Assessing the expression of two post-transcriptional BDNF regulators, TTP and miR-16 in the peripheral blood of patients with Schizophrenia
Abstract Schizophrenia (SCZ) is a severe mental disorder with an unknown pathophysiology. Brain-Derived Neurotrophic Factor (BDNF) is a neurotrophin that has been associated with synapse plasticity, learning, and memory, as well as neurodevelopment and neuroprotection. The importance of neurodevelop...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | BMC Psychiatry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12888-022-04442-9 |
| _version_ | 1811204009790275584 |
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| author | Mohammad Reza Asadi Jalal Gharesouran Hani Sabaie Marziyeh Sadat Moslehian Hossein Dehghani Shahram Arsang-Jang Mohammad Taheri Deniz Mortazavi Bashdar Mahmud Hussen Arezou Sayad Maryam Rezazadeh |
| author_facet | Mohammad Reza Asadi Jalal Gharesouran Hani Sabaie Marziyeh Sadat Moslehian Hossein Dehghani Shahram Arsang-Jang Mohammad Taheri Deniz Mortazavi Bashdar Mahmud Hussen Arezou Sayad Maryam Rezazadeh |
| author_sort | Mohammad Reza Asadi |
| collection | DOAJ |
| description | Abstract Schizophrenia (SCZ) is a severe mental disorder with an unknown pathophysiology. Brain-Derived Neurotrophic Factor (BDNF) is a neurotrophin that has been associated with synapse plasticity, learning, and memory, as well as neurodevelopment and neuroprotection. The importance of neurodevelopmental and neurotoxicity-related components in the pathophysiology of SCZ has been highlighted in research on the neurobiology of this disease. The purpose of this research is to investigate the significant expression of two variables, tristetraprolin (TTP) and miR-16, which are known to be regulators of BDNF expression. Fifty Iranian Azeri SCZ patients were enrolled, and fifty healthy volunteers were age- and gender-matched as controls. A quantitative polymerase chain reaction measured the expression levels of the TTP and miR-16 in the peripheral blood (PB) of SCZ patients and healthy people. TTP expression levels in patients were higher than in controls, regardless of gender or age (posterior beta = 1.532, adjusted P-value = 0.012). TTP and miR-16 expression levels were found to be significantly correlated in both SCZ patients and healthy controls (r = 0.701, P < 0.001 and r = 0.777, P < 0.001, respectively). Due to the increased expression of TTP in SCZ and the existence of a significant correlation between TTP and miR-16, which helps to act on target mRNAs with AU-rich elements, this mechanism can be considered an influencing factor in SCZ. |
| first_indexed | 2024-04-12T03:04:32Z |
| format | Article |
| id | doaj.art-f5325188f883499982c7409bdf03f994 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-04-12T03:04:32Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-f5325188f883499982c7409bdf03f9942022-12-22T03:50:33ZengBMCBMC Psychiatry1471-244X2022-12-0122111010.1186/s12888-022-04442-9Assessing the expression of two post-transcriptional BDNF regulators, TTP and miR-16 in the peripheral blood of patients with SchizophreniaMohammad Reza Asadi0Jalal Gharesouran1Hani Sabaie2Marziyeh Sadat Moslehian3Hossein Dehghani4Shahram Arsang-Jang5Mohammad Taheri6Deniz Mortazavi7Bashdar Mahmud Hussen8Arezou Sayad9Maryam Rezazadeh10Student Research Committee, Tabriz University of Medical SciencesDepartment of Medical Genetics, Faculty of Medicine, Tabriz University of Medical SciencesStudent Research Committee, Tabriz University of Medical SciencesStudent Research Committee, Tabriz University of Medical SciencesDepartment of Molecular Medicine, School of Medicine, Birjand University of Medical SciencesCancer Gene therapy Research Center, Zanjan University of Medical ScienceMen’s Health and Reproductive Health Research Center, Shahid Beheshti University of Medical SciencesDepartment of Genetics and Molecular Biology, School of Medicine, Isfahan university of medical sciencesDepartment of Pharmacognosy, College of Pharmacy, Hawler Medical UniversityDepartment of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical SciencesDepartment of Medical Genetics, Faculty of Medicine, Tabriz University of Medical SciencesAbstract Schizophrenia (SCZ) is a severe mental disorder with an unknown pathophysiology. Brain-Derived Neurotrophic Factor (BDNF) is a neurotrophin that has been associated with synapse plasticity, learning, and memory, as well as neurodevelopment and neuroprotection. The importance of neurodevelopmental and neurotoxicity-related components in the pathophysiology of SCZ has been highlighted in research on the neurobiology of this disease. The purpose of this research is to investigate the significant expression of two variables, tristetraprolin (TTP) and miR-16, which are known to be regulators of BDNF expression. Fifty Iranian Azeri SCZ patients were enrolled, and fifty healthy volunteers were age- and gender-matched as controls. A quantitative polymerase chain reaction measured the expression levels of the TTP and miR-16 in the peripheral blood (PB) of SCZ patients and healthy people. TTP expression levels in patients were higher than in controls, regardless of gender or age (posterior beta = 1.532, adjusted P-value = 0.012). TTP and miR-16 expression levels were found to be significantly correlated in both SCZ patients and healthy controls (r = 0.701, P < 0.001 and r = 0.777, P < 0.001, respectively). Due to the increased expression of TTP in SCZ and the existence of a significant correlation between TTP and miR-16, which helps to act on target mRNAs with AU-rich elements, this mechanism can be considered an influencing factor in SCZ.https://doi.org/10.1186/s12888-022-04442-9SchizophreniaTTPmiR-16ExpressionBDNFAU-rich elements |
| spellingShingle | Mohammad Reza Asadi Jalal Gharesouran Hani Sabaie Marziyeh Sadat Moslehian Hossein Dehghani Shahram Arsang-Jang Mohammad Taheri Deniz Mortazavi Bashdar Mahmud Hussen Arezou Sayad Maryam Rezazadeh Assessing the expression of two post-transcriptional BDNF regulators, TTP and miR-16 in the peripheral blood of patients with Schizophrenia BMC Psychiatry Schizophrenia TTP miR-16 Expression BDNF AU-rich elements |
| title | Assessing the expression of two post-transcriptional BDNF regulators, TTP and miR-16 in the peripheral blood of patients with Schizophrenia |
| title_full | Assessing the expression of two post-transcriptional BDNF regulators, TTP and miR-16 in the peripheral blood of patients with Schizophrenia |
| title_fullStr | Assessing the expression of two post-transcriptional BDNF regulators, TTP and miR-16 in the peripheral blood of patients with Schizophrenia |
| title_full_unstemmed | Assessing the expression of two post-transcriptional BDNF regulators, TTP and miR-16 in the peripheral blood of patients with Schizophrenia |
| title_short | Assessing the expression of two post-transcriptional BDNF regulators, TTP and miR-16 in the peripheral blood of patients with Schizophrenia |
| title_sort | assessing the expression of two post transcriptional bdnf regulators ttp and mir 16 in the peripheral blood of patients with schizophrenia |
| topic | Schizophrenia TTP miR-16 Expression BDNF AU-rich elements |
| url | https://doi.org/10.1186/s12888-022-04442-9 |
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