NADPH Oxidase-derived ROS Induced by Chronic Intermittent Hypoxia Mediates Hypersensitivity of Lung Vagal C Fibers in Rats

NADPH Oxidase-derived ROS Induced by Chronic Intermittent Hypoxia Mediates Hypersensitivity of Lung Vagal C Fibers in Rats

Obstructive sleep apnea, manifested by exposure to chronic intermittent hypoxia (CIH) and excess production of reactive oxygen species (ROS) in the airways, is associated with hyperreactive airway diseases. ROS, particularly when created by NADPH oxidase, are known to sensitize lung vagal C fibers (...

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Bibliographic Details
Main Authors: Chang-Huan eYang, Wei-Ling eZhuang, Yan-Jhih eShen, Ching Jung eLai, Yu Ru eKou
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-05-01
Series:Frontiers in Physiology
Subjects:
NADPH Oxidase
reactive oxygen species;
chronic intermittent hypoxia;
airway hypersensitivity;
lung vagal C fibers;
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00166/full

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