Highly Variable Pharmacokinetics of Tyramine in Humans and Polymorphisms in OCT1, CYP2D6, and MAO-A

Highly Variable Pharmacokinetics of Tyramine in Humans and Polymorphisms in OCT1, CYP2D6, and MAO-A

Tyramine, formed by the decarboxylation of tyrosine, is a natural constituent of numerous food products. As an indirect sympathomimetic, it can have potentially dangerous hypertensive effects. In vitro data indicated that the pharmacokinetics of tyramine possibly depend on the organic cation transpo...

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Bibliographic Details
Main Authors: Muhammad Rafehi, Frank Faltraco, Johannes Matthaei, Thomas Prukop, Ole Jensen, Aileen Grytzmann, Felix G. Blome, Ralf Günter Berger, Ulrich Krings, Stefan V. Vormfelde, Mladen V. Tzvetkov, Jürgen Brockmöller
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Pharmacology
Subjects:
biogenic amine
CYP2D6
MAO
monoamine oxidase
OCT1
pressor response
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01297/full

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