LncRNA NEAT1 in Paraspeckles: A Structural Scaffold for Cellular DNA Damage Response Systems?
Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA (lncRNA) reported to be frequently deregulated in various types of cancers and neurodegenerative processes. NEAT1 is an indispensable structural component of paraspeckles (PSs), which are dynamic and membraneless nuclear bodi...
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| Format: | Article |
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MDPI AG
2020-07-01
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| Series: | Non-Coding RNA |
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| Online Access: | https://www.mdpi.com/2311-553X/6/3/26 |
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| author | Elisa Taiana Domenica Ronchetti Katia Todoerti Lucia Nobili Pierfrancesco Tassone Nicola Amodio Antonino Neri |
| author_facet | Elisa Taiana Domenica Ronchetti Katia Todoerti Lucia Nobili Pierfrancesco Tassone Nicola Amodio Antonino Neri |
| author_sort | Elisa Taiana |
| collection | DOAJ |
| description | Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA (lncRNA) reported to be frequently deregulated in various types of cancers and neurodegenerative processes. NEAT1 is an indispensable structural component of paraspeckles (PSs), which are dynamic and membraneless nuclear bodies that affect different cellular functions, including stress response. Furthermore, increasing evidence supports the crucial role of NEAT1 and essential structural proteins of PSs (PSPs) in the regulation of the DNA damage repair (DDR) system. This review aims to provide an overview of the current knowledge on the involvement of NEAT1 and PSPs in DDR, which might strengthen the rationale underlying future NEAT1-based therapeutic options in tumor and neurodegenerative diseases. |
| first_indexed | 2024-03-10T18:46:00Z |
| format | Article |
| id | doaj.art-f5312f7331ea47fdbf77693253defc54 |
| institution | Directory Open Access Journal |
| issn | 2311-553X |
| language | English |
| last_indexed | 2024-03-10T18:46:00Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Non-Coding RNA |
| spelling | doaj.art-f5312f7331ea47fdbf77693253defc542023-11-20T05:31:44ZengMDPI AGNon-Coding RNA2311-553X2020-07-01632610.3390/ncrna6030026LncRNA NEAT1 in Paraspeckles: A Structural Scaffold for Cellular DNA Damage Response Systems?Elisa Taiana0Domenica Ronchetti1Katia Todoerti2Lucia Nobili3Pierfrancesco Tassone4Nicola Amodio5Antonino Neri6Department of Oncology and Hemato-oncology, University of Milan, 20122 Milan, ItalyDepartment of Oncology and Hemato-oncology, University of Milan, 20122 Milan, ItalyHematology, Fondazione Cà Granda IRCCS Policlinico, 20122 Milan, ItalyDepartment of Oncology and Hemato-oncology, University of Milan, 20122 Milan, ItalyDepartment of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, 88100 Catanzaro, ItalyDepartment of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, 88100 Catanzaro, ItalyDepartment of Oncology and Hemato-oncology, University of Milan, 20122 Milan, ItalyNuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA (lncRNA) reported to be frequently deregulated in various types of cancers and neurodegenerative processes. NEAT1 is an indispensable structural component of paraspeckles (PSs), which are dynamic and membraneless nuclear bodies that affect different cellular functions, including stress response. Furthermore, increasing evidence supports the crucial role of NEAT1 and essential structural proteins of PSs (PSPs) in the regulation of the DNA damage repair (DDR) system. This review aims to provide an overview of the current knowledge on the involvement of NEAT1 and PSPs in DDR, which might strengthen the rationale underlying future NEAT1-based therapeutic options in tumor and neurodegenerative diseases.https://www.mdpi.com/2311-553X/6/3/26lncRNANEAT1paraspeckleDNA damage repaircancerneurodegenerative disease |
| spellingShingle | Elisa Taiana Domenica Ronchetti Katia Todoerti Lucia Nobili Pierfrancesco Tassone Nicola Amodio Antonino Neri LncRNA NEAT1 in Paraspeckles: A Structural Scaffold for Cellular DNA Damage Response Systems? Non-Coding RNA lncRNA NEAT1 paraspeckle DNA damage repair cancer neurodegenerative disease |
| title | LncRNA NEAT1 in Paraspeckles: A Structural Scaffold for Cellular DNA Damage Response Systems? |
| title_full | LncRNA NEAT1 in Paraspeckles: A Structural Scaffold for Cellular DNA Damage Response Systems? |
| title_fullStr | LncRNA NEAT1 in Paraspeckles: A Structural Scaffold for Cellular DNA Damage Response Systems? |
| title_full_unstemmed | LncRNA NEAT1 in Paraspeckles: A Structural Scaffold for Cellular DNA Damage Response Systems? |
| title_short | LncRNA NEAT1 in Paraspeckles: A Structural Scaffold for Cellular DNA Damage Response Systems? |
| title_sort | lncrna neat1 in paraspeckles a structural scaffold for cellular dna damage response systems |
| topic | lncRNA NEAT1 paraspeckle DNA damage repair cancer neurodegenerative disease |
| url | https://www.mdpi.com/2311-553X/6/3/26 |
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