Delayed treatment-free response after romiplostim discontinuation in pediatric chronic immune thrombocytopenia
We report the case of a 16-month-old patient with chronic immune thrombocytopenia (ITP) patient who experienced delayed treatment-free response (TFR) after romiplostim treatment. He received intravenous immunoglobulin every month to maintain a platelet count above 20,000/μL for 2 years. Thereafter,...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Yeungnam University College of Medicine
2021-04-01
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| Series: | Yeungnam University Journal of Medicine |
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| Online Access: | http://www.e-yujm.org/upload/pdf/yujm-2020-00493.pdf |
| _version_ | 1818353363892305920 |
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| author | Hyun Ji Lim Young Tae Lim Jeong Ok Hah Jae Min Lee |
| author_facet | Hyun Ji Lim Young Tae Lim Jeong Ok Hah Jae Min Lee |
| author_sort | Hyun Ji Lim |
| collection | DOAJ |
| description | We report the case of a 16-month-old patient with chronic immune thrombocytopenia (ITP) patient who experienced delayed treatment-free response (TFR) after romiplostim treatment. He received intravenous immunoglobulin every month to maintain a platelet count above 20,000/μL for 2 years. Thereafter, he received rituximab and cyclosporine as second-line therapy, with no response, followed by romiplostim. After 4 weeks of treatment, the platelet count was maintained above 50,000/μL. Following 7 months of treatment, he discontinued romiplostim, and the platelet count decreased. His platelet counts remained above 50,000/μL, without any bleeding symptoms, 2 years after romiplostim discontinuation. This is the first report of TFR after romiplostim treatment in pediatric chronic ITP. |
| first_indexed | 2024-12-13T19:08:21Z |
| format | Article |
| id | doaj.art-f5535965e83e439495775d46f2804e98 |
| institution | Directory Open Access Journal |
| issn | 2384-0293 |
| language | English |
| last_indexed | 2024-12-13T19:08:21Z |
| publishDate | 2021-04-01 |
| publisher | Yeungnam University College of Medicine |
| record_format | Article |
| series | Yeungnam University Journal of Medicine |
| spelling | doaj.art-f5535965e83e439495775d46f2804e982022-12-21T23:34:29ZengYeungnam University College of MedicineYeungnam University Journal of Medicine2384-02932021-04-0138216516810.12701/yujm.2020.004932603Delayed treatment-free response after romiplostim discontinuation in pediatric chronic immune thrombocytopeniaHyun Ji Lim0Young Tae Lim1Jeong Ok Hah2Jae Min Lee3 Department of Pediatrics, Yeungnam University Hospital, Daegu, Korea Department of Pediatrics, Yeungnam University Hospital, Daegu, Korea Department of Pediatrics, Daegu Fatima Hospital, Daegu, Korea Department of Pediatrics, Yeungnam University College of Medicine, Daegu, KoreaWe report the case of a 16-month-old patient with chronic immune thrombocytopenia (ITP) patient who experienced delayed treatment-free response (TFR) after romiplostim treatment. He received intravenous immunoglobulin every month to maintain a platelet count above 20,000/μL for 2 years. Thereafter, he received rituximab and cyclosporine as second-line therapy, with no response, followed by romiplostim. After 4 weeks of treatment, the platelet count was maintained above 50,000/μL. Following 7 months of treatment, he discontinued romiplostim, and the platelet count decreased. His platelet counts remained above 50,000/μL, without any bleeding symptoms, 2 years after romiplostim discontinuation. This is the first report of TFR after romiplostim treatment in pediatric chronic ITP.http://www.e-yujm.org/upload/pdf/yujm-2020-00493.pdfchildimmune thrombocytopeniaidiopathic thrombocytopenic purpuraromiplostimtreatment-free response |
| spellingShingle | Hyun Ji Lim Young Tae Lim Jeong Ok Hah Jae Min Lee Delayed treatment-free response after romiplostim discontinuation in pediatric chronic immune thrombocytopenia Yeungnam University Journal of Medicine child immune thrombocytopenia idiopathic thrombocytopenic purpura romiplostim treatment-free response |
| title | Delayed treatment-free response after romiplostim discontinuation in pediatric chronic immune thrombocytopenia |
| title_full | Delayed treatment-free response after romiplostim discontinuation in pediatric chronic immune thrombocytopenia |
| title_fullStr | Delayed treatment-free response after romiplostim discontinuation in pediatric chronic immune thrombocytopenia |
| title_full_unstemmed | Delayed treatment-free response after romiplostim discontinuation in pediatric chronic immune thrombocytopenia |
| title_short | Delayed treatment-free response after romiplostim discontinuation in pediatric chronic immune thrombocytopenia |
| title_sort | delayed treatment free response after romiplostim discontinuation in pediatric chronic immune thrombocytopenia |
| topic | child immune thrombocytopenia idiopathic thrombocytopenic purpura romiplostim treatment-free response |
| url | http://www.e-yujm.org/upload/pdf/yujm-2020-00493.pdf |
| work_keys_str_mv | AT hyunjilim delayedtreatmentfreeresponseafterromiplostimdiscontinuationinpediatricchronicimmunethrombocytopenia AT youngtaelim delayedtreatmentfreeresponseafterromiplostimdiscontinuationinpediatricchronicimmunethrombocytopenia AT jeongokhah delayedtreatmentfreeresponseafterromiplostimdiscontinuationinpediatricchronicimmunethrombocytopenia AT jaeminlee delayedtreatmentfreeresponseafterromiplostimdiscontinuationinpediatricchronicimmunethrombocytopenia |