Association of adiponectin gene expression with atrial fibrillation in a Pakistani populace
Abstract Adiponectin, an adipocytokine produced and secreted by adipose tissue, has anti-diabetic, anti-atherogenic, and anti-inflammatory properties. This case-control study was aimed to assess the expression and serum levels of adiponectin in subject suffereing from atrial fibrillation (AF). The s...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-46388-2 |
| _version_ | 1797377015122231296 |
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| author | Saira Rafaqat Saima Sharif Mona Majeed Shagufta Naz Muhammad Saqib Farkhanda Manzoor |
| author_facet | Saira Rafaqat Saima Sharif Mona Majeed Shagufta Naz Muhammad Saqib Farkhanda Manzoor |
| author_sort | Saira Rafaqat |
| collection | DOAJ |
| description | Abstract Adiponectin, an adipocytokine produced and secreted by adipose tissue, has anti-diabetic, anti-atherogenic, and anti-inflammatory properties. This case-control study was aimed to assess the expression and serum levels of adiponectin in subject suffereing from atrial fibrillation (AF). The study's subjects (n = 690) were enrolled from the Punjab Institute of Cardiology, Lahore and were grouped into control, AF without Metabolic syndrome (MetS), and AF with MetS groups. Along with the collection of demographic data, an analysis of adiponectin and biochemical parameters were performed. A highly significant difference in serum levels of adiponectin was observed among the control, AF without MetS, and AF with MetS groups (61.61 ± 45.30 ng/ml, 37.20 ± 19.46 ng/ml, 63.78 ± 61.69 ng/ml). The expression analysis of adiponectin was decreased (n-fold = ̴ 0.30) in AF without MetS group as compared to control group (n-fold = ~ 1.16) but increased in AF with MetS group (n-fold = ̴ 6.26). The correlation analysis revealed a highly significant positive relationship between the expression of the adiponectin gene with waist-to-hip ratio (WHR) in AF without MetS group. Whereas, serum adiponectin was negatively related to serum triglycerides (TG) in AF with MetS group. In multiple regression analysis using adiponectin expression as the dependent variable, WHR was a determinant in AF without MetS. Whereas, when serum adiponectin was used as the dependent variable, serum TG was the determinant in group AF with MetS. The present study implicates that decreased expression and serum levels of adiponectin were associated with the development of AF in which WHR and serum TG also contributed towards the onset of atrial fibrillation. |
| first_indexed | 2024-03-08T19:47:53Z |
| format | Article |
| id | doaj.art-f54c5df537f24854a89f1492856ee043 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-08T19:47:53Z |
| publishDate | 2023-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-f54c5df537f24854a89f1492856ee0432023-12-24T12:17:35ZengNature PortfolioScientific Reports2045-23222023-12-011311910.1038/s41598-023-46388-2Association of adiponectin gene expression with atrial fibrillation in a Pakistani populaceSaira Rafaqat0Saima Sharif1Mona Majeed2Shagufta Naz3Muhammad Saqib4Farkhanda Manzoor5Department of Zoology, Lahore College for Women UniversityDepartment of Zoology, Lahore College for Women UniversityEmergency Department, Punjab Institute of CardiologyDepartment of Zoology, Lahore College for Women UniversityDepartment of Medicine, Sir Ganga Ram HospitalDepartment of Zoology, Lahore College for Women UniversityAbstract Adiponectin, an adipocytokine produced and secreted by adipose tissue, has anti-diabetic, anti-atherogenic, and anti-inflammatory properties. This case-control study was aimed to assess the expression and serum levels of adiponectin in subject suffereing from atrial fibrillation (AF). The study's subjects (n = 690) were enrolled from the Punjab Institute of Cardiology, Lahore and were grouped into control, AF without Metabolic syndrome (MetS), and AF with MetS groups. Along with the collection of demographic data, an analysis of adiponectin and biochemical parameters were performed. A highly significant difference in serum levels of adiponectin was observed among the control, AF without MetS, and AF with MetS groups (61.61 ± 45.30 ng/ml, 37.20 ± 19.46 ng/ml, 63.78 ± 61.69 ng/ml). The expression analysis of adiponectin was decreased (n-fold = ̴ 0.30) in AF without MetS group as compared to control group (n-fold = ~ 1.16) but increased in AF with MetS group (n-fold = ̴ 6.26). The correlation analysis revealed a highly significant positive relationship between the expression of the adiponectin gene with waist-to-hip ratio (WHR) in AF without MetS group. Whereas, serum adiponectin was negatively related to serum triglycerides (TG) in AF with MetS group. In multiple regression analysis using adiponectin expression as the dependent variable, WHR was a determinant in AF without MetS. Whereas, when serum adiponectin was used as the dependent variable, serum TG was the determinant in group AF with MetS. The present study implicates that decreased expression and serum levels of adiponectin were associated with the development of AF in which WHR and serum TG also contributed towards the onset of atrial fibrillation.https://doi.org/10.1038/s41598-023-46388-2 |
| spellingShingle | Saira Rafaqat Saima Sharif Mona Majeed Shagufta Naz Muhammad Saqib Farkhanda Manzoor Association of adiponectin gene expression with atrial fibrillation in a Pakistani populace Scientific Reports |
| title | Association of adiponectin gene expression with atrial fibrillation in a Pakistani populace |
| title_full | Association of adiponectin gene expression with atrial fibrillation in a Pakistani populace |
| title_fullStr | Association of adiponectin gene expression with atrial fibrillation in a Pakistani populace |
| title_full_unstemmed | Association of adiponectin gene expression with atrial fibrillation in a Pakistani populace |
| title_short | Association of adiponectin gene expression with atrial fibrillation in a Pakistani populace |
| title_sort | association of adiponectin gene expression with atrial fibrillation in a pakistani populace |
| url | https://doi.org/10.1038/s41598-023-46388-2 |
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