Insights into the Safety and Versatility of 4D Printed Intravesical Drug Delivery Systems
This paper focuses on recent advancements in the development of 4D printed drug delivery systems (DDSs) for the intravesical administration of drugs. By coupling the effectiveness of local treatments with major compliance and long-lasting performance, they would represent a promising innovation for...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/15/3/757 |
| _version_ | 1797609607900692480 |
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| author | Marco Uboldi Cristiana Perrotta Claudia Moscheni Silvia Zecchini Alessandra Napoli Chiara Castiglioni Andrea Gazzaniga Alice Melocchi Lucia Zema |
| author_facet | Marco Uboldi Cristiana Perrotta Claudia Moscheni Silvia Zecchini Alessandra Napoli Chiara Castiglioni Andrea Gazzaniga Alice Melocchi Lucia Zema |
| author_sort | Marco Uboldi |
| collection | DOAJ |
| description | This paper focuses on recent advancements in the development of 4D printed drug delivery systems (DDSs) for the intravesical administration of drugs. By coupling the effectiveness of local treatments with major compliance and long-lasting performance, they would represent a promising innovation for the current treatment of bladder pathologies. Being based on a shape-memory pharmaceutical-grade polyvinyl alcohol (PVA), these DDSs are manufactured in a bulky shape, can be programmed to take on a collapsed one suitable for insertion into a catheter and re-expand inside the target organ, following exposure to biological fluids at body temperature, while releasing their content. The biocompatibility of prototypes made of PVAs of different molecular weight, either uncoated or coated with Eudragit<sup>®</sup>-based formulations, was assessed by excluding relevant in vitro toxicity and inflammatory response using bladder cancer and human monocytic cell lines. Moreover, the feasibility of a novel configuration was preliminarily investigated, targeting the development of prototypes provided with inner reservoirs to be filled with different drug-containing formulations. Samples entailing two cavities, filled during the printing process, were successfully fabricated and showed, in simulated urine at body temperature, potential for controlled release, while maintaining the ability to recover about 70% of their original shape within 3 min. |
| first_indexed | 2024-03-11T06:02:48Z |
| format | Article |
| id | doaj.art-f5298b4ddb0e479fba7da6918585ea08 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T06:02:48Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-f5298b4ddb0e479fba7da6918585ea082023-11-17T13:13:57ZengMDPI AGPharmaceutics1999-49232023-02-0115375710.3390/pharmaceutics15030757Insights into the Safety and Versatility of 4D Printed Intravesical Drug Delivery SystemsMarco Uboldi0Cristiana Perrotta1Claudia Moscheni2Silvia Zecchini3Alessandra Napoli4Chiara Castiglioni5Andrea Gazzaniga6Alice Melocchi7Lucia Zema8Sezione di Tecnologia e Legislazione Farmaceutiche “Maria Edvige Sangalli”, Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, via Giuseppe Colombo 71, 20133 Milano, ItalyDipartimento di Scienze Biomediche e Cliniche, Università degli Studi di Milano, via Giovanni Battista Grassi 74, 20157 Milano, ItalyDipartimento di Scienze Biomediche e Cliniche, Università degli Studi di Milano, via Giovanni Battista Grassi 74, 20157 Milano, ItalyDipartimento di Scienze Biomediche e Cliniche, Università degli Studi di Milano, via Giovanni Battista Grassi 74, 20157 Milano, ItalyDipartimento di Scienze Biomediche e Cliniche, Università degli Studi di Milano, via Giovanni Battista Grassi 74, 20157 Milano, ItalyDipartimento di Chimica, Materiali e Ingegneria Chimica “Giulio Natta”, Politecnico di Milano, piazza Leonardo da Vinci 32, 20133 Milan, ItalySezione di Tecnologia e Legislazione Farmaceutiche “Maria Edvige Sangalli”, Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, via Giuseppe Colombo 71, 20133 Milano, ItalySezione di Tecnologia e Legislazione Farmaceutiche “Maria Edvige Sangalli”, Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, via Giuseppe Colombo 71, 20133 Milano, ItalySezione di Tecnologia e Legislazione Farmaceutiche “Maria Edvige Sangalli”, Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, via Giuseppe Colombo 71, 20133 Milano, ItalyThis paper focuses on recent advancements in the development of 4D printed drug delivery systems (DDSs) for the intravesical administration of drugs. By coupling the effectiveness of local treatments with major compliance and long-lasting performance, they would represent a promising innovation for the current treatment of bladder pathologies. Being based on a shape-memory pharmaceutical-grade polyvinyl alcohol (PVA), these DDSs are manufactured in a bulky shape, can be programmed to take on a collapsed one suitable for insertion into a catheter and re-expand inside the target organ, following exposure to biological fluids at body temperature, while releasing their content. The biocompatibility of prototypes made of PVAs of different molecular weight, either uncoated or coated with Eudragit<sup>®</sup>-based formulations, was assessed by excluding relevant in vitro toxicity and inflammatory response using bladder cancer and human monocytic cell lines. Moreover, the feasibility of a novel configuration was preliminarily investigated, targeting the development of prototypes provided with inner reservoirs to be filled with different drug-containing formulations. Samples entailing two cavities, filled during the printing process, were successfully fabricated and showed, in simulated urine at body temperature, potential for controlled release, while maintaining the ability to recover about 70% of their original shape within 3 min.https://www.mdpi.com/1999-4923/15/3/7573D printingcytotoxicitycontrolled releasefused deposition modelinglocal deliveryretentive systems |
| spellingShingle | Marco Uboldi Cristiana Perrotta Claudia Moscheni Silvia Zecchini Alessandra Napoli Chiara Castiglioni Andrea Gazzaniga Alice Melocchi Lucia Zema Insights into the Safety and Versatility of 4D Printed Intravesical Drug Delivery Systems Pharmaceutics 3D printing cytotoxicity controlled release fused deposition modeling local delivery retentive systems |
| title | Insights into the Safety and Versatility of 4D Printed Intravesical Drug Delivery Systems |
| title_full | Insights into the Safety and Versatility of 4D Printed Intravesical Drug Delivery Systems |
| title_fullStr | Insights into the Safety and Versatility of 4D Printed Intravesical Drug Delivery Systems |
| title_full_unstemmed | Insights into the Safety and Versatility of 4D Printed Intravesical Drug Delivery Systems |
| title_short | Insights into the Safety and Versatility of 4D Printed Intravesical Drug Delivery Systems |
| title_sort | insights into the safety and versatility of 4d printed intravesical drug delivery systems |
| topic | 3D printing cytotoxicity controlled release fused deposition modeling local delivery retentive systems |
| url | https://www.mdpi.com/1999-4923/15/3/757 |
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