Effect of long-term cannabidiol on learning and anxiety in a female Alzheimer’s disease mouse model
Cannabidiol is a promising potential therapeutic for neurodegenerative diseases, including Alzheimer’s disease (AD). Our laboratory has shown that oral CBD treatment prevents cognitive impairment in a male genetic mouse model of AD, the amyloid precursor protein 1 x presenilin 1 hemizygous (APPxPS1)...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.931384/full |
| _version_ | 1818033254246121472 |
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| author | Rose Chesworth David Cheng Chloe Staub Tim Karl Tim Karl |
| author_facet | Rose Chesworth David Cheng Chloe Staub Tim Karl Tim Karl |
| author_sort | Rose Chesworth |
| collection | DOAJ |
| description | Cannabidiol is a promising potential therapeutic for neurodegenerative diseases, including Alzheimer’s disease (AD). Our laboratory has shown that oral CBD treatment prevents cognitive impairment in a male genetic mouse model of AD, the amyloid precursor protein 1 x presenilin 1 hemizygous (APPxPS1) mouse. However, as sex differences are evident in clinical populations and in AD mouse models, we tested the preventive potential of CBD therapy in female APPxPS1 mice. In this study, 2.5-month-old female wildtype-like (WT) and APPxPS1 mice were fed 20 mg/kg CBD or a vehicle via gel pellets daily for 8 months and tested at 10.5 months in behavioural paradigms relevant to cognition (fear conditioning, FC; cheeseboard, CB; and novel object recognition test, NORT) and anxiety-like behaviours (elevated plus maze, EPM). In the CB, CBD reduced latencies to find a food reward in APPxPS1 mice, compared to vehicle-treated APPxPS1 controls, and this treatment effect was not evident in WT mice. In addition, CBD also increased speed early in the acquisition of the CB task in APPxPS1 mice. In the EPM, CBD increased locomotion in APPxPS1 mice but not in WT mice, with no effects of CBD on anxiety-like behaviour. CBD had limited effects on the expression of fear memory. These results indicate preventive CBD treatment can have a moderate spatial learning-enhancing effect in a female amyloid-β-based AD mouse model. This suggests CBD may have some preventive therapeutic potential in female familial AD patients. |
| first_indexed | 2024-12-10T06:20:20Z |
| format | Article |
| id | doaj.art-f52c77a3855c4c079788a7b578da26b0 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-10T06:20:20Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-f52c77a3855c4c079788a7b578da26b02022-12-22T01:59:22ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-09-011310.3389/fphar.2022.931384931384Effect of long-term cannabidiol on learning and anxiety in a female Alzheimer’s disease mouse modelRose Chesworth0David Cheng1Chloe Staub2Tim Karl3Tim Karl4School of Medicine, Western Sydney University, Campbelltown, NSW, AustraliaNeuroscience Research Australia, Randwick, NSW, AustraliaSchool of Medicine, Western Sydney University, Campbelltown, NSW, AustraliaSchool of Medicine, Western Sydney University, Campbelltown, NSW, AustraliaNeuroscience Research Australia, Randwick, NSW, AustraliaCannabidiol is a promising potential therapeutic for neurodegenerative diseases, including Alzheimer’s disease (AD). Our laboratory has shown that oral CBD treatment prevents cognitive impairment in a male genetic mouse model of AD, the amyloid precursor protein 1 x presenilin 1 hemizygous (APPxPS1) mouse. However, as sex differences are evident in clinical populations and in AD mouse models, we tested the preventive potential of CBD therapy in female APPxPS1 mice. In this study, 2.5-month-old female wildtype-like (WT) and APPxPS1 mice were fed 20 mg/kg CBD or a vehicle via gel pellets daily for 8 months and tested at 10.5 months in behavioural paradigms relevant to cognition (fear conditioning, FC; cheeseboard, CB; and novel object recognition test, NORT) and anxiety-like behaviours (elevated plus maze, EPM). In the CB, CBD reduced latencies to find a food reward in APPxPS1 mice, compared to vehicle-treated APPxPS1 controls, and this treatment effect was not evident in WT mice. In addition, CBD also increased speed early in the acquisition of the CB task in APPxPS1 mice. In the EPM, CBD increased locomotion in APPxPS1 mice but not in WT mice, with no effects of CBD on anxiety-like behaviour. CBD had limited effects on the expression of fear memory. These results indicate preventive CBD treatment can have a moderate spatial learning-enhancing effect in a female amyloid-β-based AD mouse model. This suggests CBD may have some preventive therapeutic potential in female familial AD patients.https://www.frontiersin.org/articles/10.3389/fphar.2022.931384/fullAlzheimer’s diseasebehaviourcannabidiol (CBD)spatial memoryfemaleamyloid precursor protein |
| spellingShingle | Rose Chesworth David Cheng Chloe Staub Tim Karl Tim Karl Effect of long-term cannabidiol on learning and anxiety in a female Alzheimer’s disease mouse model Frontiers in Pharmacology Alzheimer’s disease behaviour cannabidiol (CBD) spatial memory female amyloid precursor protein |
| title | Effect of long-term cannabidiol on learning and anxiety in a female Alzheimer’s disease mouse model |
| title_full | Effect of long-term cannabidiol on learning and anxiety in a female Alzheimer’s disease mouse model |
| title_fullStr | Effect of long-term cannabidiol on learning and anxiety in a female Alzheimer’s disease mouse model |
| title_full_unstemmed | Effect of long-term cannabidiol on learning and anxiety in a female Alzheimer’s disease mouse model |
| title_short | Effect of long-term cannabidiol on learning and anxiety in a female Alzheimer’s disease mouse model |
| title_sort | effect of long term cannabidiol on learning and anxiety in a female alzheimer s disease mouse model |
| topic | Alzheimer’s disease behaviour cannabidiol (CBD) spatial memory female amyloid precursor protein |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.931384/full |
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