Effect of Diet and Supplementation on Serum Vitamin C Concentration and Antioxidant Activity in Dialysis Patients
Loss of vitamin C, especially in conjunction with an inadequate supply, can lead to decreased plasma concentrations of vitamin C. This in turn can lead to overt or subclinical deficiency. The present study aimed to evaluate the effects of diet and supplementation on vitamin C concentrations and seru...
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MDPI AG
2022-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/1/78 |
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| author | Anna Bogacka Anna Sobczak-Czynsz Edyta Balejko Angelika Heberlej Kazimierz Ciechanowski |
| author_facet | Anna Bogacka Anna Sobczak-Czynsz Edyta Balejko Angelika Heberlej Kazimierz Ciechanowski |
| author_sort | Anna Bogacka |
| collection | DOAJ |
| description | Loss of vitamin C, especially in conjunction with an inadequate supply, can lead to decreased plasma concentrations of vitamin C. This in turn can lead to overt or subclinical deficiency. The present study aimed to evaluate the effects of diet and supplementation on vitamin C concentrations and serum antioxidant activity (FRAP) in hemodialysis (HD) patients. Sixty-eight HD patients participated in the study. In all of them, the diet was initially determined, and they were divided into five groups according to the diet and supplementation used. Group 1 received an unchanged diet, considered by them to be optimal; in group 2, the standard diet used in HD patients was introduced; in group 3, a standard diet enriched with natural antioxidants was employed; in group 4, a standard diet as in group 2 was used, but enriched with supplements (vitamin C, vitamin E, Se, and Zn). In contrast, group 5 consisted of HD patients with coexisting diabetes. Vitamin C serum levels were determined by high-performance liquid chromatography HPLC and antioxidant activity by The Ferric Reducing Ability of Plasma FRAP. The study shows that a well-chosen diet can slow the build-up of malnutrition and increase antioxidant activity as measured by the FRAP method in the blood of hemodialysis patients. Vitamin C supplementation can improve antioxidant status in hemodialysis patients. * The results presented in this paper complement our study, which assessed the effect of diet on the activity of erythrocyte antioxidant enzymes: Catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px), but also on the concentrations of non-enzymatic antioxidants (tocopherols, carotenoids, and vitamin C) in hemodialysis patients. In the study, plasma malondialdehyde (MDA) concentrations were assessed as an indicator of oxidative damage. |
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| language | English |
| last_indexed | 2024-03-09T12:04:14Z |
| publishDate | 2022-12-01 |
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| series | Nutrients |
| spelling | doaj.art-f54b0c1115f7424492e76b51b6d490772023-11-30T23:00:27ZengMDPI AGNutrients2072-66432022-12-011517810.3390/nu15010078Effect of Diet and Supplementation on Serum Vitamin C Concentration and Antioxidant Activity in Dialysis PatientsAnna Bogacka0Anna Sobczak-Czynsz1Edyta Balejko2Angelika Heberlej3Kazimierz Ciechanowski4Department of Commodity Quality Assessment Process Engineering and Human Nutrition, Faculty of Food Sciences and Fisheries, West Pomeranian University of Technology in Szczecin, 71459 Szczecin, PolandDepartment of Commodity Quality Assessment Process Engineering and Human Nutrition, Faculty of Food Sciences and Fisheries, West Pomeranian University of Technology in Szczecin, 71459 Szczecin, PolandDepartment of Commodity Quality Assessment Process Engineering and Human Nutrition, Faculty of Food Sciences and Fisheries, West Pomeranian University of Technology in Szczecin, 71459 Szczecin, PolandDepartment of Commodity Quality Assessment Process Engineering and Human Nutrition, Faculty of Food Sciences and Fisheries, West Pomeranian University of Technology in Szczecin, 71459 Szczecin, PolandClinical Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University in Szczecin, 70111 Szczecin, PolandLoss of vitamin C, especially in conjunction with an inadequate supply, can lead to decreased plasma concentrations of vitamin C. This in turn can lead to overt or subclinical deficiency. The present study aimed to evaluate the effects of diet and supplementation on vitamin C concentrations and serum antioxidant activity (FRAP) in hemodialysis (HD) patients. Sixty-eight HD patients participated in the study. In all of them, the diet was initially determined, and they were divided into five groups according to the diet and supplementation used. Group 1 received an unchanged diet, considered by them to be optimal; in group 2, the standard diet used in HD patients was introduced; in group 3, a standard diet enriched with natural antioxidants was employed; in group 4, a standard diet as in group 2 was used, but enriched with supplements (vitamin C, vitamin E, Se, and Zn). In contrast, group 5 consisted of HD patients with coexisting diabetes. Vitamin C serum levels were determined by high-performance liquid chromatography HPLC and antioxidant activity by The Ferric Reducing Ability of Plasma FRAP. The study shows that a well-chosen diet can slow the build-up of malnutrition and increase antioxidant activity as measured by the FRAP method in the blood of hemodialysis patients. Vitamin C supplementation can improve antioxidant status in hemodialysis patients. * The results presented in this paper complement our study, which assessed the effect of diet on the activity of erythrocyte antioxidant enzymes: Catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px), but also on the concentrations of non-enzymatic antioxidants (tocopherols, carotenoids, and vitamin C) in hemodialysis patients. In the study, plasma malondialdehyde (MDA) concentrations were assessed as an indicator of oxidative damage.https://www.mdpi.com/2072-6643/15/1/78chronic renal failurehemodialysisvitamin CFRAPsupplementation |
| spellingShingle | Anna Bogacka Anna Sobczak-Czynsz Edyta Balejko Angelika Heberlej Kazimierz Ciechanowski Effect of Diet and Supplementation on Serum Vitamin C Concentration and Antioxidant Activity in Dialysis Patients Nutrients chronic renal failure hemodialysis vitamin C FRAP supplementation |
| title | Effect of Diet and Supplementation on Serum Vitamin C Concentration and Antioxidant Activity in Dialysis Patients |
| title_full | Effect of Diet and Supplementation on Serum Vitamin C Concentration and Antioxidant Activity in Dialysis Patients |
| title_fullStr | Effect of Diet and Supplementation on Serum Vitamin C Concentration and Antioxidant Activity in Dialysis Patients |
| title_full_unstemmed | Effect of Diet and Supplementation on Serum Vitamin C Concentration and Antioxidant Activity in Dialysis Patients |
| title_short | Effect of Diet and Supplementation on Serum Vitamin C Concentration and Antioxidant Activity in Dialysis Patients |
| title_sort | effect of diet and supplementation on serum vitamin c concentration and antioxidant activity in dialysis patients |
| topic | chronic renal failure hemodialysis vitamin C FRAP supplementation |
| url | https://www.mdpi.com/2072-6643/15/1/78 |
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