MSI2 promotes translation of multiple IRES-containing oncogenes and virus to induce self-renewal of tumor initiating stem-like cells

MSI2 promotes translation of multiple IRES-containing oncogenes and virus to induce self-renewal of tumor initiating stem-like cells

Abstract RNA-binding protein Musashi 2 (MSI2) is elevated in several cancers and is linked to poor prognosis. Here, we tested if MSI2 promotes MYC and viral mRNA translation to induce self-renewal via an internal ribosome entry sequence (IRES). We performed RIP-seq using anti-MSI2 antibody in tumor-...

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Bibliographic Details
Main Authors: Da-Wei Yeh, Xuyao Zhao, Hifzur R. Siddique, Mengmei Zheng, Hye Yeon Choi, Tatsuya Machida, Padmini Narayanan, Yi Kou, Vasu Punj, Stanley M. Tahara, Douglas E. Feldman, Lin Chen, Keigo Machida
Format: Article
Language:English
Published: Nature Publishing Group 2023-04-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01427-9

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