Active C4 Electrodes for Local Field Potential Recording Applications
Extracellular neural recording, with multi-electrode arrays (MEAs), is a powerful method used to study neural function at the network level. However, in a high density array, it can be costly and time consuming to integrate the active circuit with the expensive electrodes. In this paper, we present...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-02-01
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| Series: | Sensors |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1424-8220/16/2/198 |
| _version_ | 1798002463964397568 |
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| author | Lu Wang David Freedman Mesut Sahin M. Selim Ünlü Ronald Knepper |
| author_facet | Lu Wang David Freedman Mesut Sahin M. Selim Ünlü Ronald Knepper |
| author_sort | Lu Wang |
| collection | DOAJ |
| description | Extracellular neural recording, with multi-electrode arrays (MEAs), is a powerful method used to study neural function at the network level. However, in a high density array, it can be costly and time consuming to integrate the active circuit with the expensive electrodes. In this paper, we present a 4 mm × 4 mm neural recording integrated circuit (IC) chip, utilizing IBM C4 bumps as recording electrodes, which enable a seamless active chip and electrode integration. The IC chip was designed and fabricated in a 0.13 μm BiCMOS process for both in vitro and in vivo applications. It has an input-referred noise of 4.6 μV rms for the bandwidth of 10 Hz to 10 kHz and a power dissipation of 11.25 mW at 2.5 V, or 43.9 μW per input channel. This prototype is scalable for implementing larger number and higher density electrode arrays. To validate the functionality of the chip, electrical testing results and acute in vivo recordings from a rat barrel cortex are presented. |
| first_indexed | 2024-04-11T11:52:35Z |
| format | Article |
| id | doaj.art-f54d908d6b1a4b71abdc1106f07d53df |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-11T11:52:35Z |
| publishDate | 2016-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-f54d908d6b1a4b71abdc1106f07d53df2022-12-22T04:25:16ZengMDPI AGSensors1424-82202016-02-0116219810.3390/s16020198s16020198Active C4 Electrodes for Local Field Potential Recording ApplicationsLu Wang0David Freedman1Mesut Sahin2M. Selim Ünlü3Ronald Knepper4Department of Electrical and Computer Engineering, Boston University, 8 Saint Mary’s St, Boston 02215, MA, USADepartment of Electrical and Computer Engineering, Boston University, 8 Saint Mary’s St, Boston 02215, MA, USADepartment of Biomedical Engineering, New Jersey Institute of Technology, 323 Martin Luther King, Jr. Boulevard, University Heights Newark, Newark 07102, NJ, USADepartment of Electrical and Computer Engineering, Boston University, 8 Saint Mary’s St, Boston 02215, MA, USADepartment of Electrical and Computer Engineering, Boston University, 8 Saint Mary’s St, Boston 02215, MA, USAExtracellular neural recording, with multi-electrode arrays (MEAs), is a powerful method used to study neural function at the network level. However, in a high density array, it can be costly and time consuming to integrate the active circuit with the expensive electrodes. In this paper, we present a 4 mm × 4 mm neural recording integrated circuit (IC) chip, utilizing IBM C4 bumps as recording electrodes, which enable a seamless active chip and electrode integration. The IC chip was designed and fabricated in a 0.13 μm BiCMOS process for both in vitro and in vivo applications. It has an input-referred noise of 4.6 μV rms for the bandwidth of 10 Hz to 10 kHz and a power dissipation of 11.25 mW at 2.5 V, or 43.9 μW per input channel. This prototype is scalable for implementing larger number and higher density electrode arrays. To validate the functionality of the chip, electrical testing results and acute in vivo recordings from a rat barrel cortex are presented.http://www.mdpi.com/1424-8220/16/2/1983D electrodesC4CMOSextracellularin vitroin vivoMEAneural sensors |
| spellingShingle | Lu Wang David Freedman Mesut Sahin M. Selim Ünlü Ronald Knepper Active C4 Electrodes for Local Field Potential Recording Applications Sensors 3D electrodes C4 CMOS extracellular in vitro in vivo MEA neural sensors |
| title | Active C4 Electrodes for Local Field Potential Recording Applications |
| title_full | Active C4 Electrodes for Local Field Potential Recording Applications |
| title_fullStr | Active C4 Electrodes for Local Field Potential Recording Applications |
| title_full_unstemmed | Active C4 Electrodes for Local Field Potential Recording Applications |
| title_short | Active C4 Electrodes for Local Field Potential Recording Applications |
| title_sort | active c4 electrodes for local field potential recording applications |
| topic | 3D electrodes C4 CMOS extracellular in vitro in vivo MEA neural sensors |
| url | http://www.mdpi.com/1424-8220/16/2/198 |
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