HMGB1 Increases IL-1β Production in Vascular Smooth Muscle Cells via NLRP3 Inflammasome

HMGB1 Increases IL-1β Production in Vascular Smooth Muscle Cells via NLRP3 Inflammasome

Vascular smooth muscle cells (VSMCs) are the major cell type in the blood vessel walls, and their phenotypic modulation is a key cellular event driving vascular remodeling. Although high mobility group box-1 (HMGB1) plays a pivotal role in inflammatory processes after vascular injuries, the importan...

Full description

Bibliographic Details
Main Authors: Eun Jung Kim, So Youn Park, Seung Eun Baek, Min A. Jang, Won Suk Lee, Sun Sik Bae, Koanhoi Kim, Chi Dae Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Physiology
Subjects:
HMGB1
IL-1β
NLRP3 inflammasome
VSMC
TLRs
RAGE
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2018.00313/full

Similar Items

Similar Items