Modelling the ecological dynamics of mosquito populations with multiple co-circulating Wolbachia strains
Abstract Wolbachia intracellular bacteria successfully reduce the transmissibility of arthropod-borne viruses (arboviruses) when introduced into virus-carrying vectors such as mosquitoes. Despite the progress made by introducing Wolbachia bacteria into the Aedes aegypti wild-type population to contr...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-12-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-25242-x |
| _version_ | 1811207954698862592 |
|---|---|
| author | Samson T. Ogunlade Adeshina I. Adekunle Emma S. McBryde Michael T. Meehan |
| author_facet | Samson T. Ogunlade Adeshina I. Adekunle Emma S. McBryde Michael T. Meehan |
| author_sort | Samson T. Ogunlade |
| collection | DOAJ |
| description | Abstract Wolbachia intracellular bacteria successfully reduce the transmissibility of arthropod-borne viruses (arboviruses) when introduced into virus-carrying vectors such as mosquitoes. Despite the progress made by introducing Wolbachia bacteria into the Aedes aegypti wild-type population to control arboviral infections, reports suggest that heat-induced loss-of-Wolbachia-infection as a result of climate change may reverse these gains. Novel, supplemental Wolbachia strains that are more resilient to increased temperatures may circumvent these concerns, and could potentially act synergistically with existing variants. In this article, we model the ecological dynamics among three distinct mosquito (sub)populations: a wild-type population free of any Wolbachia infection; an invading population infected with a particular Wolbachia strain; and a second invading population infected with a distinct Wolbachia strain from that of the first invader. We explore how the range of possible characteristics of each Wolbachia strain impacts mosquito prevalence. Further, we analyse the differential system governing the mosquito populations and the Wolbachia infection dynamics by computing the full set of basic and invasive reproduction numbers and use these to establish stability of identified equilibria. Our results show that releasing mosquitoes with two different strains of Wolbachia did not increase their prevalence, compared with a single-strain Wolbachia-infected mosquito introduction and only delayed Wolbachia dominance. |
| first_indexed | 2024-04-12T04:13:48Z |
| format | Article |
| id | doaj.art-f54acb98e55c42e3bc56f17ce5983c33 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T04:13:48Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-f54acb98e55c42e3bc56f17ce5983c332022-12-22T03:48:27ZengNature PortfolioScientific Reports2045-23222022-12-0112111410.1038/s41598-022-25242-xModelling the ecological dynamics of mosquito populations with multiple co-circulating Wolbachia strainsSamson T. Ogunlade0Adeshina I. Adekunle1Emma S. McBryde2Michael T. Meehan3Australian Institute of Tropical Health and Medicine, James Cook UniversityAustralian Institute of Tropical Health and Medicine, James Cook UniversityAustralian Institute of Tropical Health and Medicine, James Cook UniversityAustralian Institute of Tropical Health and Medicine, James Cook UniversityAbstract Wolbachia intracellular bacteria successfully reduce the transmissibility of arthropod-borne viruses (arboviruses) when introduced into virus-carrying vectors such as mosquitoes. Despite the progress made by introducing Wolbachia bacteria into the Aedes aegypti wild-type population to control arboviral infections, reports suggest that heat-induced loss-of-Wolbachia-infection as a result of climate change may reverse these gains. Novel, supplemental Wolbachia strains that are more resilient to increased temperatures may circumvent these concerns, and could potentially act synergistically with existing variants. In this article, we model the ecological dynamics among three distinct mosquito (sub)populations: a wild-type population free of any Wolbachia infection; an invading population infected with a particular Wolbachia strain; and a second invading population infected with a distinct Wolbachia strain from that of the first invader. We explore how the range of possible characteristics of each Wolbachia strain impacts mosquito prevalence. Further, we analyse the differential system governing the mosquito populations and the Wolbachia infection dynamics by computing the full set of basic and invasive reproduction numbers and use these to establish stability of identified equilibria. Our results show that releasing mosquitoes with two different strains of Wolbachia did not increase their prevalence, compared with a single-strain Wolbachia-infected mosquito introduction and only delayed Wolbachia dominance.https://doi.org/10.1038/s41598-022-25242-x |
| spellingShingle | Samson T. Ogunlade Adeshina I. Adekunle Emma S. McBryde Michael T. Meehan Modelling the ecological dynamics of mosquito populations with multiple co-circulating Wolbachia strains Scientific Reports |
| title | Modelling the ecological dynamics of mosquito populations with multiple co-circulating Wolbachia strains |
| title_full | Modelling the ecological dynamics of mosquito populations with multiple co-circulating Wolbachia strains |
| title_fullStr | Modelling the ecological dynamics of mosquito populations with multiple co-circulating Wolbachia strains |
| title_full_unstemmed | Modelling the ecological dynamics of mosquito populations with multiple co-circulating Wolbachia strains |
| title_short | Modelling the ecological dynamics of mosquito populations with multiple co-circulating Wolbachia strains |
| title_sort | modelling the ecological dynamics of mosquito populations with multiple co circulating wolbachia strains |
| url | https://doi.org/10.1038/s41598-022-25242-x |
| work_keys_str_mv | AT samsontogunlade modellingtheecologicaldynamicsofmosquitopopulationswithmultiplecocirculatingwolbachiastrains AT adeshinaiadekunle modellingtheecologicaldynamicsofmosquitopopulationswithmultiplecocirculatingwolbachiastrains AT emmasmcbryde modellingtheecologicaldynamicsofmosquitopopulationswithmultiplecocirculatingwolbachiastrains AT michaeltmeehan modellingtheecologicaldynamicsofmosquitopopulationswithmultiplecocirculatingwolbachiastrains |