Salivary Metabolomics for Diagnosis and Monitoring Diseases: Challenges and Possibilities
Saliva is a useful biological fluid and a valuable source of biological information. Saliva contains many of the same components that can be found in blood or serum, but the components of interest tend to be at a lower concentration in saliva, and their analysis demands more sensitive techniques. Me...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/11/9/587 |
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| author | Eelis Hyvärinen Minttu Savolainen Jopi J. W. Mikkonen Arja M. Kullaa |
| author_facet | Eelis Hyvärinen Minttu Savolainen Jopi J. W. Mikkonen Arja M. Kullaa |
| author_sort | Eelis Hyvärinen |
| collection | DOAJ |
| description | Saliva is a useful biological fluid and a valuable source of biological information. Saliva contains many of the same components that can be found in blood or serum, but the components of interest tend to be at a lower concentration in saliva, and their analysis demands more sensitive techniques. Metabolomics is starting to emerge as a viable method for assessing the salivary metabolites which are generated by the biochemical processes in elucidating the pathways underlying different oral and systemic diseases. In oral diseases, salivary metabolomics has concentrated on periodontitis and oral cancer. Salivary metabolites of systemic diseases have been investigated mostly in the early diagnosis of different cancer, but also neurodegenerative diseases. This mini-review article aims to highlight the challenges and possibilities of salivary metabolomics from a clinical viewpoint. Furthermore, applications of the salivary metabolic profile in diagnosis and prognosis, monitoring the treatment success, and planning of personalized treatment of oral and systemic diseases are discussed. |
| first_indexed | 2024-03-10T07:27:35Z |
| format | Article |
| id | doaj.art-f53598ff15344e269ab68b0de805b572 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T07:27:35Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-f53598ff15344e269ab68b0de805b5722023-11-22T14:11:21ZengMDPI AGMetabolites2218-19892021-08-0111958710.3390/metabo11090587Salivary Metabolomics for Diagnosis and Monitoring Diseases: Challenges and PossibilitiesEelis Hyvärinen0Minttu Savolainen1Jopi J. W. Mikkonen2Arja M. Kullaa3Department of Oral Medicine, Institute of Dentistry, School of Medicine, Kuopio Campus, University of Eastern Finland, FI-70211 Kuopio, FinlandDepartment of Oral Medicine, Institute of Dentistry, School of Medicine, Kuopio Campus, University of Eastern Finland, FI-70211 Kuopio, FinlandDepartment of Oral Medicine, Institute of Dentistry, School of Medicine, Kuopio Campus, University of Eastern Finland, FI-70211 Kuopio, FinlandDepartment of Oral Medicine, Institute of Dentistry, School of Medicine, Kuopio Campus, University of Eastern Finland, FI-70211 Kuopio, FinlandSaliva is a useful biological fluid and a valuable source of biological information. Saliva contains many of the same components that can be found in blood or serum, but the components of interest tend to be at a lower concentration in saliva, and their analysis demands more sensitive techniques. Metabolomics is starting to emerge as a viable method for assessing the salivary metabolites which are generated by the biochemical processes in elucidating the pathways underlying different oral and systemic diseases. In oral diseases, salivary metabolomics has concentrated on periodontitis and oral cancer. Salivary metabolites of systemic diseases have been investigated mostly in the early diagnosis of different cancer, but also neurodegenerative diseases. This mini-review article aims to highlight the challenges and possibilities of salivary metabolomics from a clinical viewpoint. Furthermore, applications of the salivary metabolic profile in diagnosis and prognosis, monitoring the treatment success, and planning of personalized treatment of oral and systemic diseases are discussed.https://www.mdpi.com/2218-1989/11/9/587salivametabolomicsmass spectrometryNMR spectrometryoral diseasesystemic disease |
| spellingShingle | Eelis Hyvärinen Minttu Savolainen Jopi J. W. Mikkonen Arja M. Kullaa Salivary Metabolomics for Diagnosis and Monitoring Diseases: Challenges and Possibilities Metabolites saliva metabolomics mass spectrometry NMR spectrometry oral disease systemic disease |
| title | Salivary Metabolomics for Diagnosis and Monitoring Diseases: Challenges and Possibilities |
| title_full | Salivary Metabolomics for Diagnosis and Monitoring Diseases: Challenges and Possibilities |
| title_fullStr | Salivary Metabolomics for Diagnosis and Monitoring Diseases: Challenges and Possibilities |
| title_full_unstemmed | Salivary Metabolomics for Diagnosis and Monitoring Diseases: Challenges and Possibilities |
| title_short | Salivary Metabolomics for Diagnosis and Monitoring Diseases: Challenges and Possibilities |
| title_sort | salivary metabolomics for diagnosis and monitoring diseases challenges and possibilities |
| topic | saliva metabolomics mass spectrometry NMR spectrometry oral disease systemic disease |
| url | https://www.mdpi.com/2218-1989/11/9/587 |
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