EGFR-targeted bacteriophage lambda penetrates model stromal and colorectal carcinoma tissues, is taken up into carcinoma cells, and interferes with 3-dimensional tumor formation

EGFR-targeted bacteriophage lambda penetrates model stromal and colorectal carcinoma tissues, is taken up into carcinoma cells, and interferes with 3-dimensional tumor formation

IntroductionColorectal cancer and other adult solid cancers pose a significant challenge for successful treatment because the tumor microenvironment both hinders the action of conventional therapeutics and suppresses the immune activities of infiltrating leukocytes. The immune suppression is largely...

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Bibliographic Details
Main Authors: Haein Huh, Ding-Wen Chen, Marianna Foldvari, Roderick Slavcev, Jonathan Blay
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
phage therapy
epidermal growth factor receptors
colorectal cancer
spheroids
tumor microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.957233/full

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