Left ventricular function assessment after aortic and renal intervention in Takayasu arteritis by speckle tracking echocardiography: A pilot study
Background: Overt left ventricular (LV) dysfunction and congestive heart failure are known entities in Takayasu arteritis (TA). Subclinical LV dysfunction may develop in these patients despite normal LV ejection fraction (LVEF). Moreover, effect of treatment of aortic or renal artery narrowing in su...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-03-01
|
| Series: | Indian Heart Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S001948322200030X |
| _version_ | 1828230517409972224 |
|---|---|
| author | Sudhir Mor Sanjay Tyagi Shekhar Kunal Ankit Bansal M.P. Girish Vishal Batra Mohit Dayal Gupta |
| author_facet | Sudhir Mor Sanjay Tyagi Shekhar Kunal Ankit Bansal M.P. Girish Vishal Batra Mohit Dayal Gupta |
| author_sort | Sudhir Mor |
| collection | DOAJ |
| description | Background: Overt left ventricular (LV) dysfunction and congestive heart failure are known entities in Takayasu arteritis (TA). Subclinical LV dysfunction may develop in these patients despite normal LV ejection fraction (LVEF). Moreover, effect of treatment of aortic or renal artery narrowing in such patients is unknown. Methods: This study included 15 angiographically confirmed TA patients undergoing aortic and/or renal intervention. A comprehensive clinical, biochemical and echocardiographic (2-dimensional, speckle tracking and tissue doppler imaging) evaluation were done at baseline, 72 h, and six months post intervention. Results: Six patients (40%) had reduced LVEF (<50%) at baseline while rest 9 (60%) patients had reduced global longitudinal strain (GLS) but normal EF. Diastolic filling pattern was abnormal in all the patients. In patients with baseline reduced EF, mean EF improved from 24.62 ± 12.14% to 45.6 ± 9.45% (p = 0.001), E/e’ ratio decreased from 15.15 ± 3.19 to 10.8 ± 2.56 (p = 0.005) and median NT pro BNP decreased from 1673 pg/ml (970–2401 pg/ml) to 80 pg/ml (40–354 pg/ml) (p = 0.001) at 6 months after interventional procedure. In patients with baseline normal EF, median NT pro BNP decreased from 512 pg/ml (80–898.5 pg/ml) to 34 pg/ml (29–70.8 pg/ml) (p < 0.01), mean GLS improved from −8.80 ± 0.77% to −16.3 ± 0.78% (p < 0.001) and mean E/e’ decreased from 12.93 ± 2.63 to 7.8 ± 2.73 (p = 0.005) at 6 months follow up. Conclusion: LV dysfunction is common in patients with TA and obstructive lesions in aorta or renal arteries. GLS can be used to assess subclinical systolic dysfunction in these patients. Timely intervention can improve LV dysfunction and can even reverse the subclinical changes. |
| first_indexed | 2024-04-12T18:49:39Z |
| format | Article |
| id | doaj.art-f5425a5cf1b648fabaa95077f9aac375 |
| institution | Directory Open Access Journal |
| issn | 0019-4832 |
| language | English |
| last_indexed | 2024-04-12T18:49:39Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Indian Heart Journal |
| spelling | doaj.art-f5425a5cf1b648fabaa95077f9aac3752022-12-22T03:20:31ZengElsevierIndian Heart Journal0019-48322022-03-01742139143Left ventricular function assessment after aortic and renal intervention in Takayasu arteritis by speckle tracking echocardiography: A pilot studySudhir Mor0Sanjay Tyagi1Shekhar Kunal2Ankit Bansal3M.P. Girish4Vishal Batra5Mohit Dayal Gupta6Department of Cardiology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, Delhi, IndiaDepartment of Cardiology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, Delhi, IndiaDepartment of Cardiology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, Delhi, IndiaDepartment of Cardiology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, Delhi, IndiaDepartment of Cardiology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, Delhi, IndiaDepartment of Cardiology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, Delhi, IndiaCorresponding author. Room no. 125, Academic block, Department of Cardiology, Govind Ballabh Pant Institute of Postgraduate Medical Education & Research, New Delhi, 110002, India.; Department of Cardiology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, Delhi, IndiaBackground: Overt left ventricular (LV) dysfunction and congestive heart failure are known entities in Takayasu arteritis (TA). Subclinical LV dysfunction may develop in these patients despite normal LV