Meningioma genomics: a therapeutic challenge for clinicians
Meningiomas are amongst the most commonly encountered intracranial tumors. The majority of these tumors arise intracranially, and the remaining incidents occur along the spinal cord. Meningiomas tend to grow gradually, with many tumors arising in inaccessible locations. Such sporadic behavior pos...
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| Format: | Article |
| Language: | English |
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IMR Press
2021-06-01
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| Series: | Journal of Integrative Neuroscience |
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| Online Access: | https://jin.imrpress.com/fileup/1757-448X/PDF/1625014743304-763030558.pdf |
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| author | Charbel Moussalem Elie Massaad Georges B. Minassian Louna Ftouni Shadi Bsat Mohamad N. El Houshiemy Safwan Alomari Rana Sarieddine Firas Kobeissy Ibrahim Omeis |
| author_facet | Charbel Moussalem Elie Massaad Georges B. Minassian Louna Ftouni Shadi Bsat Mohamad N. El Houshiemy Safwan Alomari Rana Sarieddine Firas Kobeissy Ibrahim Omeis |
| author_sort | Charbel Moussalem |
| collection | DOAJ |
| description | Meningiomas are amongst the most commonly encountered intracranial tumors. The
majority of these tumors arise intracranially, and the remaining incidents occur
along the spinal cord. Meningiomas tend to grow gradually, with many tumors
arising in inaccessible locations. Such sporadic behavior poses a therapeutic
challenge to clinicians, causing incomplete tumor resections that often lead to
recurrence. Therefore, ongoing research seeks to find alternative systematic
treatments for meningiomas, with gene-based therapeutics of high interest.
Subsequently, genetic studies characterized frequent somatic mutations in
NF2, TRAF7, KLF4, AKT1, SMO, and
PIK3CA. These genes are communally exhibited in 80% of sporadic
meningiomas. In addition, other genes such as the DUSP family, the NR4
family, CMKOR, and FOSL2, have been identified as key players
in spinal meningiomas. In this perspective, we aim to investigate current
genetic-based studies, with the ongoing research mainly focused on the above
NF2, TRAF7, KLF4, AKT1, SMO, and
PIK3CA genes and their involved pathways. In addition, this perspective can serve as a potential cornerstone for future genetic analyses of
meningioma cases. |
| first_indexed | 2024-04-13T07:12:59Z |
| format | Article |
| id | doaj.art-f52f63b0deaf4eb69b18eea714436d39 |
| institution | Directory Open Access Journal |
| issn | 1757-448X |
| language | English |
| last_indexed | 2024-04-13T07:12:59Z |
| publishDate | 2021-06-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Journal of Integrative Neuroscience |
| spelling | doaj.art-f52f63b0deaf4eb69b18eea714436d392022-12-22T02:56:50ZengIMR PressJournal of Integrative Neuroscience1757-448X2021-06-0120246346910.31083/j.jin20020491625014743304-763030558Meningioma genomics: a therapeutic challenge for cliniciansCharbel Moussalem0Elie Massaad1Georges B. Minassian2Louna Ftouni3Shadi Bsat4Mohamad N. El Houshiemy5Safwan Alomari6Rana Sarieddine7Firas Kobeissy8Ibrahim Omeis9Division of Neurosurgery, Department of Surgery, American University of Beirut Medical Center, 11-0236 Beirut, LebanonFaculty of Medicine, American University of Beirut Medical Center, 11-0236 Beirut, LebanonDivision of Neurosurgery, Department of Surgery, American University of Beirut Medical Center, 11-0236 Beirut, LebanonFaculty of Medicine, Beirut Arab University, 11072809 Beirut, LebanonDivision of Neurosurgery, Department of Surgery, American University of Beirut Medical Center, 11-0236 Beirut, LebanonDivision of Neurosurgery, Department of Surgery, American University of Beirut Medical Center, 11-0236 Beirut, LebanonDivision of Neurosurgery, Department of Surgery, American University of Beirut Medical Center, 11-0236 Beirut, LebanonDivision of Neurosurgery, Department of Surgery, American University of Beirut Medical Center, 11-0236 Beirut, LebanonDepartment of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, 11-0236 Beirut, LebanonDivision of Neurosurgery, Department of Surgery, American University of Beirut Medical Center, 11-0236 Beirut, LebanonMeningiomas are amongst the most commonly encountered intracranial tumors. The majority of these tumors arise intracranially, and the remaining incidents occur along the spinal cord. Meningiomas tend to grow gradually, with many tumors arising in inaccessible locations. Such sporadic behavior poses a therapeutic challenge to clinicians, causing incomplete tumor resections that often lead to recurrence. Therefore, ongoing research seeks to find alternative systematic treatments for meningiomas, with gene-based therapeutics of high interest. Subsequently, genetic studies characterized frequent somatic mutations in NF2, TRAF7, KLF4, AKT1, SMO, and PIK3CA. These genes are communally exhibited in 80% of sporadic meningiomas. In addition, other genes such as the DUSP family, the NR4 family, CMKOR, and FOSL2, have been identified as key players in spinal meningiomas. In this perspective, we aim to investigate current genetic-based studies, with the ongoing research mainly focused on the above NF2, TRAF7, KLF4, AKT1, SMO, and PIK3CA genes and their involved pathways. In addition, this perspective can serve as a potential cornerstone for future genetic analyses of meningioma cases.https://jin.imrpress.com/fileup/1757-448X/PDF/1625014743304-763030558.pdfgeneticscranial meningiomaspinal meningiomasomatic mutationsgene-targeting therapyneurology |
| spellingShingle | Charbel Moussalem Elie Massaad Georges B. Minassian Louna Ftouni Shadi Bsat Mohamad N. El Houshiemy Safwan Alomari Rana Sarieddine Firas Kobeissy Ibrahim Omeis Meningioma genomics: a therapeutic challenge for clinicians Journal of Integrative Neuroscience genetics cranial meningioma spinal meningioma somatic mutations gene-targeting therapy neurology |
| title | Meningioma genomics: a therapeutic challenge for clinicians |
| title_full | Meningioma genomics: a therapeutic challenge for clinicians |
| title_fullStr | Meningioma genomics: a therapeutic challenge for clinicians |
| title_full_unstemmed | Meningioma genomics: a therapeutic challenge for clinicians |
| title_short | Meningioma genomics: a therapeutic challenge for clinicians |
| title_sort | meningioma genomics a therapeutic challenge for clinicians |
| topic | genetics cranial meningioma spinal meningioma somatic mutations gene-targeting therapy neurology |
| url | https://jin.imrpress.com/fileup/1757-448X/PDF/1625014743304-763030558.pdf |
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