Risk factors and glycation end products in patients with different forms of coronary heart disease and type 2 diabetes mellitus
Aim. To determine the levels of growth factors and glycation end products in patients with different forms of coronary heart disease (CHD) and type 2 diabetes mellitus (T2DM). Subjects and methods. A total of 134 patients with CHD and T2DM, including 38 patients with non-ST-elevation acute coronary...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2015-10-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/31809 |
| _version_ | 1811196672528613376 |
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| author | E V Ivannikova V Yu Kalashnikov O M Smirnova I V Kononenko A B Kuznetsov S A Terekhin |
| author_facet | E V Ivannikova V Yu Kalashnikov O M Smirnova I V Kononenko A B Kuznetsov S A Terekhin |
| author_sort | E V Ivannikova |
| collection | DOAJ |
| description | Aim. To determine the levels of growth factors and glycation end products in patients with different forms of coronary heart disease (CHD) and type 2 diabetes mellitus (T2DM). Subjects and methods. A total of 134 patients with CHD and T2DM, including 38 patients with non-ST-elevation acute coronary syndrome (ACS), were examined. The arterial and venous serum levels of basic fibroblast growth factor-β (FGF-β), transforming growth factor-β (TGF-β), placental growth factor (PlGF), advanced glycation end products (AGEs) and their receptors (RAGE) were estimated in all the patients. Results. A direct correlation was found between the degree of arterial stenosis and the level of growth factors and AGEs in the patients with T2DM; there was also a direct correlation of the examined factors with lipid metabolic parameters. There was a significant two-fold increase in FGF-β, PlGF, and RAGE levels in the patients with ACS. Conclusion. Hyperglycemia was found to negatively affect the progression of atherosclerotic changes in the vessel wall and on that of fibrotic processes. |
| first_indexed | 2024-04-12T01:01:47Z |
| format | Article |
| id | doaj.art-f5513ace006a46b79b848d9a4c069dd1 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-04-12T01:01:47Z |
| publishDate | 2015-10-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-f5513ace006a46b79b848d9a4c069dd12022-12-22T03:54:25Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422015-10-018710192528825Risk factors and glycation end products in patients with different forms of coronary heart disease and type 2 diabetes mellitusE V IvannikovaV Yu KalashnikovO M SmirnovaI V KononenkoA B KuznetsovS A TerekhinAim. To determine the levels of growth factors and glycation end products in patients with different forms of coronary heart disease (CHD) and type 2 diabetes mellitus (T2DM). Subjects and methods. A total of 134 patients with CHD and T2DM, including 38 patients with non-ST-elevation acute coronary syndrome (ACS), were examined. The arterial and venous serum levels of basic fibroblast growth factor-β (FGF-β), transforming growth factor-β (TGF-β), placental growth factor (PlGF), advanced glycation end products (AGEs) and their receptors (RAGE) were estimated in all the patients. Results. A direct correlation was found between the degree of arterial stenosis and the level of growth factors and AGEs in the patients with T2DM; there was also a direct correlation of the examined factors with lipid metabolic parameters. There was a significant two-fold increase in FGF-β, PlGF, and RAGE levels in the patients with ACS. Conclusion. Hyperglycemia was found to negatively affect the progression of atherosclerotic changes in the vessel wall and on that of fibrotic processes.https://ter-arkhiv.ru/0040-3660/article/view/31809fibroblast growth factorsintima-media complexglycation end productsdiabetes mellitusatherosclerosis |
| spellingShingle | E V Ivannikova V Yu Kalashnikov O M Smirnova I V Kononenko A B Kuznetsov S A Terekhin Risk factors and glycation end products in patients with different forms of coronary heart disease and type 2 diabetes mellitus Терапевтический архив fibroblast growth factors intima-media complex glycation end products diabetes mellitus atherosclerosis |
| title | Risk factors and glycation end products in patients with different forms of coronary heart disease and type 2 diabetes mellitus |
| title_full | Risk factors and glycation end products in patients with different forms of coronary heart disease and type 2 diabetes mellitus |
| title_fullStr | Risk factors and glycation end products in patients with different forms of coronary heart disease and type 2 diabetes mellitus |
| title_full_unstemmed | Risk factors and glycation end products in patients with different forms of coronary heart disease and type 2 diabetes mellitus |
| title_short | Risk factors and glycation end products in patients with different forms of coronary heart disease and type 2 diabetes mellitus |
| title_sort | risk factors and glycation end products in patients with different forms of coronary heart disease and type 2 diabetes mellitus |
| topic | fibroblast growth factors intima-media complex glycation end products diabetes mellitus atherosclerosis |
| url | https://ter-arkhiv.ru/0040-3660/article/view/31809 |
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