ejection fraction (LVEF). Moreover, effect of treatment of aortic or renal artery narrowing in such patients is unknown. Methods: This study included 15 angiographically confirmed TA patients undergoing aortic and/or renal intervention. A comprehensive clinical, biochemical and echocardiographic (2-dimensional, speckle tracking and tissue doppler imaging) evaluation were done at baseline, 72 h, and six months post intervention. Results: Six patients (40%) had reduced LVEF (<50%) at baseline while rest 9 (60%) patients had reduced global longitudinal strain (GLS) but normal EF. Diastolic filling pattern was abnormal in all the patients. In patients with baseline reduced EF, mean EF improved from 24.62 ± 12.14% to 45.6 ± 9.45% (p = 0.001), E/e’ ratio decreased from 15.15 ± 3.19 to 10.8 ± 2.56 (p = 0.005) and median NT pro BNP decreased from 1673 pg/ml (970–2401 pg/ml) to 80 pg/ml (40–354 pg/ml) (p = 0.001) at 6 months after interventional procedure. In patients with baseline normal EF, median NT pro BNP decreased from 512 pg/ml (80–898.5 pg/ml) to 34 pg/ml (29–70.8 pg/ml) (p < 0.01), mean GLS improved from −8.80 ± 0.77% to −16.3 ± 0.78% (p < 0.001) and mean E/e’ decreased from 12.93 ± 2.63 to 7.8 ± 2.73 (p = 0.005) at 6 months follow up. Conclusion: LV dysfunction is common in patients with TA and obstructive lesions in aorta or renal arteries. GLS can be used to assess subclinical systolic dysfunction in these patients. Timely intervention can improve LV dysfunction and can even reverse the subclinical changes.http://www.sciencedirect.com/science/article/pii/S001948322200030XEjection fractionGlobal longitudinal strainSpeckle tracking echocardiographySubclinical left ventricle dysfunctionTakayasu arteritis |
| spellingShingle | Sudhir Mor Sanjay Tyagi Shekhar Kunal Ankit Bansal M.P. Girish Vishal Batra Mohit Dayal Gupta Left ventricular function assessment after aortic and renal intervention in Takayasu arteritis by speckle tracking echocardiography: A pilot study Indian Heart Journal Ejection fraction Global longitudinal strain Speckle tracking echocardiography Subclinical left ventricle dysfunction Takayasu arteritis |
| title | Left ventricular function assessment after aortic and renal intervention in Takayasu arteritis by speckle tracking echocardiography: A pilot study |
| title_full | Left ventricular function assessment after aortic and renal intervention in Takayasu arteritis by speckle tracking echocardiography: A pilot study |
| title_fullStr | Left ventricular function assessment after aortic and renal intervention in Takayasu arteritis by speckle tracking echocardiography: A pilot study |
| title_full_unstemmed | Left ventricular function assessment after aortic and renal intervention in Takayasu arteritis by speckle tracking echocardiography: A pilot study |
| title_short | Left ventricular function assessment after aortic and renal intervention in Takayasu arteritis by speckle tracking echocardiography: A pilot study |
| title_sort | left ventricular function assessment after aortic and renal intervention in takayasu arteritis by speckle tracking echocardiography a pilot study |
| topic | Ejection fraction Global longitudinal strain Speckle tracking echocardiography Subclinical left ventricle dysfunction Takayasu arteritis |
| url | http://www.sciencedirect.com/science/article/pii/S001948322200030X |
| work_keys_str_mv | AT sudhirmor leftventricularfunctionassessmentafteraorticandrenalinterventionintakayasuarteritisbyspeckletrackingechocardiographyapilotstudy AT sanjaytyagi leftventricularfunctionassessmentafteraorticandrenalinterventionintakayasuarteritisbyspeckletrackingechocardiographyapilotstudy AT shekharkunal leftventricularfunctionassessmentafteraorticandrenalinterventionintakayasuarteritisbyspeckletrackingechocardiographyapilotstudy AT ankitbansal leftventricularfunctionassessmentafteraorticandrenalinterventionintakayasuarteritisbyspeckletrackingechocardiographyapilotstudy AT mpgirish leftventricularfunctionassessmentafteraorticandrenalinterventionintakayasuarteritisbyspeckletrackingechocardiographyapilotstudy AT vishalbatra leftventricularfunctionassessmentafteraorticandrenalinterventionintakayasuarteritisbyspeckletrackingechocardiographyapilotstudy AT mohitdayalgupta leftventricularfunctionassessmentafteraorticandrenalinterventionintakayasuarteritisbyspeckletrackingechocardiographyapilotstudy |