The Correlation between Serum Inositol 1,4,5 Triphosphate Level and Primary Hypothyroidism
Background: Most primary hypothyroidism patients also experience inefficiency and irregularity. It is possible to understand the significance of myo-inositol in treating the thyroid gland by relating it to the synthesis of thyroid hormones. Study aimed to estimate serum of inositol 1,4,5-triphospha...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
University of Baghdad/ Al-Kindy College of Medicine
2022-12-01
|
| Series: | مجله كليه طب الكندي |
| Subjects: | |
| Online Access: | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/862 |
| _version_ | 1797974164907229184 |
|---|---|
| author | Akram Sabah Matshar Maysaa Jalal Majeed Mohamed Sadoon Mohson |
| author_facet | Akram Sabah Matshar Maysaa Jalal Majeed Mohamed Sadoon Mohson |
| author_sort | Akram Sabah Matshar |
| collection | DOAJ |
| description |
Background: Most primary hypothyroidism patients also experience inefficiency and irregularity. It is possible to understand the significance of myo-inositol in treating the thyroid gland by relating it to the synthesis of thyroid hormones. Study aimed to estimate serum of inositol 1,4,5-triphosphate (IP3) in primary hypothyroidism disorder and through that level it can shed light on whether it is accused of inactivity of the thyroid gland and at the same time open the doors for the use as a treatment.
Subject and Methods: The study was taken from the analytical cross-sectional design.120 subjects were divided into three groups, the first group included 40 healthy subjects, the second group included 25 patients with subclinical hypothyroidism, and the last group had 55 patients with primary hypothyroidism. with the subjects chosen from a teaching laboratory in the medical city. thyroid hormones and serum TSH was determined using Enzyme Immunoassay by Tosoh instrument assay, while serum inositol 1,4,5-triphosphate (IP3) using (ELISA) system.
Results: primary hypothyroidism patients showed a significant (p≤0.05) decrease level of serum IP3 when compared with healthy subjects. There is significant positive correlation with serum inositol 1,4,5 triphosphate (IP3) and each triiodothyronine S.T3 (r = 0.581, p ≤0.05), thyroxine S.T4 (r = 0.597, p ≤0.05), and significant negative correlation thyroid-stimulating hormone S.TSH (r=-0.820, p≤0.05), in primary hypothyroidism Patients.
Conclusions: inositol 1,4,5 triphosphate (IP3) deficiency in primary hypothyroidism disorder may be a cause of it happening, at the same time may be useful in its treatment even if it was not studied adequately in the study, but through its effect on a thyroid hormone.
|
| first_indexed | 2024-04-11T04:15:44Z |
| format | Article |
| id | doaj.art-f53052caa6214e719a92c07bd3a34426 |
| institution | Directory Open Access Journal |
| issn | 1810-9543 2521-4365 |
| language | English |
| last_indexed | 2024-04-11T04:15:44Z |
| publishDate | 2022-12-01 |
| publisher | University of Baghdad/ Al-Kindy College of Medicine |
| record_format | Article |
| series | مجله كليه طب الكندي |
| spelling | doaj.art-f53052caa6214e719a92c07bd3a344262022-12-31T19:40:53ZengUniversity of Baghdad/ Al-Kindy College of Medicineمجله كليه طب الكندي1810-95432521-43652022-12-0118310.47723/kcmj.v18i3.862The Correlation between Serum Inositol 1,4,5 Triphosphate Level and Primary Hypothyroidism Akram Sabah Matshar0Maysaa Jalal Majeed1Mohamed Sadoon Mohson2Department of Chemistry, College of Medicine, University of Baghdad. Baghdad, IraqDepartment of Chemistry, College of Medicine, University of Baghdad. Baghdad, IraqBaghdad Centre for Therapy Radiation and Nuclear Medicine, Medical City Complex, Baghdad, Iraq Background: Most primary hypothyroidism patients also experience inefficiency and irregularity. It is possible to understand the significance of myo-inositol in treating the thyroid gland by relating it to the synthesis of thyroid hormones. Study aimed to estimate serum of inositol 1,4,5-triphosphate (IP3) in primary hypothyroidism disorder and through that level it can shed light on whether it is accused of inactivity of the thyroid gland and at the same time open the doors for the use as a treatment. Subject and Methods: The study was taken from the analytical cross-sectional design.120 subjects were divided into three groups, the first group included 40 healthy subjects, the second group included 25 patients with subclinical hypothyroidism, and the last group had 55 patients with primary hypothyroidism. with the subjects chosen from a teaching laboratory in the medical city. thyroid hormones and serum TSH was determined using Enzyme Immunoassay by Tosoh instrument assay, while serum inositol 1,4,5-triphosphate (IP3) using (ELISA) system. Results: primary hypothyroidism patients showed a significant (p≤0.05) decrease level of serum IP3 when compared with healthy subjects. There is significant positive correlation with serum inositol 1,4,5 triphosphate (IP3) and each triiodothyronine S.T3 (r = 0.581, p ≤0.05), thyroxine S.T4 (r = 0.597, p ≤0.05), and significant negative correlation thyroid-stimulating hormone S.TSH (r=-0.820, p≤0.05), in primary hypothyroidism Patients. Conclusions: inositol 1,4,5 triphosphate (IP3) deficiency in primary hypothyroidism disorder may be a cause of it happening, at the same time may be useful in its treatment even if it was not studied adequately in the study, but through its effect on a thyroid hormone. https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/862hypothyroidismIP3: inositol 1,4,5-trisphosphateTSH: thyroid-stimulating hormonesubclinical hypothyroidism |
| spellingShingle | Akram Sabah Matshar Maysaa Jalal Majeed Mohamed Sadoon Mohson The Correlation between Serum Inositol 1,4,5 Triphosphate Level and Primary Hypothyroidism مجله كليه طب الكندي hypothyroidism IP3: inositol 1,4,5-trisphosphate TSH: thyroid-stimulating hormone subclinical hypothyroidism |
| title | The Correlation between Serum Inositol 1,4,5 Triphosphate Level and Primary Hypothyroidism |
| title_full | The Correlation between Serum Inositol 1,4,5 Triphosphate Level and Primary Hypothyroidism |
| title_fullStr | The Correlation between Serum Inositol 1,4,5 Triphosphate Level and Primary Hypothyroidism |
| title_full_unstemmed | The Correlation between Serum Inositol 1,4,5 Triphosphate Level and Primary Hypothyroidism |
| title_short | The Correlation between Serum Inositol 1,4,5 Triphosphate Level and Primary Hypothyroidism |
| title_sort | correlation between serum inositol 1 4 5 triphosphate level and primary hypothyroidism |
| topic | hypothyroidism IP3: inositol 1,4,5-trisphosphate TSH: thyroid-stimulating hormone subclinical hypothyroidism |
| url | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/862 |
| work_keys_str_mv | AT akramsabahmatshar thecorrelationbetweenseruminositol145triphosphatelevelandprimaryhypothyroidism AT maysaajalalmajeed thecorrelationbetweenseruminositol145triphosphatelevelandprimaryhypothyroidism AT mohamedsadoonmohson thecorrelationbetweenseruminositol145triphosphatelevelandprimaryhypothyroidism AT akramsabahmatshar correlationbetweenseruminositol145triphosphatelevelandprimaryhypothyroidism AT maysaajalalmajeed correlationbetweenseruminositol145triphosphatelevelandprimaryhypothyroidism AT mohamedsadoonmohson correlationbetweenseruminositol145triphosphatelevelandprimaryhypothyroidism |