Hallmarks of Severe COVID-19 Pathogenesis: A Pas de Deux Between Viral and Host Factors
Two years into Coronavirus Disease 2019 (COVID-19) pandemic, a comprehensive characterization of the pathogenesis of severe and critical forms of COVID-19 is still missing. While a deep dysregulation of both the magnitude and functionality of innate and adaptive immune responses have been described...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.912336/full |
| _version_ | 1811258267252293632 |
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| author | Roberta Rovito Matteo Augello Assaf Ben-Haim Valeria Bono Antonella d’Arminio Monforte Giulia Marchetti |
| author_facet | Roberta Rovito Matteo Augello Assaf Ben-Haim Valeria Bono Antonella d’Arminio Monforte Giulia Marchetti |
| author_sort | Roberta Rovito |
| collection | DOAJ |
| description | Two years into Coronavirus Disease 2019 (COVID-19) pandemic, a comprehensive characterization of the pathogenesis of severe and critical forms of COVID-19 is still missing. While a deep dysregulation of both the magnitude and functionality of innate and adaptive immune responses have been described in severe COVID-19, the mechanisms underlying such dysregulations are still a matter of scientific debate, in turn hampering the identification of new therapies and of subgroups of patients that would most benefit from individual clinical interventions. Here we review the current understanding of viral and host factors that contribute to immune dysregulation associated with COVID-19 severity in the attempt to unfold and broaden the comprehension of COVID-19 pathogenesis and to define correlates of protection to further inform strategies of targeted therapeutic interventions. |
| first_indexed | 2024-04-12T18:10:40Z |
| format | Article |
| id | doaj.art-f5418e1676524d21bde10aa60b825473 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T18:10:40Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f5418e1676524d21bde10aa60b8254732022-12-22T03:21:50ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-06-011310.3389/fimmu.2022.912336912336Hallmarks of Severe COVID-19 Pathogenesis: A Pas de Deux Between Viral and Host FactorsRoberta RovitoMatteo AugelloAssaf Ben-HaimValeria BonoAntonella d’Arminio MonforteGiulia MarchettiTwo years into Coronavirus Disease 2019 (COVID-19) pandemic, a comprehensive characterization of the pathogenesis of severe and critical forms of COVID-19 is still missing. While a deep dysregulation of both the magnitude and functionality of innate and adaptive immune responses have been described in severe COVID-19, the mechanisms underlying such dysregulations are still a matter of scientific debate, in turn hampering the identification of new therapies and of subgroups of patients that would most benefit from individual clinical interventions. Here we review the current understanding of viral and host factors that contribute to immune dysregulation associated with COVID-19 severity in the attempt to unfold and broaden the comprehension of COVID-19 pathogenesis and to define correlates of protection to further inform strategies of targeted therapeutic interventions.https://www.frontiersin.org/articles/10.3389/fimmu.2022.912336/fullSARS-CoV-2COVID-19severityimmune dysregulationbiomarkerimmunity |
| spellingShingle | Roberta Rovito Matteo Augello Assaf Ben-Haim Valeria Bono Antonella d’Arminio Monforte Giulia Marchetti Hallmarks of Severe COVID-19 Pathogenesis: A Pas de Deux Between Viral and Host Factors Frontiers in Immunology SARS-CoV-2 COVID-19 severity immune dysregulation biomarker immunity |
| title | Hallmarks of Severe COVID-19 Pathogenesis: A Pas de Deux Between Viral and Host Factors |
| title_full | Hallmarks of Severe COVID-19 Pathogenesis: A Pas de Deux Between Viral and Host Factors |
| title_fullStr | Hallmarks of Severe COVID-19 Pathogenesis: A Pas de Deux Between Viral and Host Factors |
| title_full_unstemmed | Hallmarks of Severe COVID-19 Pathogenesis: A Pas de Deux Between Viral and Host Factors |
| title_short | Hallmarks of Severe COVID-19 Pathogenesis: A Pas de Deux Between Viral and Host Factors |
| title_sort | hallmarks of severe covid 19 pathogenesis a pas de deux between viral and host factors |
| topic | SARS-CoV-2 COVID-19 severity immune dysregulation biomarker immunity |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.912336/full |
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