Asymmetry Inside The Symmetry: Mechanisms and Disorders Of Laterality
Asymmetry of the left-right (L-R) axis is a feature of vertebrates that is apparent in the viscera and vasculature. An understanding of L-R patterning in human dev elopment is aided by familiarity with key events and important pathways in mammalian embryogenesis.The induction of L-R asymmetry follow...
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| Format: | Article |
| Language: | English |
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Medical Network
2006-04-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
| Subjects: | |
| Online Access: | http://gorm.com.tr/index.php/GORM/article/view/572 |
| _version_ | 1797920403117572096 |
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| author | Yasemin Alanay Ersin Gümüş Miray Sekkin Sebile Güler Nur Çakar |
| author_facet | Yasemin Alanay Ersin Gümüş Miray Sekkin Sebile Güler Nur Çakar |
| author_sort | Yasemin Alanay |
| collection | DOAJ |
| description | Asymmetry of the left-right (L-R) axis is a feature of vertebrates that is apparent in the viscera and vasculature. An understanding of L-R patterning in human dev elopment is aided by familiarity with key events and important pathways in mammalian embryogenesis.The induction of L-R asymmetry follows the establishment of the anteroposterior (A-P or rostrocaudal) and dorsov entral (D-V) axes and requires the pre-existing midline symmetry to be broken before sidedness is induced via a series of complex, coordinated molecular signaling events. In this review, our aim is to describe the molecular background of this embryological process, and give brief knowledge concerning its clinical consequences. |
| first_indexed | 2024-04-10T14:01:40Z |
| format | Article |
| id | doaj.art-f5452778d7174e239a0460516915859a |
| institution | Directory Open Access Journal |
| issn | 1300-4751 |
| language | English |
| last_indexed | 2024-04-10T14:01:40Z |
| publishDate | 2006-04-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj.art-f5452778d7174e239a0460516915859a2023-02-15T16:10:15ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512006-04-01121506Asymmetry Inside The Symmetry: Mechanisms and Disorders Of LateralityYasemin Alanay0Ersin Gümüş1Miray Sekkin2Sebile Güler3Nur Çakar4Clinical Genetics Unit, Department of Pediatrics, Hacettepe University Faculty of Medicine, AnkaraMedical Student, Hacettepe University Faculty of Medicine, AnkaraMedical Student, Hacettepe University Faculty of Medicine, AnkaraMedical Student, Hacettepe University Faculty of Medicine, AnkaraDepartment of Histology and Embryology, Hacettepe University Faculty of Medicine, AnkaraAsymmetry of the left-right (L-R) axis is a feature of vertebrates that is apparent in the viscera and vasculature. An understanding of L-R patterning in human dev elopment is aided by familiarity with key events and important pathways in mammalian embryogenesis.The induction of L-R asymmetry follows the establishment of the anteroposterior (A-P or rostrocaudal) and dorsov entral (D-V) axes and requires the pre-existing midline symmetry to be broken before sidedness is induced via a series of complex, coordinated molecular signaling events. In this review, our aim is to describe the molecular background of this embryological process, and give brief knowledge concerning its clinical consequences.http://gorm.com.tr/index.php/GORM/article/view/572Heterotaxy, Laterality, Situs anomalies |
| spellingShingle | Yasemin Alanay Ersin Gümüş Miray Sekkin Sebile Güler Nur Çakar Asymmetry Inside The Symmetry: Mechanisms and Disorders Of Laterality Gynecology Obstetrics & Reproductive Medicine Heterotaxy, Laterality, Situs anomalies |
| title | Asymmetry Inside The Symmetry: Mechanisms and Disorders Of Laterality |
| title_full | Asymmetry Inside The Symmetry: Mechanisms and Disorders Of Laterality |
| title_fullStr | Asymmetry Inside The Symmetry: Mechanisms and Disorders Of Laterality |
| title_full_unstemmed | Asymmetry Inside The Symmetry: Mechanisms and Disorders Of Laterality |
| title_short | Asymmetry Inside The Symmetry: Mechanisms and Disorders Of Laterality |
| title_sort | asymmetry inside the symmetry mechanisms and disorders of laterality |
| topic | Heterotaxy, Laterality, Situs anomalies |
| url | http://gorm.com.tr/index.php/GORM/article/view/572 |
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