Lysoquinone-TH1, a New Polyphenolic Tridecaketide Produced by Expressing the Lysolipin Minimal PKS II in Streptomyces albus

Lysoquinone-TH1, a New Polyphenolic Tridecaketide Produced by Expressing the Lysolipin Minimal PKS II in Streptomyces albus

The structural repertoire of bioactive naphthacene quinones is expanded by engineering Streptomyces albus to express the lysolipin minimal polyketide synthase II (PKS II) genes from Streptomyces tendae Tü 4042 (llpD-F) with the corresponding cyclase genes llpCI-CIII. Fermentation of the rec...

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Bibliographic Details
Main Authors: Torben Hofeditz, Claudia Eva-Maria Unsin, Jutta Wiese, Johannes F. Imhoff, Wolfgang Wohlleben, Stephanie Grond, Tilmann Weber
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Antibiotics
Subjects:
lysolipin
minimal PKS II
cyclases
benz[a]naphthacene quinone
tridecaketide
aromatic polyketide
pentacyclic angular polyphenol
extended polyketide chain
Online Access:http://www.mdpi.com/2079-6382/7/3/53

Internet

http://www.mdpi.com/2079-6382/7/3/53

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