Development of calcium alginate beads containing paclitaxel-loaded lipid-core nanocapsules intended for oral administration
We developed a solid formulation of calcium alginate beads containing paclitaxel-loaded lipid-core nanocapsules (PTX-LNC-Bead) intended for oral administration. The PTX-LNC liquid formulation was prepared by interfacial deposition and trapped into calcium alginate beads. These beads were characteriz...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universidade Federal do Rio Grande do Sul
2022-07-01
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| Series: | Drug Analytical Research |
| Online Access: | https://seer.ufrgs.br/index.php/dar/article/view/122299 |
| _version_ | 1827789374550441984 |
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| author | Taiane Medeiro Ciocheta Aline de Cristo Soares Alves Danieli Rosane Dallemole Rodrigo Cé Silvia Stanisçuaski Guterres Adriana Raffin Pohlmann |
| author_facet | Taiane Medeiro Ciocheta Aline de Cristo Soares Alves Danieli Rosane Dallemole Rodrigo Cé Silvia Stanisçuaski Guterres Adriana Raffin Pohlmann |
| author_sort | Taiane Medeiro Ciocheta |
| collection | DOAJ |
| description | We developed a solid formulation of calcium alginate beads containing paclitaxel-loaded lipid-core nanocapsules (PTX-LNC-Bead) intended for oral administration. The PTX-LNC liquid formulation was prepared by interfacial deposition and trapped into calcium alginate beads. These beads were characterized in terms of size, morphology, swelling rate, encapsulation efficiency, and release of PTX and LNC in simulated gastrointestinal fluids. Results showed that the beads were gastro-resistant with low swelling rate and drug release lower than 3.5% at pH 1.2 (2h). At pH 6.8, the beads showed high swelling rate and disintegration after 80 min. Drug release was 60% after 600 min. Particle sizing as a function of time confirmed that LNC were released intact from the beads at pH 6.8 showing that PTX-LNC-Bead is a promising product for PTX oral administration. Our results pave the way for novel formulations intended for drug targeting by the oral route.
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| first_indexed | 2024-03-11T17:19:10Z |
| format | Article |
| id | doaj.art-f535c701f7e9478f93321564cc4a1c0e |
| institution | Directory Open Access Journal |
| issn | 2527-2616 |
| language | English |
| last_indexed | 2024-03-11T17:19:10Z |
| publishDate | 2022-07-01 |
| publisher | Universidade Federal do Rio Grande do Sul |
| record_format | Article |
| series | Drug Analytical Research |
| spelling | doaj.art-f535c701f7e9478f93321564cc4a1c0e2023-10-19T18:12:14ZengUniversidade Federal do Rio Grande do SulDrug Analytical Research2527-26162022-07-016110.22456/2527-2616.122299Development of calcium alginate beads containing paclitaxel-loaded lipid-core nanocapsules intended for oral administrationTaiane Medeiro Ciocheta0Aline de Cristo Soares AlvesDanieli Rosane DallemoleRodrigo CéSilvia Stanisçuaski GuterresAdriana Raffin PohlmannUniversidade Federal do Rio Grande do SulWe developed a solid formulation of calcium alginate beads containing paclitaxel-loaded lipid-core nanocapsules (PTX-LNC-Bead) intended for oral administration. The PTX-LNC liquid formulation was prepared by interfacial deposition and trapped into calcium alginate beads. These beads were characterized in terms of size, morphology, swelling rate, encapsulation efficiency, and release of PTX and LNC in simulated gastrointestinal fluids. Results showed that the beads were gastro-resistant with low swelling rate and drug release lower than 3.5% at pH 1.2 (2h). At pH 6.8, the beads showed high swelling rate and disintegration after 80 min. Drug release was 60% after 600 min. Particle sizing as a function of time confirmed that LNC were released intact from the beads at pH 6.8 showing that PTX-LNC-Bead is a promising product for PTX oral administration. Our results pave the way for novel formulations intended for drug targeting by the oral route. https://seer.ufrgs.br/index.php/dar/article/view/122299 |
| spellingShingle | Taiane Medeiro Ciocheta Aline de Cristo Soares Alves Danieli Rosane Dallemole Rodrigo Cé Silvia Stanisçuaski Guterres Adriana Raffin Pohlmann Development of calcium alginate beads containing paclitaxel-loaded lipid-core nanocapsules intended for oral administration Drug Analytical Research |
| title | Development of calcium alginate beads containing paclitaxel-loaded lipid-core nanocapsules intended for oral administration |
| title_full | Development of calcium alginate beads containing paclitaxel-loaded lipid-core nanocapsules intended for oral administration |
| title_fullStr | Development of calcium alginate beads containing paclitaxel-loaded lipid-core nanocapsules intended for oral administration |
| title_full_unstemmed | Development of calcium alginate beads containing paclitaxel-loaded lipid-core nanocapsules intended for oral administration |
| title_short | Development of calcium alginate beads containing paclitaxel-loaded lipid-core nanocapsules intended for oral administration |
| title_sort | development of calcium alginate beads containing paclitaxel loaded lipid core nanocapsules intended for oral administration |
| url | https://seer.ufrgs.br/index.php/dar/article/view/122299 |
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