:The expression of the CXC (ELR(+)) family members (CXCL1-3/GROα-γ, CXCL8/IL-8, CXCR1/2) was examined in a series of resected fresh frozen NSCLC tumours. Additionally, the expression and epigenetic regulation of these chemokines was examined in normal bronchial epithelial and NSCLC cell lines. RESULTS:Overall, expression of the chemokine ligands (CXCL1, 2, 8) and their receptors (CXCR1/2) were down regulated in tumour samples compared with normal, with the exception of CXCL3. CXCL8 and CXCR1/2 were found to be epigenetically regulated by histone post-translational modifications. Recombinant CXCL8 did not stimulate cell growth in either a normal bronchial epithelial or a squamous carcinoma cell line (SKMES-1). However, an increase was observed at 72 hours post treatment in an adenocarcinoma cell line. CONCLUSIONS:CXC (ELR(+)) chemokines are dysregulated in NSCLC. The balance of these chemokines may be critical in the tumour microenvironment and requires further elucidation. It remains to be seen if epigenetic targeting of these pathways is a viable therapeutic option in lung cancer treatment. |
| first_indexed | 2024-12-12T23:10:48Z |
| format | Article |
| id | doaj.art-f52796ac24d04638b9cfc843db5d5060 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T23:10:48Z |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f52796ac24d04638b9cfc843db5d50602022-12-22T00:08:35ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0161e1459310.1371/journal.pone.0014593Epigenetics underpinning the regulation of the CXC (ELR+) chemokines in non-small cell lung cancer.Anne-Marie BairdSteven G GrayKenneth J O'ByrneBACKGROUND:Angiogenesis may play a role in the pathogenesis of Non-Small Cell Lung cancer (NSCLC). The CXC (ELR(+)) chemokine family are powerful promoters of the angiogenic response. METHODS:The expression of the CXC (ELR(+)) family members (CXCL1-3/GROα-γ, CXCL8/IL-8, CXCR1/2) was examined in a series of resected fresh frozen NSCLC tumours. Additionally, the expression and epigenetic regulation of these chemokines was examined in normal bronchial epithelial and NSCLC cell lines. RESULTS:Overall, expression of the chemokine ligands (CXCL1, 2, 8) and their receptors (CXCR1/2) were down regulated in tumour samples compared with normal, with the exception of CXCL3. CXCL8 and CXCR1/2 were found to be epigenetically regulated by histone post-translational modifications. Recombinant CXCL8 did not stimulate cell growth in either a normal bronchial epithelial or a squamous carcinoma cell line (SKMES-1). However, an increase was observed at 72 hours post treatment in an adenocarcinoma cell line. CONCLUSIONS:CXC (ELR(+)) chemokines are dysregulated in NSCLC. The balance of these chemokines may be critical in the tumour microenvironment and requires further elucidation. It remains to be seen if epigenetic targeting of these pathways is a viable therapeutic option in lung cancer treatment.http://europepmc.org/articles/PMC3029265?pdf=render |
| spellingShingle | Anne-Marie Baird Steven G Gray Kenneth J O'Byrne Epigenetics underpinning the regulation of the CXC (ELR+) chemokines in non-small cell lung cancer. PLoS ONE |
| title | Epigenetics underpinning the regulation of the CXC (ELR+) chemokines in non-small cell lung cancer. |
| title_full | Epigenetics underpinning the regulation of the CXC (ELR+) chemokines in non-small cell lung cancer. |
| title_fullStr | Epigenetics underpinning the regulation of the CXC (ELR+) chemokines in non-small cell lung cancer. |
| title_full_unstemmed | Epigenetics underpinning the regulation of the CXC (ELR+) chemokines in non-small cell lung cancer. |
| title_short | Epigenetics underpinning the regulation of the CXC (ELR+) chemokines in non-small cell lung cancer. |
| title_sort | epigenetics underpinning the regulation of the cxc elr chemokines in non small cell lung cancer |
| url | http://europepmc.org/articles/PMC3029265?pdf=render |
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