Sterols, Oxysterols, and Accessible Cholesterol: Signalling for Homeostasis, in Immunity and During Development
In this article we discuss the concept of accessible plasma membrane cholesterol and its involvement as a signalling molecule. Changes in plasma membrane accessible cholesterol, although only being minor in the context of total cholesterol plasma membrane cholesterol and total cell cholesterol, are...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2021.723224/full |
| _version_ | 1818730516324548608 |
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| author | William J. Griffiths Yuqin Wang |
| author_facet | William J. Griffiths Yuqin Wang |
| author_sort | William J. Griffiths |
| collection | DOAJ |
| description | In this article we discuss the concept of accessible plasma membrane cholesterol and its involvement as a signalling molecule. Changes in plasma membrane accessible cholesterol, although only being minor in the context of total cholesterol plasma membrane cholesterol and total cell cholesterol, are a key regulator of overall cellular cholesterol homeostasis by the SREBP pathway. Accessible cholesterol also provides the second messenger between patched 1 and smoothened in the hedgehog signalling pathway important during development, and its depletion may provide a mechanism of resistance to microbial pathogens including SARS-CoV-2. We revise the hypothesis that oxysterols are a signalling form of cholesterol, in this instance as a rapidly acting and paracrine version of accessible cholesterol. |
| first_indexed | 2024-12-17T23:03:01Z |
| format | Article |
| id | doaj.art-f54d4d6f6ac147e78323d1aceabdcea9 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-17T23:03:01Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-f54d4d6f6ac147e78323d1aceabdcea92022-12-21T21:29:21ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-10-011210.3389/fphys.2021.723224723224Sterols, Oxysterols, and Accessible Cholesterol: Signalling for Homeostasis, in Immunity and During DevelopmentWilliam J. GriffithsYuqin WangIn this article we discuss the concept of accessible plasma membrane cholesterol and its involvement as a signalling molecule. Changes in plasma membrane accessible cholesterol, although only being minor in the context of total cholesterol plasma membrane cholesterol and total cell cholesterol, are a key regulator of overall cellular cholesterol homeostasis by the SREBP pathway. Accessible cholesterol also provides the second messenger between patched 1 and smoothened in the hedgehog signalling pathway important during development, and its depletion may provide a mechanism of resistance to microbial pathogens including SARS-CoV-2. We revise the hypothesis that oxysterols are a signalling form of cholesterol, in this instance as a rapidly acting and paracrine version of accessible cholesterol.https://www.frontiersin.org/articles/10.3389/fphys.2021.723224/full25-hydroxycholesterolSREBP pathwayINSIGHMG-CoA reductaseSARS-CoV-2hedgehog signalling pathway |
| spellingShingle | William J. Griffiths Yuqin Wang Sterols, Oxysterols, and Accessible Cholesterol: Signalling for Homeostasis, in Immunity and During Development Frontiers in Physiology 25-hydroxycholesterol SREBP pathway INSIG HMG-CoA reductase SARS-CoV-2 hedgehog signalling pathway |
| title | Sterols, Oxysterols, and Accessible Cholesterol: Signalling for Homeostasis, in Immunity and During Development |
| title_full | Sterols, Oxysterols, and Accessible Cholesterol: Signalling for Homeostasis, in Immunity and During Development |
| title_fullStr | Sterols, Oxysterols, and Accessible Cholesterol: Signalling for Homeostasis, in Immunity and During Development |
| title_full_unstemmed | Sterols, Oxysterols, and Accessible Cholesterol: Signalling for Homeostasis, in Immunity and During Development |
| title_short | Sterols, Oxysterols, and Accessible Cholesterol: Signalling for Homeostasis, in Immunity and During Development |
| title_sort | sterols oxysterols and accessible cholesterol signalling for homeostasis in immunity and during development |
| topic | 25-hydroxycholesterol SREBP pathway INSIG HMG-CoA reductase SARS-CoV-2 hedgehog signalling pathway |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2021.723224/full |
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