Preterm Infants’ Airway Microbiome: A Scoping Review of the Current Evidence
The aim of this scoping review was to investigate and synthesize existing evidence on the airway microbiome of preterm infants to outline the prognostic and therapeutic significance of these microbiomes within the preterm population and identify gaps in current knowledge, proposing avenues for futur...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/16/4/465 |
| _version_ | 1797297370770178048 |
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| author | Sofia Fatima Giuseppina Colombo Chiara Nava Francesca Castoldi Valentina Fabiano Fabio Meneghin Gianluca Lista Francesco Cavigioli |
| author_facet | Sofia Fatima Giuseppina Colombo Chiara Nava Francesca Castoldi Valentina Fabiano Fabio Meneghin Gianluca Lista Francesco Cavigioli |
| author_sort | Sofia Fatima Giuseppina Colombo |
| collection | DOAJ |
| description | The aim of this scoping review was to investigate and synthesize existing evidence on the airway microbiome of preterm infants to outline the prognostic and therapeutic significance of these microbiomes within the preterm population and identify gaps in current knowledge, proposing avenues for future research. We performed a scoping review of the literature following the Arskey and O’Malley framework. In accordance with our inclusion criteria and the intended purpose of this scoping review, we identified a total of 21 articles. The investigation of the airway microbiome in preterm infants has revealed new insights into its unique characteristics, highlighting distinct dynamics when compared to term infants. Perinatal factors, such as the mode of delivery, chorioamnionitis, the respiratory support, and antibiotic treatment, could impact the composition of the airway microbiome. The ‘gut–lung axis’, examining the link between the lung and gut microbiome as well as modifications in respiratory microbiome across different sites and over time, has also been explored. Furthermore, correlations between the airway microbiome and adverse outcomes, such as bronchopulmonary dysplasia (BPD), have been established. Additional research in neonatal care is essential to understand the early colonization of infants’ airways and explore methods for its optimization. The critical opportunity to shape long-term health through microbiome-mediated effects likely lies within the neonatal period. |
| first_indexed | 2024-03-07T22:19:27Z |
| format | Article |
| id | doaj.art-f5404cc5f45e4ea9aa874726f4bc3b99 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-07T22:19:27Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-f5404cc5f45e4ea9aa874726f4bc3b992024-02-23T15:29:43ZengMDPI AGNutrients2072-66432024-02-0116446510.3390/nu16040465Preterm Infants’ Airway Microbiome: A Scoping Review of the Current EvidenceSofia Fatima Giuseppina Colombo0Chiara Nava1Francesca Castoldi2Valentina Fabiano3Fabio Meneghin4Gianluca Lista5Francesco Cavigioli6Department of Pediatrics, Buzzi Children’s Hospital, 20154 Milan, ItalyDepartment of Pediatrics, Buzzi Children’s Hospital, 20154 Milan, ItalyDivision of Neonatology, Buzzi Children’s Hospital, 20154 Milan, ItalyDepartment of Pediatrics, Buzzi Children’s Hospital, 20154 Milan, ItalyDivision of Neonatology, Buzzi Children’s Hospital, 20154 Milan, ItalyDivision of Neonatology, Buzzi Children’s Hospital, 20154 Milan, ItalyDivision of Neonatology, Buzzi Children’s Hospital, 20154 Milan, ItalyThe aim of this scoping review was to investigate and synthesize existing evidence on the airway microbiome of preterm infants to outline the prognostic and therapeutic significance of these microbiomes within the preterm population and identify gaps in current knowledge, proposing avenues for future research. We performed a scoping review of the literature following the Arskey and O’Malley framework. In accordance with our inclusion criteria and the intended purpose of this scoping review, we identified a total of 21 articles. The investigation of the airway microbiome in preterm infants has revealed new insights into its unique characteristics, highlighting distinct dynamics when compared to term infants. Perinatal factors, such as the mode of delivery, chorioamnionitis, the respiratory support, and antibiotic treatment, could impact the composition of the airway microbiome. The ‘gut–lung axis’, examining the link between the lung and gut microbiome as well as modifications in respiratory microbiome across different sites and over time, has also been explored. Furthermore, correlations between the airway microbiome and adverse outcomes, such as bronchopulmonary dysplasia (BPD), have been established. Additional research in neonatal care is essential to understand the early colonization of infants’ airways and explore methods for its optimization. The critical opportunity to shape long-term health through microbiome-mediated effects likely lies within the neonatal period.https://www.mdpi.com/2072-6643/16/4/465preterm infantslung microbiomeairway microbiome |
| spellingShingle | Sofia Fatima Giuseppina Colombo Chiara Nava Francesca Castoldi Valentina Fabiano Fabio Meneghin Gianluca Lista Francesco Cavigioli Preterm Infants’ Airway Microbiome: A Scoping Review of the Current Evidence Nutrients preterm infants lung microbiome airway microbiome |
| title | Preterm Infants’ Airway Microbiome: A Scoping Review of the Current Evidence |
| title_full | Preterm Infants’ Airway Microbiome: A Scoping Review of the Current Evidence |
| title_fullStr | Preterm Infants’ Airway Microbiome: A Scoping Review of the Current Evidence |
| title_full_unstemmed | Preterm Infants’ Airway Microbiome: A Scoping Review of the Current Evidence |
| title_short | Preterm Infants’ Airway Microbiome: A Scoping Review of the Current Evidence |
| title_sort | preterm infants airway microbiome a scoping review of the current evidence |
| topic | preterm infants lung microbiome airway microbiome |
| url | https://www.mdpi.com/2072-6643/16/4/465 |
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