Anti-tumor effects of low-dose metronomic vinorelbine in combination with alpelisib in breast cancer cells

Anti-tumor effects of low-dose metronomic vinorelbine in combination with alpelisib in breast cancer cells

In metastatic breast cancer (MBC), PIK3CA mutations, activating the phosphatidylinositol 3-kinase (PI3K) signaling pathway seem to be associated with chemotherapy resistance and poor outcome. Inhibition of the PI3K signaling pathway may lead to sensitization and prevention of the development of resi...

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Bibliographic Details
Main Authors: Slavomir Krajnak, Jannis Patrik Trier, Pauline Friederike Heinzmann, Katharina Anic, Anne-Sophie Heimes, Amelie Loewe, Marcus Schmidt, Marco Johannes Battista, Annette Hasenburg, Walburgis Brenner
Format: Article
Language:English
Published: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund 2023-01-01
Series:EXCLI Journal : Experimental and Clinical Sciences
Subjects:
low-dose metronomic chemotherapy
pik3ca mutation
vinorelbine
alpelisib
breast cancer
Online Access:https://www.excli.de/index.php/excli/article/view/5064

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