Subcortical volume reduction and cortical thinning 3 months after switching to clozapine in treatment resistant schizophrenia

Subcortical volume reduction and cortical thinning 3 months after switching to clozapine in treatment resistant schizophrenia

Abstract The neurobiological effects of clozapine are under characterised. We examined the effects clozapine treatment on subcortical volume and cortical thickness and investigated whether macrostructural changes were linked to alterations in glutamate or N-acetylaspartate (NAA). Data were acquired...

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Bibliographic Details
Main Authors: Fanni Krajner, Laila Hadaya, Grant McQueen, Kyra-Verena Sendt, Amy Gillespie, Alessia Avila, John Lally, Emily P. Hedges, Kelly Diederen, Oliver D. Howes, Gareth J. Barker, David J. Lythgoe, Matthew J. Kempton, Philip McGuire, James H. MacCabe, Alice Egerton
Format: Article
Language:English
Published: Nature Portfolio 2022-03-01
Series:npj Schizophrenia
Online Access:https://doi.org/10.1038/s41537-022-00230-2

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