ROLE OF TOLL-LIKE RECEPTORS AND THEIR ENDOGENOUS LIGANDS IN THE PATHOGENESIS OF RHEUMATOID ARTHRITIS: A REVIEW OF LITERATURE
Despite great advances in the study of the pathogenesis of rheumatoid arthritis (RA), which could design a radically new class of fundamentally sound therapeutic agents, many immunological aspects remain fully unstudied. The role of innate immunity mechanisms in the development of autoimmune inflamm...
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2016-03-01
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| Series: | Научно-практическая ревматология |
| Subjects: | |
| Online Access: | https://rsp.mediar-press.net/rsp/article/view/2172 |
| _version_ | 1797862752067256320 |
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| author | M. Yu. Volkov |
| author_facet | M. Yu. Volkov |
| author_sort | M. Yu. Volkov |
| collection | DOAJ |
| description | Despite great advances in the study of the pathogenesis of rheumatoid arthritis (RA), which could design a radically new class of fundamentally sound therapeutic agents, many immunological aspects remain fully unstudied. The role of innate immunity mechanisms in the development of autoimmune inflammation is one of the important issues in the pathogenesis of not only RA, but also all rheumatic diseases. The discovery of pattern recognition receptors (PRRs) has allowed fundamental immunology to make a great stride toward understanding how these mechanisms are implemented. The study of membranous and endosomal Toll-like receptors (TLRs), the most extensive and well-studied group of PRRs, is a promising area of modern rheumatology. It is significant to note that some molecular agents, the presence of which in tissue is associated with its damage, are able to stimulate TLRs. They have received the name damage-associated molecular patterns (DAMPs). The paper provides a review of the literature on the mechanisms of TLR-mediated signaling pathways, on different aspects of a role of individual TLRs and DAMPs in the induction and maintenance of autoimmune inflammation in RA, and on prospects for targeted therapy aimed at inhibiting some TLRs and DAMPs. |
| first_indexed | 2024-04-09T22:24:41Z |
| format | Article |
| id | doaj.art-f5594422e2bc4704a5794f8e0849e302 |
| institution | Directory Open Access Journal |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| last_indexed | 2024-04-09T22:24:41Z |
| publishDate | 2016-03-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj.art-f5594422e2bc4704a5794f8e0849e3022023-03-22T13:45:51ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922016-03-01541788510.14412/1995-4484-2016-78-852051ROLE OF TOLL-LIKE RECEPTORS AND THEIR ENDOGENOUS LIGANDS IN THE PATHOGENESIS OF RHEUMATOID ARTHRITIS: A REVIEW OF LITERATUREM. Yu. Volkov0V.A. Nasonova Research Institute of RheumatologyDespite great advances in the study of the pathogenesis of rheumatoid arthritis (RA), which could design a radically new class of fundamentally sound therapeutic agents, many immunological aspects remain fully unstudied. The role of innate immunity mechanisms in the development of autoimmune inflammation is one of the important issues in the pathogenesis of not only RA, but also all rheumatic diseases. The discovery of pattern recognition receptors (PRRs) has allowed fundamental immunology to make a great stride toward understanding how these mechanisms are implemented. The study of membranous and endosomal Toll-like receptors (TLRs), the most extensive and well-studied group of PRRs, is a promising area of modern rheumatology. It is significant to note that some molecular agents, the presence of which in tissue is associated with its damage, are able to stimulate TLRs. They have received the name damage-associated molecular patterns (DAMPs). The paper provides a review of the literature on the mechanisms of TLR-mediated signaling pathways, on different aspects of a role of individual TLRs and DAMPs in the induction and maintenance of autoimmune inflammation in RA, and on prospects for targeted therapy aimed at inhibiting some TLRs and DAMPs.https://rsp.mediar-press.net/rsp/article/view/2172rheumatoid arthritisinnate immunitypattern recognition receptorstoll-like receptorsdamage-associated molecular patternsautoimmune inflammation |
| spellingShingle | M. Yu. Volkov ROLE OF TOLL-LIKE RECEPTORS AND THEIR ENDOGENOUS LIGANDS IN THE PATHOGENESIS OF RHEUMATOID ARTHRITIS: A REVIEW OF LITERATURE Научно-практическая ревматология rheumatoid arthritis innate immunity pattern recognition receptors toll-like receptors damage-associated molecular patterns autoimmune inflammation |
| title | ROLE OF TOLL-LIKE RECEPTORS AND THEIR ENDOGENOUS LIGANDS IN THE PATHOGENESIS OF RHEUMATOID ARTHRITIS: A REVIEW OF LITERATURE |
| title_full | ROLE OF TOLL-LIKE RECEPTORS AND THEIR ENDOGENOUS LIGANDS IN THE PATHOGENESIS OF RHEUMATOID ARTHRITIS: A REVIEW OF LITERATURE |
| title_fullStr | ROLE OF TOLL-LIKE RECEPTORS AND THEIR ENDOGENOUS LIGANDS IN THE PATHOGENESIS OF RHEUMATOID ARTHRITIS: A REVIEW OF LITERATURE |
| title_full_unstemmed | ROLE OF TOLL-LIKE RECEPTORS AND THEIR ENDOGENOUS LIGANDS IN THE PATHOGENESIS OF RHEUMATOID ARTHRITIS: A REVIEW OF LITERATURE |
| title_short | ROLE OF TOLL-LIKE RECEPTORS AND THEIR ENDOGENOUS LIGANDS IN THE PATHOGENESIS OF RHEUMATOID ARTHRITIS: A REVIEW OF LITERATURE |
| title_sort | role of toll like receptors and their endogenous ligands in the pathogenesis of rheumatoid arthritis a review of literature |
| topic | rheumatoid arthritis innate immunity pattern recognition receptors toll-like receptors damage-associated molecular patterns autoimmune inflammation |
| url | https://rsp.mediar-press.net/rsp/article/view/2172 |
| work_keys_str_mv | AT myuvolkov roleoftolllikereceptorsandtheirendogenousligandsinthepathogenesisofrheumatoidarthritisareviewofliterature |