Preparation of a Sunitinib loaded microemulsion for ocular delivery and evaluation for the treatment of corneal neovascularization in vitro and in vivo

Preparation of a Sunitinib loaded microemulsion for ocular delivery and evaluation for the treatment of corneal neovascularization in vitro and in vivo

Background: Corneal neovascularization (CNV) is a pathological condition that can disrupt corneal transparency, thus harming visual acuity. However, there is no effective drug to treat CNV. Sunitinib (STB), a small-molecule multiple receptor tyrosine kinase inhibitor, was shown to have an effect on...

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Bibliographic Details
Main Authors: Jieran Shi, Jingjing Yang, Haohang Xu, Qing Luo, Jun Sun, Yali Zhang, Zhen Liang, Ningmin Zhao, Junjie Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Pharmacology
Subjects:
Sunitinib
microemulsion
ocular delivery
topical administration
corneal neovascularization
ocular pharmacokinetics
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1157084/full

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